BRD-U88459701_atorvastatin_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

296 genes differentially expressed following the BRD-U88459701_atorvastatin_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ANXA4 annexin A4
ARMCX2 armadillo repeat containing, X-linked 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDH13 cadherin 13
CDH19 cadherin 19, type 2
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES2 carboxylesterase 2
CHD9 chromodomain helicase DNA binding protein 9
COBL cordon-bleu WH2 repeat protein
COPA coatomer protein complex, subunit alpha
CSPG4 chondroitin sulfate proteoglycan 4
CSRP1 cysteine and glycine-rich protein 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DES desmin
DIXDC1 DIX domain containing 1
DUSP4 dual specificity phosphatase 4
DYNLT3 dynein, light chain, Tctex-type 3
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM114A1 family with sequence similarity 114, member A1
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FRY furry homolog (Drosophila)
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GBP2 guanylate binding protein 2, interferon-inducible
GLRX glutaredoxin (thioltransferase)
GSN gelsolin
HAPLN1 hyaluronan and proteoglycan link protein 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDS iduronate 2-sulfatase
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IRF9 interferon regulatory factor 9
ITM2B integral membrane protein 2B
JUN jun proto-oncogene
JUND jun D proto-oncogene
KIAA1033 KIAA1033
KLF4 Kruppel-like factor 4 (gut)
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP10 low density lipoprotein receptor-related protein 10
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED2 melanoma antigen family D2
MEST mesoderm specific transcript
MGLL monoglyceride lipase
MIA melanoma inhibitory activity
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PRAF2 PRA1 domain family, member 2
PRKCD protein kinase C, delta
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
RABAC1 Rab acceptor 1 (prenylated)
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN2 reticulon 2
S100A4 S100 calcium binding protein A4
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOX11 SRY (sex determining region Y)-box 11
STX4 syntaxin 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMCC1 transmembrane and coiled-coil domain family 1
TMEM2 transmembrane protein 2
TNC tenascin C
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN31 tetraspanin 31
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
VCAN versican
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIPF3 Yip1 domain family, member 3
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CD24 CD24 molecule
CD69 CD69 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPI centromere protein I
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CXCL13 chemokine (C-X-C motif) ligand 13
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DEPDC1 DEP domain containing 1
DHFR dihydrofolate reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FANCI Fanconi anemia, complementation group I
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FKBP5 FK506 binding protein 5
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
HADH hydroxyacyl-CoA dehydrogenase
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HLTF helicase-like transcription factor
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPA14 heat shock 70kDa protein 14
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IGFBP7 insulin-like growth factor binding protein 7
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAMPT nicotinamide phosphoribosyltransferase
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC1 NDC1 transmembrane nucleoporin
NDC80 NDC80 kinetochore complex component
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NUP155 nucleoporin 155kDa
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
NXN nucleoredoxin
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
OIP5 Opa interacting protein 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSRC1 proline/serine-rich coiled-coil 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
S100A8 S100 calcium binding protein A8
SEPHS1 selenophosphate synthetase 1
SFPQ splicing factor proline/glutamine-rich
SIVA1 SIVA1, apoptosis-inducing factor
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC19A1 solute carrier family 19 (folate transporter), member 1
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SNRPF small nuclear ribonucleoprotein polypeptide F
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TFAM transcription factor A, mitochondrial
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN6 tetraspanin 6
TTK TTK protein kinase
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCK2 uridine-cytidine kinase 2
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
WT1 Wilms tumor 1
WWC1 WW and C2 domain containing 1
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein
Funding