BRD-U86222656_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-U86222656_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDOC aldolase C, fructose-bisphosphate
ANKRD36B ankyrin repeat domain 36B
ATF3 activating transcription factor 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CXCL2 chemokine (C-X-C motif) ligand 2
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF5A eukaryotic translation initiation factor 5A
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
HMOX1 heme oxygenase 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLHL24 kelch-like family member 24
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCDH9 protocadherin 9
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRC protein tyrosine phosphatase, receptor type, C
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SULF1 sulfatase 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIF1 WNT inhibitory factor 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AIM1 absent in melanoma 1
CBR3 carbonyl reductase 3
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCA4 cell division cycle associated 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DNM1L dynamin 1-like
DUSP4 dual specificity phosphatase 4
FAM57A family with sequence similarity 57, member A
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
JADE1 jade family PHD finger 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK6 mitogen-activated protein kinase 6
NID1 nidogen 1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PRPF4 pre-mRNA processing factor 4
PRSS23 protease, serine, 23
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TMEM2 transmembrane protein 2
VCAN versican
WDR61 WD repeat domain 61
Funding