BRD-U61997977_WZ-4-145_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-U61997977_WZ-4-145_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ALOX5 arachidonate 5-lipoxygenase
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CAPG capping protein (actin filament), gelsolin-like
CD24 CD24 molecule
CD47 CD47 molecule
CFD complement factor D (adipsin)
CLU clusterin
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FABP4 fatty acid binding protein 4, adipocyte
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GLS glutaminase
GRN granulin
HEG1 heart development protein with EGF-like domains 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
KRT14 keratin 14, type I
L1CAM L1 cell adhesion molecule
MRC2 mannose receptor, C type 2
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NCOA3 nuclear receptor coactivator 3
OXTR oxytocin receptor
PALLD palladin, cytoskeletal associated protein
PIEZO2 piezo-type mechanosensitive ion channel component 2
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBBP8 retinoblastoma binding protein 8
S100A10 S100 calcium binding protein A10
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLPI secretory leukocyte peptidase inhibitor
STC2 stanniocalcin 2
TAGLN transgelin
THY1 Thy-1 cell surface antigen
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNNT1 troponin T type 1 (skeletal, slow)
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TUFT1 tuftelin 1
UBQLN2 ubiquilin 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAT1 vesicle amine transport 1
VSNL1 visinin-like 1
WT1 Wilms tumor 1
ZC3HAV1 zinc finger CCCH-type, antiviral 1

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CALML4 calmodulin-like 4
CD320 CD320 molecule
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
COL15A1 collagen, type XV, alpha 1
COL9A3 collagen, type IX, alpha 3
COPS7A COP9 signalosome subunit 7A
CRELD2 cysteine-rich with EGF-like domains 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DACH1 dachshund family transcription factor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EHF ets homologous factor
ENO1 enolase 1, (alpha)
FGL2 fibrinogen-like 2
GLUL glutamate-ammonia ligase
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GOLM1 golgi membrane protein 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIAA0125 KIAA0125
KLF9 Kruppel-like factor 9
KLHDC2 kelch domain containing 2
LDHB lactate dehydrogenase B
LMO4 LIM domain only 4
LPAR6 lysophosphatidic acid receptor 6
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGEB2 melanoma antigen family B2
MAP7 microtubule-associated protein 7
MCTP1 multiple C2 domains, transmembrane 1
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MYB v-myb avian myeloblastosis viral oncogene homolog
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
PDAP1 PDGFA associated protein 1
PDHX pyruvate dehydrogenase complex, component X
PHB2 prohibitin 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
REG1A regenerating islet-derived 1 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
SDF2L1 stromal cell-derived factor 2-like 1
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD1 SMAD family member 1
SPAG4 sperm associated antigen 4
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
THAP11 THAP domain containing 11
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN8 tetraspanin 8
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZEB1 zinc finger E-box binding homeobox 1
Funding