BRD-U60236422_WH-4-025_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-U60236422_WH-4-025_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMACR alpha-methylacyl-CoA racemase
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
CCL5 chemokine (C-C motif) ligand 5
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CELF2 CUGBP, Elav-like family member 2
CES1 carboxylesterase 1
CLIC5 chloride intracellular channel 5
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMD dystrophin
DTX4 deltex 4, E3 ubiquitin ligase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHB2 EPH receptor B2
FCGBP Fc fragment of IgG binding protein
GOLGA8H golgin A8 family, member H
GSTA4 glutathione S-transferase alpha 4
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KDM5D lysine (K)-specific demethylase 5D
LIMCH1 LIM and calponin homology domains 1
MAP2K6 mitogen-activated protein kinase kinase 6
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MX1 MX dynamin-like GTPase 1
MYH11 myosin, heavy chain 11, smooth muscle
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OLFM4 olfactomedin 4
PDGFD platelet derived growth factor D
PDHX pyruvate dehydrogenase complex, component X
PSAP prosaposin
PTN pleiotrophin
RHOBTB3 Rho-related BTB domain containing 3
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPON1 spondin 1, extracellular matrix protein
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TCTA T-cell leukemia translocation altered
TKT transketolase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
XYLT1 xylosyltransferase I
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ANXA10 annexin A10
ANXA3 annexin A3
COL1A1 collagen, type I, alpha 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
KRT8 keratin 8, type II
LTF lactotransferrin
LYZ lysozyme
NNMT nicotinamide N-methyltransferase
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
RBP1 retinol binding protein 1, cellular
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
VAT1 vesicle amine transport 1
Funding