BRD-U86922168_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-U86922168_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
ANXA5 annexin A5
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
BCL2A1 BCL2-related protein A1
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BRD8 bromodomain containing 8
BST2 bone marrow stromal cell antigen 2
C1ORF27 chromosome 1 open reading frame 27
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL9A2 collagen, type IX, alpha 2
COMP cartilage oligomeric matrix protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGR1 early growth response 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IL6 interleukin 6
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KYNU kynureninase
LDLR low density lipoprotein receptor
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MCOLN1 mucolipin 1
MIR22HG MIR22 host gene
N4BP2L2 NEDD4 binding protein 2-like 2
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NEU1 sialidase 1 (lysosomal sialidase)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NPC1 Niemann-Pick disease, type C1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PER2 period circadian clock 2
PLAC8 placenta-specific 8
PROM1 prominin 1
PSAP prosaposin
PSPC1 paraspeckle component 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD9A RAD9 homolog A (S. pombe)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RSRC2 arginine/serine-rich coiled-coil 2
SDC4 syndecan 4
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SYNGR3 synaptogyrin 3
TEX10 testis expressed 10
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TREM1 triggering receptor expressed on myeloid cells 1
TXNL4B thioredoxin-like 4B
VCAN versican
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
ALDOA aldolase A, fructose-bisphosphate
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARMCX2 armadillo repeat containing, X-linked 2
ASPH aspartate beta-hydroxylase
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
CA12 carbonic anhydrase XII
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAPNS1 calpain, small subunit 1
CAV2 caveolin 2
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DSP desmoplakin
EFS embryonal Fyn-associated substrate
EHBP1 EH domain binding protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENG endoglin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FXYD5 FXYD domain containing ion transport regulator 5
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
HAMP hepcidin antimicrobial peptide
HBB hemoglobin, beta
IGL immunoglobulin lambda locus
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KIAA1033 KIAA1033
KRT5 keratin 5, type II
LASP1 LIM and SH3 protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LUM lumican
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MYO1B myosin IB
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPEPL1 aminopeptidase-like 1
OLFML3 olfactomedin-like 3
PCP4 Purkinje cell protein 4
PEBP1 phosphatidylethanolamine binding protein 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSD3 pleckstrin and Sec7 domain containing 3
RAB11A RAB11A, member RAS oncogene family
RHOB ras homolog family member B
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D16 TBC1 domain family, member 16
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBCB tubulin folding cofactor B
TCF4 transcription factor 4
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM147 transmembrane protein 147
TPD52L1 tumor protein D52-like 1
TPM4 tropomyosin 4
TRIM22 tripartite motif containing 22
TUBB tubulin, beta class I
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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