BRD4 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description bromodomain containing 4|The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 23476)
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Genes

346 genes differentially expressed following the BRD4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TMEM212 transmembrane protein 212 3.55349
CRISP2 cysteine-rich secretory protein 2 3.55349
GJB4 gap junction protein, beta 4, 30.3kDa 3.55349
GJB1 gap junction protein, beta 1, 32kDa 3.55349
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 3.55349
PBOV1 prostate and breast cancer overexpressed 1 3.55349
LIM2 lens intrinsic membrane protein 2, 19kDa 3.55349
SPRR1B small proline-rich protein 1B 3.55349
SFTPB surfactant protein B 3.55349
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 3.55349
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.55349
TM4SF20 transmembrane 4 L six family member 20 3.55349
TCHH trichohyalin 3.55349
LAPTM5 lysosomal protein transmembrane 5 3.55349
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.55349
SOX1 SRY (sex determining region Y)-box 1 3.55349
GPR55 G protein-coupled receptor 55 3.55349
CELF3 CUGBP, Elav-like family member 3 3.55349
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.55349
ADIPOQ adiponectin, C1Q and collagen domain containing 3.55349
CELA3A chymotrypsin-like elastase family, member 3A 3.55349
ZNF662 zinc finger protein 662 3.55349
C1ORF141 chromosome 1 open reading frame 141 3.55349
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 3.55349
PMCH pro-melanin-concentrating hormone 3.55349
CCDC83 coiled-coil domain containing 83 3.55349
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.55349
ABRA actin binding Rho activating protein 3.55349
PITX3 paired-like homeodomain 3 3.55349
CLEC2A C-type lectin domain family 2, member A 3.55349
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.55349
ICAM5 intercellular adhesion molecule 5, telencephalin 3.55349
OR51I2 olfactory receptor, family 51, subfamily I, member 2 3.55349
ARSH arylsulfatase family, member H 3.55349
LOC102724877 uncharacterized LOC102724877 3.55349
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 3.55349
TNS4 tensin 4 3.55349
SMIM5 small integral membrane protein 5 3.55349
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.55349
PRSS36 protease, serine, 36 3.55349
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.55349
ANKK1 ankyrin repeat and kinase domain containing 1 3.55349
LGI1 leucine-rich, glioma inactivated 1 3.55349
KRT77 keratin 77, type II 3.55349
MPO myeloperoxidase 3.55349
GCSAML germinal center-associated, signaling and motility-like 3.55349
SIX6 SIX homeobox 6 3.55349
LRTM3 leucine rich repeat transmembrane protein 3 3.55349
PLPP4 phospholipid phosphatase 4 3.55349
H1-6 H1.6 linker histone, cluster member 3.55349
H2BC1 H2B clustered histone 1 3.55349
SELE selectin E 3.55349
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 3.55349
MCHR1 melanin-concentrating hormone receptor 1 3.55349
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.55349
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 3.55349
MYH1 myosin, heavy chain 1, skeletal muscle, adult 3.55349
GARIN1A golgi associated RAB2 interactor 1A 3.55349
MAJIN membrane anchored junction protein 3.55349
STPG3 sperm-tail PG-rich repeat containing 3 3.55349
CATSPERH catsper channel auxiliary subunit eta 3.55349
SCPPPQ1 secretory calcium-binding phosphoprotein proline-glutamine rich 1 3.55349
SPMIP10 sperm microtubule inner protein 10 3.55349
ZC3H11C zinc finger CCCH-type containing 11C 3.55349
SPMAP2 sperm microtubule associated protein 2 3.55349
PPIAP39 peptidylprolyl isomerase A pseudogene 39 3.55349
C4ORF54 chromosome 4 open reading frame 54 3.55349
EZHIP EZH inhibitory protein 3.55349
PEAK3 PEAK family member 3 3.55349
SPATA31C2 SPATA31 subfamily C, member 2 3.55349
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.55349
TMEM235 transmembrane protein 235 3.55349
SLC22A25 solute carrier family 22, member 25 3.55349
CBLN3 cerebellin 3 precursor 3.55349
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.55349
GOLGA6L2 golgin A6 family-like 2 3.55349
KLHL33 kelch-like family member 33 3.55349
ACTL10 actin-like 10 3.55349
PVRIG poliovirus receptor related immunoglobulin domain containing 3.55349
GRXCR1 glutaredoxin, cysteine rich 1 3.55349
HAPLN2 hyaluronan and proteoglycan link protein 2 3.55349
