BRD-U61997977_WZ-4-145_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-U61997977_WZ-4-145_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRG1 adhesion G protein-coupled receptor G1
AIF1 allograft inflammatory factor 1
AKR1C3 aldo-keto reductase family 1, member C3
ALAD aminolevulinate dehydratase
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP3 aquaporin 3 (Gill blood group)
ARMCX6 armadillo repeat containing, X-linked 6
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BST2 bone marrow stromal cell antigen 2
CAPN1 calpain 1, (mu/I) large subunit
CCDC28A coiled-coil domain containing 28A
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CREBL2 cAMP responsive element binding protein-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CTSL cathepsin L
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND2D DENN/MADD domain containing 2D
DHCR24 24-dehydrocholesterol reductase
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FOXJ3 forkhead box J3
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNMT histamine N-methyltransferase
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM3A lysine (K)-specific demethylase 3A
KLHDC2 kelch domain containing 2
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LXN latexin
LYZ lysozyme
MAN2B1 mannosidase, alpha, class 2B, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MERTK MER proto-oncogene, tyrosine kinase
METTL7A methyltransferase like 7A
MSLN mesothelin
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MVP major vault protein
MX2 MX dynamin-like GTPase 2
NBR1 neighbor of BRCA1 gene 1
NMRK1 nicotinamide riboside kinase 1
NNMT nicotinamide N-methyltransferase
NOTCH3 notch 3
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBX1 pre-B-cell leukemia homeobox 1
PDZK1IP1 PDZK1 interacting protein 1
PLA2G16 phospholipase A2, group XVI
PLSCR4 phospholipid scramblase 4
POSTN periostin, osteoblast specific factor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKCD protein kinase C, delta
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM47 RNA binding motif protein 47
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RNASET2 ribonuclease T2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SH3YL1 SH3 and SYLF domain containing 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A4 solute carrier family 16, member 4
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRGN serglycin
STAB1 stabilin 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS1 tensin 1
TOB1 transducer of ERBB2, 1
TRAK2 trafficking protein, kinesin binding 2
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRIM38 tripartite motif containing 38
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAMP8 vesicle-associated membrane protein 8
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AREG amphiregulin
BMP2 bone morphogenetic protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BZW2 basic leucine zipper and W2 domains 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC86 coiled-coil domain containing 86
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CLTB clathrin, light chain B
COTL1 coactosin-like F-actin binding protein 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DKC1 dyskeratosis congenita 1, dyskerin
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FKBP1A FK506 binding protein 1A, 12kDa
FOSL1 FOS-like antigen 1
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
H2AFX H2A histone family, member X
HBEGF heparin-binding EGF-like growth factor
HIRA histone cell cycle regulator
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
LPL lipoprotein lipase
MFSD12 major facilitator superfamily domain containing 12
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NT5E 5'-nucleotidase, ecto (CD73)
PA2G4 proliferation-associated 2G4, 38kDa
PBK PDZ binding kinase
PDAP1 PDGFA associated protein 1
PFKP phosphofructokinase, platelet
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMP22 peripheral myelin protein 22
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRDX4 peroxiredoxin 4
PRMT1 protein arginine methyltransferase 1
PRSS23 protease, serine, 23
PTRF polymerase I and transcript release factor
RANBP1 RAN binding protein 1
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SATB2 SATB homeobox 2
SDF2L1 stromal cell-derived factor 2-like 1
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC43A3 solute carrier family 43, member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIPIN TIMELESS interacting protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
Funding