BRD-U74615290_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-U74615290_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CTGF connective tissue growth factor
DEFA4 defensin, alpha 4, corticostatin
EMP1 epithelial membrane protein 1
FHOD3 formin homology 2 domain containing 3
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JAG1 jagged 1
MXRA5 matrix-remodelling associated 5
OLFM4 olfactomedin 4
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCG2 secretogranin II
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SST somatostatin
TAGLN transgelin
TBX3 T-box 3
THBS1 thrombospondin 1

decreased expression

Symbol Name
ATF5 activating transcription factor 5
BCAS3 breast carcinoma amplified sequence 3
BPTF bromodomain PHD finger transcription factor
CD58 CD58 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
FBP1 fructose-1,6-bisphosphatase 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABPB1 GA binding protein transcription factor, beta subunit 1
GTPBP8 GTP-binding protein 8 (putative)
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMG20B high mobility group 20B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
JMJD6 jumonji domain containing 6
LAT2 linker for activation of T cells family, member 2
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
MYH10 myosin, heavy chain 10, non-muscle
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PHACTR2 phosphatase and actin regulator 2
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
SGK1 serum/glucocorticoid regulated kinase 1
TUBD1 tubulin, delta 1
UBE3B ubiquitin protein ligase E3B