BRD-U68942961_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-U68942961_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG6 adhesion G protein-coupled receptor G6
AMDHD2 amidohydrolase domain containing 2
ANK2 ankyrin 2, neuronal
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C6ORF48 chromosome 6 open reading frame 48
CCL2 chemokine (C-C motif) ligand 2
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSK cathepsin K
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
EFNA1 ephrin-A1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
ICAM1 intercellular adhesion molecule 1
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KYNU kynureninase
LOC100505650 uncharacterized LOC100505650
MAP7 microtubule-associated protein 7
MTMR11 myotubularin related protein 11
NAV2 neuron navigator 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRL platelet-derived growth factor receptor-like
PEG3 paternally expressed 3
PLK1 polo-like kinase 1
PNKP polynucleotide kinase 3'-phosphatase
PRAME preferentially expressed antigen in melanoma
RAP1GAP2 RAP1 GTPase activating protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCAND1 SCAN domain containing 1
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP4 secreted frizzled-related protein 4
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRPS1 trichorhinophalangeal syndrome I
WFDC1 WAP four-disulfide core domain 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APLP2 amyloid beta (A4) precursor-like protein 2
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AXL AXL receptor tyrosine kinase
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCND1 cyclin D1
CCND2 cyclin D2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRYZ crystallin, zeta (quinone reductase)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHB2 EPH receptor B2
FAM3C family with sequence similarity 3, member C
FSTL1 follistatin-like 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
KANK2 KN motif and ankyrin repeat domains 2
KCTD12 potassium channel tetramerization domain containing 12
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL2 lysyl oxidase-like 2
MET MET proto-oncogene, receptor tyrosine kinase
P4HB prolyl 4-hydroxylase, beta polypeptide
PDIA3 protein disulfide isomerase family A, member 3
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PMEPA1 prostate transmembrane protein, androgen induced 1
PRSS23 protease, serine, 23
PXDN peroxidasin
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAB1 stabilin 1
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIM14 tripartite motif containing 14
TUBB6 tubulin, beta 6 class V