BRD-U82589721_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-U82589721_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
CA2 carbonic anhydrase II
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CCNA1 cyclin A1
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLEC10A C-type lectin domain family 10, member A
CLEC11A C-type lectin domain family 11, member A
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CTSG cathepsin G
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
DEFA4 defensin, alpha 4, corticostatin
DSP desmoplakin
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR2 early growth response 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPS8L1 EPS8-like 1
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL32 interleukin 32
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFML2A olfactomedin-like 2A
PDLIM3 PDZ and LIM domain 3
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXDN peroxidasin
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SFRP4 secreted frizzled-related protein 4
SLC38A1 solute carrier family 38, member 1
STC2 stanniocalcin 2
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TUBA1A tubulin, alpha 1a
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
CCNA2 cyclin A2
CCND1 cyclin D1
CD58 CD58 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIAPIN1 cytokine induced apoptosis inhibitor 1
CSNK1A1 casein kinase 1, alpha 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDNRB endothelin receptor type B
EIF5 eukaryotic translation initiation factor 5
EPHA3 EPH receptor A3
FAM57A family with sequence similarity 57, member A
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
MRPS2 mitochondrial ribosomal protein S2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NRN1 neuritin 1
NUSAP1 nucleolar and spindle associated protein 1
PDGFA platelet-derived growth factor alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RRM2 ribonucleotide reductase M2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SNX11 sorting nexin 11
SPINK1 serine peptidase inhibitor, Kazal type 1
TBP TATA box binding protein
TMEM100 transmembrane protein 100
TMEM5 transmembrane protein 5
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9