BRD-U51024685_HG-6-64-01_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

217 genes differentially expressed following the BRD-U51024685_HG-6-64-01_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANK2 ankyrin 2, neuronal
ANKMY2 ankyrin repeat and MYND domain containing 2
ANXA4 annexin A4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BGN biglycan
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CARS cysteinyl-tRNA synthetase
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CD163 CD163 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL14A1 collagen, type XIV, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTH cystathionine gamma-lyase
CTSA cathepsin A
CTSK cathepsin K
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCLK1 doublecortin-like kinase 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DEPTOR DEP domain containing MTOR-interacting protein
EAPP E2F-associated phosphoprotein
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
ESYT1 extended synaptotagmin-like protein 1
FAM129A family with sequence similarity 129, member A
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LUM lumican
LXN latexin
LY96 lymphocyte antigen 96
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MSRB2 methionine sulfoxide reductase B2
MTSS1 metastasis suppressor 1
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
PAM peptidylglycine alpha-amidating monooxygenase
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLA2G16 phospholipase A2, group XVI
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PYCARD PYD and CARD domain containing
PYCR1 pyrroline-5-carboxylate reductase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A11 S100 calcium binding protein A11
SARS seryl-tRNA synthetase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC22A18 solute carrier family 22, member 18
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBS2 thrombospondin 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VCAN versican
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX15B arachidonate 15-lipoxygenase, type B
ANPEP alanyl (membrane) aminopeptidase
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CENPU centromere protein U
COL4A2 collagen, type IV, alpha 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSV cathepsin V
CYTL1 cytokine-like 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HELLS helicase, lymphoid-specific
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
KIF18B kinesin family member 18B
KLK10 kallikrein-related peptidase 10
KLK7 kallikrein-related peptidase 7
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MOK MOK protein kinase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPD3 non-SMC condensin II complex, subunit D3
NUP155 nucleoporin 155kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1IP1 PAK1 interacting protein 1
PBK PDZ binding kinase
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PI3 peptidase inhibitor 3, skin-derived
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPF4 pre-mRNA processing factor 4
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC4 syndecan 4
SERHL2 serine hydrolase-like 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNRPG small nuclear ribonucleoprotein polypeptide G
SOX9 SRY (sex determining region Y)-box 9
SPRR3 small proline-rich protein 3
SRSF7 serine/arginine-rich splicing factor 7
STK10 serine/threonine kinase 10
TEX30 testis expressed 30
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
Funding