BRD-U51951544_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-U51951544_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD17A abhydrolase domain containing 17A
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ANGPTL2 angiopoietin-like 2
APEH acylaminoacyl-peptide hydrolase
AQP1 aquaporin 1 (Colton blood group)
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATF3 activating transcription factor 3
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
C3 complement component 3
C9ORF16 chromosome 9 open reading frame 16
CALD1 caldesmon 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CD177 CD177 molecule
CD47 CD47 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFB complement factor B
CFH complement factor H
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CLU clusterin
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CYR61 cysteine-rich, angiogenic inducer, 61
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHCR24 24-dehydrocholesterol reductase
DPP4 dipeptidyl-peptidase 4
EGR1 early growth response 1
EID1 EP300 interacting inhibitor of differentiation 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ENO1 enolase 1, (alpha)
FABP1 fatty acid binding protein 1, liver
FILIP1L filamin A interacting protein 1-like
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LY6E lymphocyte antigen 6 complex, locus E
LYN LYN proto-oncogene, Src family tyrosine kinase
MAGED2 melanoma antigen family D2
MAOA monoamine oxidase A
MEF2A myocyte enhancer factor 2A
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MYO1D myosin ID
MYO5C myosin VC
MYO6 myosin VI
NLRP2 NLR family, pyrin domain containing 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PAIP1 poly(A) binding protein interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRL platelet-derived growth factor receptor-like
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSENEN presenilin enhancer gamma secretase subunit
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RNF167 ring finger protein 167
RNF43 ring finger protein 43
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSAD2 radical S-adenosyl methionine domain containing 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SNX10 sorting nexin 10
SPARCL1 SPARC-like 1 (hevin)
SQRDL sulfide quinone reductase-like (yeast)
TDO2 tryptophan 2,3-dioxygenase
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ADRB2 adrenoceptor beta 2, surface
ANXA10 annexin A10
ARID1A AT rich interactive domain 1A (SWI-like)
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
C2CD5 C2 calcium-dependent domain containing 5
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN18 claudin 18
CNOT2 CCR4-NOT transcription complex, subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP7 dual specificity phosphatase 7
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELL2 elongation factor, RNA polymerase II, 2
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GEMIN4 gem (nuclear organelle) associated protein 4
GSPT2 G1 to S phase transition 2
HAS2 hyaluronan synthase 2
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KLHL21 kelch-like family member 21
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MEPCE methylphosphate capping enzyme
METTL18 methyltransferase like 18
MID1 midline 1
MRPS2 mitochondrial ribosomal protein S2
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
N4BP2L2 NEDD4 binding protein 2-like 2
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NET1 neuroepithelial cell transforming 1
NOTCH2NL notch 2 N-terminal like
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PALB2 partner and localizer of BRCA2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDCD2 programmed cell death 2
PDGFA platelet-derived growth factor alpha polypeptide
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLIN2 perilipin 2
PTX3 pentraxin 3, long
PURA purine-rich element binding protein A
RBM15 RNA binding motif protein 15
RBM47 RNA binding motif protein 47
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A11 S100 calcium binding protein A11
SAP30 Sin3A-associated protein, 30kDa
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD7 SMAD family member 7
SOCS5 suppressor of cytokine signaling 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TLR4 toll-like receptor 4
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53BP2 tumor protein p53 binding protein 2
TSPYL5 TSPY-like 5
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCK2 uridine-cytidine kinase 2
UQCRH ubiquinol-cytochrome c reductase hinge protein
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18