BRD-U37049823_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-U37049823_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADIRF adipogenesis regulatory factor
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CXCL10 chemokine (C-X-C motif) ligand 10
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EIF5A eukaryotic translation initiation factor 5A
FOLR1 folate receptor 1 (adult)
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GPM6B glycoprotein M6B
GSE1 Gse1 coiled-coil protein
GSTA1 glutathione S-transferase alpha 1
H1FX H1 histone family, member X
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
ISYNA1 inositol-3-phosphate synthase 1
MFSD10 major facilitator superfamily domain containing 10
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MZB1 marginal zone B and B1 cell-specific protein
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NUPR1 nuclear protein, transcriptional regulator, 1
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PMM1 phosphomannomutase 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB1D2 secretoglobin, family 1D, member 2
SEPW1 selenoprotein W, 1
SFRP4 secreted frizzled-related protein 4
SPRED2 sprouty-related, EVH1 domain containing 2
TMPRSS3 transmembrane protease, serine 3
TNNC1 troponin C type 1 (slow)
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ACSL1 acyl-CoA synthetase long-chain family member 1
ADRB2 adrenoceptor beta 2, surface
AK4 adenylate kinase 4
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAST calpastatin
CCND1 cyclin D1
CD99 CD99 molecule
CPVL carboxypeptidase, vitellogenic-like
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CST1 cystatin SN
CTSB cathepsin B
CTSH cathepsin H
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA2 EPH receptor A2
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GAS2L1 growth arrest-specific 2 like 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
IER3 immediate early response 3
IL6ST interleukin 6 signal transducer
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
MARCKS myristoylated alanine-rich protein kinase C substrate
MCOLN1 mucolipin 1
MGST2 microsomal glutathione S-transferase 2
MIR22HG MIR22 host gene
NPY neuropeptide Y
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLXNC1 plexin C1
PRSS23 protease, serine, 23
PTX3 pentraxin 3, long
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS4 regulator of G-protein signaling 4
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TACC1 transforming, acidic coiled-coil containing protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)