BRD-U51951544_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-U51951544_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
ATM ATM serine/threonine kinase
BSG basigin (Ok blood group)
CD24 CD24 molecule
CFB complement factor B
CFH complement factor H
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
DHCR24 24-dehydrocholesterol reductase
DMXL2 Dmx-like 2
EFHD1 EF-hand domain family, member D1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MXRA5 matrix-remodelling associated 5
MYOF myoferlin
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RCAN2 regulator of calcineurin 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCARB2 scavenger receptor class B, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SKP1 S-phase kinase-associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNX10 sorting nexin 10
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
TLR4 toll-like receptor 4
TMPRSS3 transmembrane protease, serine 3
TPSAB1 tryptase alpha/beta 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSRP1 cysteine and glycine-rich protein 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFNA1 ephrin-A1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6R interleukin 6 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIF2A kinesin heavy chain member 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT17 keratin 17, type I
LSG1 large 60S subunit nuclear export GTPase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MALT1 MALT1 paracaspase
MED17 mediator complex subunit 17
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MIS12 MIS12 kinetochore complex component
MSH6 mutS homolog 6
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUP88 nucleoporin 88kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PALLD palladin, cytoskeletal associated protein
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PRPF4 pre-mRNA processing factor 4
PRUNE prune exopolyphosphatase
RANBP6 RAN binding protein 6
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SRGN serglycin
STK17A serine/threonine kinase 17a
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX3 T-box 3
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOB2 transducer of ERBB2, 2
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
UBE2G1 ubiquitin-conjugating enzyme E2G 1
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF281 zinc finger protein 281
ZYX zyxin
Funding