BRD-U64289953_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

99 genes differentially expressed following the BRD-U64289953_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRL2 adhesion G protein-coupled receptor L2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD10 ankyrin repeat domain 10
BEX1 brain expressed, X-linked 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
CLCA2 chloride channel accessory 2
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CST1 cystatin SN
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
G6PD glucose-6-phosphate dehydrogenase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFNGR1 interferon gamma receptor 1
KIF1BP KIF1 binding protein
KRCC1 lysine-rich coiled-coil 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RET ret proto-oncogene
RNF167 ring finger protein 167
RPS5 ribosomal protein S5
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGK1 serum/glucocorticoid regulated kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
SQLE squalene epoxidase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM97 transmembrane protein 97
TXNDC9 thioredoxin domain containing 9
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BZW2 basic leucine zipper and W2 domains 2
CA12 carbonic anhydrase XII
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CFI complement factor I
CLNS1A chloride channel, nucleotide-sensitive, 1A
CNPY3 canopy FGF signaling regulator 3
COL6A2 collagen, type VI, alpha 2
DCK deoxycytidine kinase
DUSP2 dual specificity phosphatase 2
DUSP22 dual specificity phosphatase 22
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
FOXG1 forkhead box G1
FXYD5 FXYD domain containing ion transport regulator 5
GNAS GNAS complex locus
GPM6A glycoprotein M6A
GPR171 G protein-coupled receptor 171
HOMER2 homer scaffolding protein 2
HSPB1 heat shock 27kDa protein 1
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KLF6 Kruppel-like factor 6
PAX6 paired box 6
PECR peroxisomal trans-2-enoyl-CoA reductase
PPT1 palmitoyl-protein thioesterase 1
PRAME preferentially expressed antigen in melanoma
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TPPP3 tubulin polymerization-promoting protein family member 3
TSC22D1 TSC22 domain family, member 1
Funding