MIP major intrinsic protein of lens fiber 3.55349
OR2L2 olfactory receptor, family 2, subfamily L, member 2 3.55349
LY6K lymphocyte antigen 6 complex, locus K 3.55349
GCSAM germinal center-associated, signaling and motility 3.55349
F5 coagulation factor V (proaccelerin, labile factor) 3.55349
PCDHGC4 protocadherin gamma subfamily C, 4 3.55349
FGFBP1 fibroblast growth factor binding protein 1 3.55349
OOSP1 oocyte secreted protein 1, pseudogene 3.55349
SBSN suprabasin 3.55349
FOXI2 forkhead box I2 3.55349
SPDYC speedy/RINGO cell cycle regulator family member C 3.55349
PRB1 proline-rich protein BstNI subfamily 1 3.55349
TDRD10 tudor domain containing 10 3.55349
ISL1 ISL LIM homeobox 1 3.55349
C16ORF78 chromosome 16 open reading frame 78 3.55349
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.55349
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 3.55349
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.55349
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.55349
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.55349
LRCOL1 leucine rich colipase-like 1 3.55349
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.55349
PDCD1LG2 programmed cell death 1 ligand 2 3.55349
VAV1 vav 1 guanine nucleotide exchange factor 3.55349
VAX2 ventral anterior homeobox 2 3.55349
SDS serine dehydratase 3.55349
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.55349
CDC20B cell division cycle 20B 3.55349
CTAGE15 CTAGE family, member 15 3.55349
TNN tenascin N 3.55349
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.55349
CD5L CD5 molecule-like 3.55349
PRM1 protamine 1 3.55349
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 3.55349
APOC2 apolipoprotein C-II 3.55349
MAB21L3 mab-21-like 3 (C. elegans) 3.55349
COX7B2 cytochrome c oxidase subunit VIIb2 3.55349
PRR23A proline rich 23A 3.55349
VWA3A von Willebrand factor A domain containing 3A 3.55349
DUOX2 dual oxidase 2 3.55349
CRYBB2 crystallin, beta B2 3.55349
C11ORF96 chromosome 11 open reading frame 96 3.55349
LRRIQ3 leucine-rich repeats and IQ motif containing 3 3.55349
FATE1 fetal and adult testis expressed 1 3.55349
IGLL1 immunoglobulin lambda-like polypeptide 1 3.55349
SLC38A8 solute carrier family 38, member 8 3.55349
SUN3 Sad1 and UNC84 domain containing 3 3.55349
ZPBP zona pellucida binding protein 3.55349
HHIPL2 HHIP-like 2 3.55349
PCDHAC2 protocadherin alpha subfamily C, 2 3.55349
KRT17 keratin 17, type I 3.55349
HPGDS hematopoietic prostaglandin D synthase 3.55349
EOMES eomesodermin 3.55349
MEPE matrix extracellular phosphoglycoprotein 3.55349
LRRC74B leucine rich repeat containing 74B 3.55349
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.55349
PTCRA pre T-cell antigen receptor alpha 3.55349
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 3.55349
CLEC18A C-type lectin domain family 18, member A 3.55349
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.55349
TRIM7 tripartite motif containing 7 3.55349
MMP1 matrix metallopeptidase 1 3.55349
SLITRK1 SLIT and NTRK-like family, member 1 3.55349
GPR17 G protein-coupled receptor 17 3.55349
ANGPTL6 angiopoietin-like 6 3.55349
SLC38A3 solute carrier family 38, member 3 3.55349
PRSS54 protease, serine, 54 3.55349
DMTN dematin actin binding protein 3.55349
AGR2 anterior gradient 2 3.55349
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.55349
IFITM10 interferon induced transmembrane protein 10 3.55349
PF4V1 platelet factor 4 variant 1 3.55349
C5AR2 complement component 5a receptor 2 3.55349
TECRL trans-2,3-enoyl-CoA reductase-like 3.55349
ADAM18 ADAM metallopeptidase domain 18 3.55349
ZBTB20 zinc finger and BTB domain containing 20 3.26849
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 3.14499
GJD3 gap junction protein, delta 3, 31.9kDa 3.08322
FBP2 fructose-1,6-bisphosphatase 2 3.08322
FAM222B family with sequence similarity 222, member B 2.87882
XTBD1 XRN2 binding domain containing 1 2.78034
SGPP1 sphingosine-1-phosphate phosphatase 1 2.74724
BORCS6 BLOC-1 related complex subunit 6 2.71497
PEX13 peroxisomal biogenesis factor 13 2.71249
TOR1AIP2 torsin A interacting protein 2 2.68291
BATF2 basic leucine zipper transcription factor, ATF-like 2 2.68291
TBC1D13 TBC1 domain family, member 13 2.63969
EXOSC3 exosome component 3 2.60551
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) 2.60551
MYOT myotilin 2.559
YIPF7 Yip1 domain family, member 7 2.559
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.559
