BRD-U60236422_WH-4-025_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-U60236422_WH-4-025_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
BST2 bone marrow stromal cell antigen 2
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
CADM1 cell adhesion molecule 1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH19 cadherin 19, type 2
CEMIP cell migration inducing protein, hyaluronan binding
CLU clusterin
COLEC12 collectin sub-family member 12
CTSA cathepsin A
DAAM2 dishevelled associated activator of morphogenesis 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FUCA1 fucosidase, alpha-L- 1, tissue
GAS6 growth arrest-specific 6
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD5 potassium channel tetramerization domain containing 5
L1CAM L1 cell adhesion molecule
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
LPIN1 lipin 1
METTL7A methyltransferase like 7A
MMP2 matrix metallopeptidase 2
MTSS1 metastasis suppressor 1
MVP major vault protein
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDZRN3 PDZ domain containing ring finger 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLXNB2 plexin B2
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPRT quinolinate phosphoribosyltransferase
RHOQ ras homolog family member Q
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100B S100 calcium binding protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCRG1 stimulator of chondrogenesis 1
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORBS2 sorbin and SH3 domain containing 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SV2C synaptic vesicle glycoprotein 2C
TAC1 tachykinin, precursor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TMEM35 transmembrane protein 35
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AK4 adenylate kinase 4
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CAMP cathelicidin antimicrobial peptide
CCNA2 cyclin A2
CCNB1 cyclin B1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
CTSG cathepsin G
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EGR1 early growth response 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HBD hemoglobin, delta
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HOXC6 homeobox C6
IER2 immediate early response 2
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KIF18B kinesin family member 18B
KRT5 keratin 5, type II
LMNB1 lamin B1
LMO4 LIM domain only 4
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MKI67 marker of proliferation Ki-67
MMP1 matrix metallopeptidase 1
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK2 NIMA-related kinase 2
NUP85 nucleoporin 85kDa
NUSAP1 nucleolar and spindle associated protein 1
ODC1 ornithine decarboxylase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RACGAP1 Rac GTPase activating protein 1
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHCBP1 SHC SH2-domain binding protein 1
SLC25A46 solute carrier family 25, member 46
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding