BRD-U25771771_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-U25771771_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
AQP3 aquaporin 3 (Gill blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
DEPTOR DEP domain containing MTOR-interacting protein
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FN1 fibronectin 1
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GUSBP3 glucuronidase, beta pseudogene 3
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
IER3 immediate early response 3
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LRRC16A leucine rich repeat containing 16A
LTA4H leukotriene A4 hydrolase
MAOA monoamine oxidase A
MSN moesin
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNMA2 paraneoplastic Ma antigen 2
PNRC1 proline-rich nuclear receptor coactivator 1
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK1 salt-inducible kinase 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TSC22D1 TSC22 domain family, member 1
VAMP8 vesicle-associated membrane protein 8
VIM vimentin
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ASRGL1 asparaginase like 1
C2CD2 C2 calcium-dependent domain containing 2
CCDC86 coiled-coil domain containing 86
CCND3 cyclin D3
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL4A5 collagen, type IV, alpha 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS2L1 growth arrest-specific 2 like 1
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
HIC2 hypermethylated in cancer 2
HSPH1 heat shock 105kDa/110kDa protein 1
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KIAA0232 KIAA0232
KPNA3 karyopherin alpha 3 (importin alpha 4)
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NOP16 NOP16 nucleolar protein
NT5DC2 5'-nucleotidase domain containing 2
NUP98 nucleoporin 98kDa
PAK1IP1 PAK1 interacting protein 1
PCDH9 protocadherin 9
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
SLBP stem-loop binding protein
SMTN smoothelin
TATDN2 TatD DNase domain containing 2
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TFAM transcription factor A, mitochondrial
UGDH UDP-glucose 6-dehydrogenase
WDR1 WD repeat domain 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZWINT ZW10 interacting kinetochore protein
Funding