TRAM2 translocation associated membrane protein 2 2.559
CMKLR1 chemerin chemokine-like receptor 1 2.559
TTBK1 tau tubulin kinase 1 2.559
ASCL3 achaete-scute family bHLH transcription factor 3 2.559
MINDY2 MINDY lysine 48 deubiquitinase 2 2.55024
WEE1 WEE1 G2 checkpoint kinase 2.50248
RMI2 RecQ mediated genome instability 2 2.50248
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.50248
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 2.50248
MED7 mediator complex subunit 7 2.46303
REST RE1-silencing transcription factor 2.43294
TRPV1 transient receptor potential cation channel, subfamily V, member 1 2.42232
RREB1 ras responsive element binding protein 1 2.4036
CNRIP1 cannabinoid receptor interacting protein 1 2.3859
CD52 CD52 molecule 2.33549
CLHC1 clathrin heavy chain linker domain containing 1 2.33549
GP6 glycoprotein VI (platelet) 2.32555
TSNAXIP1 translin-associated factor X interacting protein 1 2.32555
LRRC15 leucine rich repeat containing 15 2.32241
FAM163B family with sequence similarity 163, member B 2.30483
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.30483
SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta 2.30305
CASD1 CAS1 domain containing 1 2.29911
SAMD14 sterile alpha motif domain containing 14 2.29727
NUP205 nucleoporin 205kDa 2.28933
SLC35F4 solute carrier family 35, member F4 2.28793
HIPK2 homeodomain interacting protein kinase 2 2.25207
THOP1 thimet oligopeptidase 1 2.2482
CCDC28B coiled-coil domain containing 28B 2.23988
FIRRM FIGNL1 interacting regulator of recombination and mitosis 2.23126
PTPDC1 protein tyrosine phosphatase domain containing 1 2.22907
PPP4R2 protein phosphatase 4, regulatory subunit 2 2.22907
TRIT1 tRNA isopentenyltransferase 1 2.22907
COL6A3 collagen, type VI, alpha 3 2.22901
COLEC11 collectin sub-family member 11 2.21867
NEMP1 nuclear envelope integral membrane protein 1 2.19134
ATF6 activating transcription factor 6 2.1839
FKRP fukutin related protein 2.17787
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.15982
LGALS7B lectin, galactoside-binding, soluble, 7B 2.12053
MBLAC1 metallo-beta-lactamase domain containing 1 2.12053
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 2.12053
MED12L mediator complex subunit 12-like 2.11767
CRLS1 cardiolipin synthase 1 2.11064
PMPCA peptidase (mitochondrial processing) alpha 2.11064
SRSF7 serine/arginine-rich splicing factor 7 2.10041
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 2.09499
NBR1 neighbor of BRCA1 gene 1 2.09013
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 2.08029
GFUS GDP-L-fucose synthase 2.06768
TMEM185A transmembrane protein 185A 2.06171
SNTG1 syntrophin, gamma 1 2.05238
ZC3H18 zinc finger CCCH-type containing 18 2.04596
PKD1L3 polycystic kidney disease 1-like 3 2.04241
SCYL1 SCY1-like 1 (S. cerevisiae) 2.03992
PCNX4 pecanex 4 2.0288
AGMO alkylglycerol monooxygenase 2.02743
CDC16 cell division cycle 16 2.02684
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.02222
RNF152 ring finger protein 152 2.01304

decreased expression

Symbol Name Standardized Value
ZNF98 zinc finger protein 98 -3.55349
OTX1 orthodenticle homeobox 1 -3.55349
POSTN periostin, osteoblast specific factor -3.55349
VCX3A variable charge, X-linked 3A -3.55349
MMP19 matrix metallopeptidase 19 -3.55349
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -3.55349
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -3.55349
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.55349
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -3.55349
C9ORF57 chromosome 9 open reading frame 57 -3.55349
NPIPB7 nuclear pore complex interacting protein family, member B7 -3.55349
CLEC6A C-type lectin domain family 6, member A -3.55349
STARD6 StAR-related lipid transfer (START) domain containing 6 -3.55349
LGALS4 lectin, galactoside-binding, soluble, 4 -3.55349
F2 coagulation factor II (thrombin) -3.55349
SCARA5 scavenger receptor class A, member 5 -3.55349
ADGRG1 adhesion G protein-coupled receptor G1 -3.55349
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 -3.55349
SLC25A45 solute carrier family 25, member 45 -3.55349
DUSP10 dual specificity phosphatase 10 -3.55349
CCL5 chemokine (C-C motif) ligand 5 -3.55349
PAX3 paired box 3 -3.55349
CCSER1 coiled-coil serine-rich protein 1 -3.55349
SLC9C2 solute carrier family 9, member C2 (putative) -3.55349
HAS1 hyaluronan synthase 1 -3.55349
DRP2 dystrophin related protein 2 -3.55349
KCNK7 potassium channel, two pore domain subfamily K, member 7 -3.55349
