BRD-U64289953_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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51 genes differentially expressed following the BRD-U64289953_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHSG alpha-2-HS-glycoprotein
ALDOC aldolase C, fructose-bisphosphate
CADM1 cell adhesion molecule 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CEMIP cell migration inducing protein, hyaluronan binding
CLU clusterin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
ETV5 ets variant 5
FST follistatin
H2BFS H2B histone family, member S (pseudogene)
HIST2H2BE histone cluster 2, H2be
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KIAA0226L KIAA0226-like
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPIN1 lipin 1
MYO1B myosin IB
NT5E 5'-nucleotidase, ecto (CD73)
RGS2 regulator of G-protein signaling 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TBX3 T-box 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
CTSH cathepsin H
CYB561 cytochrome b561
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FBP1 fructose-1,6-bisphosphatase 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFRD2 interferon-related developmental regulator 2
METTL9 methyltransferase like 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PON2 paraoxonase 2
PUF60 poly-U binding splicing factor 60KDa
RGS5 regulator of G-protein signaling 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SPDEF SAM pointed domain containing ETS transcription factor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)