BRD-U64521890_XMD16-144_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-U64521890_XMD16-144_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
CCDC85B coiled-coil domain containing 85B
CCL20 chemokine (C-C motif) ligand 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HOOK2 hook microtubule-tethering protein 2
KIAA0485 uncharacterized LOC57235
KRT13 keratin 13, type I
KRT15 keratin 15, type I
N4BP2L2 NEDD4 binding protein 2-like 2
NSG1 neuron specific gene family member 1
PI3 peptidase inhibitor 3, skin-derived
PLCB4 phospholipase C, beta 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A7 S100 calcium binding protein A7
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
ST7 suppression of tumorigenicity 7
TGFBR3 transforming growth factor, beta receptor III
TRA2A transformer 2 alpha homolog (Drosophila)
TTC39A tetratricopeptide repeat domain 39A

decreased expression

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AUTS2 autism susceptibility candidate 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BGN biglycan
C4BPA complement component 4 binding protein, alpha
C5 complement component 5
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CST4 cystatin S
CXCL14 chemokine (C-X-C motif) ligand 14
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FXYD5 FXYD domain containing ion transport regulator 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPER1 G protein-coupled estrogen receptor 1
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
NNMT nicotinamide N-methyltransferase
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTS neurotensin
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD51 RAD51 recombinase
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RRM2 ribonucleotide reductase M2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNAP25 synaptosomal-associated protein, 25kDa
SRGN serglycin
SYT1 synaptotagmin I
TCF4 transcription factor 4
TFR2 transferrin receptor 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4
TSC22D3 TSC22 domain family, member 3
VCAN versican
WIPF1 WAS/WASL interacting protein family, member 1
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
Funding