BRD-U43867373_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-U43867373_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
BTK Bruton agammaglobulinemia tyrosine kinase
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CD69 CD69 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLEC7A C-type lectin domain family 7, member A
CPA3 carboxypeptidase A3 (mast cell)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
ECI1 enoyl-CoA delta isomerase 1
ELOVL2 ELOVL fatty acid elongase 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
GAS1 growth arrest-specific 1
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GREB1 growth regulation by estrogen in breast cancer 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IL32 interleukin 32
INSIG1 insulin induced gene 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
KIF20A kinesin family member 20A
MAP3K8 mitogen-activated protein kinase kinase kinase 8
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
NCF4 neutrophil cytosolic factor 4, 40kDa
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POU2AF1 POU class 2 associating factor 1
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TPD52L1 tumor protein D52-like 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA5 annexin A5
ARHGAP29 Rho GTPase activating protein 29
BBX bobby sox homolog (Drosophila)
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CHGB chromogranin B
COL5A2 collagen, type V, alpha 2
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL2 dihydropyrimidinase-like 2
DST dystonin
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GLIPR1 GLI pathogenesis-related 1
GNAS GNAS complex locus
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KCTD12 potassium channel tetramerization domain containing 12
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LIPG lipase, endothelial
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOK MOK protein kinase
NTM neurotrimin
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
S100A10 S100 calcium binding protein A10
SCG2 secretogranin II
SCG3 secretogranin III
SMAD7 SMAD family member 7
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TGFBI transforming growth factor, beta-induced, 68kDa