BRD-U29336476_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-U29336476_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACLY ATP citrate lyase
ADD3 adducin 3 (gamma)
ASPN asporin
BSG basigin (Ok blood group)
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CECR1 cat eye syndrome chromosome region, candidate 1
CLC Charcot-Leyden crystal galectin
CLCA2 chloride channel accessory 2
CNTNAP2 contactin associated protein-like 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTSK cathepsin K
CYCS cytochrome c, somatic
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DEFB1 defensin, beta 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EBP emopamil binding protein (sterol isomerase)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM117A family with sequence similarity 117, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G6PD glucose-6-phosphate dehydrogenase
H2BFS H2B histone family, member S (pseudogene)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA4L heat shock 70kDa protein 4-like
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI44L interferon-induced protein 44-like
ITM2C integral membrane protein 2C
KRT6A keratin 6A, type II
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PLAT plasminogen activator, tissue
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAP prosaposin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
S100A7 S100 calcium binding protein A7
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
STXBP1 syntaxin binding protein 1
TMED2 transmembrane emp24 domain trafficking protein 2
TPD52 tumor protein D52
TSPAN3 tetraspanin 3
TUBB2A tubulin, beta 2A class IIa
WLS wntless Wnt ligand secretion mediator
ZCCHC14 zinc finger, CCHC domain containing 14
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BZW2 basic leucine zipper and W2 domains 2
CALB1 calbindin 1, 28kDa
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
COL6A3 collagen, type VI, alpha 3
CRYAB crystallin, alpha B
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
FXYD5 FXYD domain containing ion transport regulator 5
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HGD homogentisate 1,2-dioxygenase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
KANK1 KN motif and ankyrin repeat domains 1
KRT23 keratin 23, type I
LXN latexin
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
PAX8 paired box 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
S100P S100 calcium binding protein P
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SORBS3 sorbin and SH3 domain containing 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE2 transducin-like enhancer of split 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
Funding