BRD-U61997977_WZ-4-145_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-U61997977_WZ-4-145_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD3 adducin 3 (gamma)
ADGRG1 adhesion G protein-coupled receptor G1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
APLP2 amyloid beta (A4) precursor-like protein 2
ASPN asporin
AVPI1 arginine vasopressin-induced 1
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFB complement factor B
CFD complement factor D (adipsin)
CLDN7 claudin 7
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSD cathepsin D
CTSK cathepsin K
DCN decorin
ECM1 extracellular matrix protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMP1 epithelial membrane protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FBN1 fibrillin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAS1 growth arrest-specific 1
GM2A GM2 ganglioside activator
GSN gelsolin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IRF6 interferon regulatory factor 6
ISG15 ISG15 ubiquitin-like modifier
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KYNU kynureninase
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LXN latexin
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NMU neuromedin U
NUPR1 nuclear protein, transcriptional regulator, 1
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPTN optineurin
ORAI3 ORAI calcium release-activated calcium modulator 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PDZD2 PDZ domain containing 2
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PRSS8 protease, serine, 8
PTGES prostaglandin E synthase
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
RAB25 RAB25, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A14 S100 calcium binding protein A14
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPRR3 small proline-rich protein 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAGLN transgelin
TCEAL4 transcription elongation factor A (SII)-like 4
TCF4 transcription factor 4
TERT telomerase reverse transcriptase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP2 TIMP metallopeptidase inhibitor 2
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRBC1 T cell receptor beta constant 1
TRIM22 tripartite motif containing 22
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
VCAN versican
VNN1 vanin 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CENPA centromere protein A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DLK1 delta-like 1 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EREG epiregulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HHEX hematopoietically expressed homeobox
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
MRPS2 mitochondrial ribosomal protein S2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NRG1 neuregulin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP2 poly (ADP-ribose) polymerase 2
PCDH9 protocadherin 9
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
PRAME preferentially expressed antigen in melanoma
PRPF4 pre-mRNA processing factor 4
PTX3 pentraxin 3, long
RFC2 replication factor C (activator 1) 2, 40kDa
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
SACS sacsin molecular chaperone
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SRM spermidine synthase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
Funding