BRD-U33728988_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-U33728988_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DNMBP dynamin binding protein
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FOSL1 FOS-like antigen 1
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HK1 hexokinase 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IER2 immediate early response 2
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INPP1 inositol polyphosphate-1-phosphatase
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
SFRP4 secreted frizzled-related protein 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SORBS2 sorbin and SH3 domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TRIB1 tribbles pseudokinase 1
TXNL4B thioredoxin-like 4B
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZCCHC6 zinc finger, CCHC domain containing 6

decreased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ADA adenosine deaminase
BLMH bleomycin hydrolase
CA12 carbonic anhydrase XII
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR1 carbonyl reductase 1
CETN2 centrin, EF-hand protein, 2
CLNS1A chloride channel, nucleotide-sensitive, 1A
COCH cochlin
CTTN cortactin
CYB5A cytochrome b5 type A (microsomal)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FCGBP Fc fragment of IgG binding protein
FKBP9 FK506 binding protein 9, 63 kDa
FOLR1 folate receptor 1 (adult)
HBB hemoglobin, beta
HMGN3 high mobility group nucleosomal binding domain 3
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KANK2 KN motif and ankyrin repeat domains 2
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
LAMC1 laminin, gamma 1 (formerly LAMB2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFSD10 major facilitator superfamily domain containing 10
MLANA melan-A
NDN necdin, melanoma antigen (MAGE) family member
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPEPL1 aminopeptidase-like 1
NXN nucleoredoxin
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RPS11 ribosomal protein S11
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SFN stratifin
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFRC transferrin receptor
TM7SF2 transmembrane 7 superfamily member 2
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
Funding