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -3.55349
CLDN14 claudin 14 -3.55349
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -3.55349
TEX19 testis expressed 19 -3.55349
DAW1 dynein assembly factor with WDR repeat domains 1 -3.55349
IRF8 interferon regulatory factor 8 -3.55349
CDHR4 cadherin-related family member 4 -3.55349
DPRX divergent-paired related homeobox -3.55349
ACTL6A actin-like 6A -3.55328
CATSPERE catsper channel auxiliary subunit epsilon -3.40215
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -3.27122
FANCL Fanconi anemia, complementation group L -3.06108
LMOD1 leiomodin 1 (smooth muscle) -2.9789
C5ORF58 chromosome 5 open reading frame 58 -2.9789
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.9538
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.94936
SP140L SP140 nuclear body protein-like -2.81326
CFAP141 cilia and flagella associated protein 141 -2.79106
PPA1 pyrophosphatase (inorganic) 1 -2.76583
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -2.75179
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) -2.74982
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.74982
SRP9 signal recognition particle 9kDa -2.63969
SMTN smoothelin -2.6105
N4BP2L1 NEDD4 binding protein 2-like 1 -2.58851
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.5802
ZNF624 zinc finger protein 624 -2.58005
SLIT3 slit homolog 3 (Drosophila) -2.55562
MKI67 marker of proliferation Ki-67 -2.47556
TMEM267 transmembrane protein 267 -2.46337
TANGO6 transport and golgi organization 6 homolog (Drosophila) -2.45578
RAD9B RAD9 homolog B (S. pombe) -2.45264
NRROS negative regulator of reactive oxygen species -2.45264
CRYL1 crystallin, lambda 1 -2.44664
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.38803
ARC activity-regulated cytoskeleton-associated protein -2.38803
SPMIP2 sperm microtubule inner protein 2 -2.38803
ISY1 ISY1 splicing factor homolog (S. cerevisiae) -2.37407
NAP1L3 nucleosome assembly protein 1-like 3 -2.36001
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -2.34861
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -2.33549
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -2.32743
HJURP Holliday junction recognition protein -2.32241
SPATA32 spermatogenesis associated 32 -2.31542
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -2.30911
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) -2.29727
SBNO1 strawberry notch homolog 1 (Drosophila) -2.28893
MBNL1 muscleblind-like splicing regulator 1 -2.28303
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -2.25336
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.25207
RSPO4 R-spondin 4 -2.24722
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -2.24413
RPL10 ribosomal protein L10 -2.23988
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.23988
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.23988
RSRC2 arginine/serine-rich coiled-coil 2 -2.22798
NRG1 neuregulin 1 -2.22681
EPHA5 EPH receptor A5 -2.22528
GPR68 G protein-coupled receptor 68 -2.22528
KLHL34 kelch-like family member 34 -2.21669
CD8B CD8b molecule -2.21669
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) -2.21669
H4C9 H4 clustered histone 9 -2.20264
MAP3K9 mitogen-activated protein kinase kinase kinase 9 -2.19893
MLIP muscular LMNA-interacting protein -2.19134
SPINDOC spindlin interactor and repressor of chromatin binding -2.15796
RWDD1 RWD domain containing 1 -2.15292
AGER advanced glycosylation end product-specific receptor -2.14258
SLC41A3 solute carrier family 41, member 3 -2.12796
TMEM50A transmembrane protein 50A -2.12053
EML5 echinoderm microtubule associated protein like 5 -2.12053
PRPF4 pre-mRNA processing factor 4 -2.10079
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -2.09463
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.08677
FRRS1L ferric-chelate reductase 1-like -2.08029
RHBDL2 rhomboid, veinlet-like 2 (Drosophila) -2.06709
FHL2 four and a half LIM domains 2 -2.05981
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.04867
LDB2 LIM domain binding 2 -2.04596
PDE8A phosphodiesterase 8A -2.04596
SCAMP1 secretory carrier membrane protein 1 -2.04241
TIMELESS timeless circadian clock -2.03241
LRRC8D leucine rich repeat containing 8 family, member D -2.03086
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.02371
MRI1 methylthioribose-1-phosphate isomerase 1 -2.0171
NARS1 asparaginyl-tRNA synthetase 1 -2.00213