BRMS1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description breast cancer metastasis suppressor 1|This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 25855)
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Genes

349 genes differentially expressed following the BRMS1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.11458
KRT17 keratin 17, type I 3.11458
OSTN osteocrin 3.11458
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 3.11458
SVOP SV2 related protein homolog (rat) 3.11458
C20ORF202 chromosome 20 open reading frame 202 3.11458
ALLC allantoicase 3.11458
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 3.11458
CPB2 carboxypeptidase B2 (plasma) 3.11458
ANKRD53 ankyrin repeat domain 53 3.11458
IGFBP7 insulin-like growth factor binding protein 7 3.11458
HNF1B HNF1 homeobox B 3.11458
PNOC prepronociceptin 3.11458
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 3.11458
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.11458
PLET1 placenta expressed transcript 1 3.11458
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.11458
SIGLEC15 sialic acid binding Ig-like lectin 15 3.11458
SBSN suprabasin 3.11458
CNTFR ciliary neurotrophic factor receptor 3.11458
TMPRSS3 transmembrane protease, serine 3 3.11458
MRC1 mannose receptor, C type 1 3.06098
STEAP4 STEAP family member 4 3.06098
C3ORF80 chromosome 3 open reading frame 80 3.06098
SLC39A12 solute carrier family 39 (zinc transporter), member 12 3.06098
HPR haptoglobin-related protein 3.06098
ANXA10 annexin A10 3.06098
TMCO2 transmembrane and coiled-coil domains 2 3.06098
BPIFC BPI fold containing family C 3.06098
ANGPTL3 angiopoietin-like 3 3.06098
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.06098
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 3.06098
SPDEF SAM pointed domain containing ETS transcription factor 3.06098
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.06098
FAM81B family with sequence similarity 81, member B 3.06098
MIA melanoma inhibitory activity 3.06098
DGKE diacylglycerol kinase, epsilon 64kDa 3.06098
CELF6 CUGBP, Elav-like family member 6 3.06098
TGFBR3L transforming growth factor, beta receptor III-like 3.06098
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.06098
NMUR1 neuromedin U receptor 1 3.06098
LOC105378220 macrophage receptor MARCO-like 3.06098
TMPRSS13 transmembrane protease, serine 13 3.06098
MAG myelin associated glycoprotein 3.06098
ATOH1 atonal homolog 1 (Drosophila) 3.06098
GPR26 G protein-coupled receptor 26 3.06098
PBOV1 prostate and breast cancer overexpressed 1 3.06098
ZACN zinc activated ligand-gated ion channel 3.06098
TUBB8 tubulin, beta 8 class VIII 3.06098
PLEK pleckstrin 3.06098
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 3.06098
LRRD1 leucine-rich repeats and death domain containing 1 3.06098
APLN apelin 3.06098
SLC46A2 solute carrier family 46, member 2 3.06098
SPINK4 serine peptidase inhibitor, Kazal type 4 3.06098
PCDHGB3 protocadherin gamma subfamily B, 3 3.06098
CASP4 caspase 4, apoptosis-related cysteine peptidase 3.06098
SPINK6 serine peptidase inhibitor, Kazal type 6 3.06098
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.06098
GPR20 G protein-coupled receptor 20 3.06098
MYOM3 myomesin 3 3.06098
ALPK2 alpha-kinase 2 3.06098
ATOH8 atonal homolog 8 (Drosophila) 3.06098
PTK6 protein tyrosine kinase 6 3.06098
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.06098
MUC20 mucin 20, cell surface associated 3.06098
S100A1 S100 calcium binding protein A1 3.06098
ACVRL1 activin A receptor type II-like 1 3.06098
CHRD chordin 3.06098
TMIE transmembrane inner ear 3.06098
ACR acrosin 3.06098
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.06098
TMPRSS11F transmembrane protease, serine 11F 3.06098
NOTUM notum pectinacetylesterase homolog (Drosophila) 3.06098
ADGB androglobin 3.06098
LAPTM5 lysosomal protein transmembrane 5 3.06098
CELA3A chymotrypsin-like elastase family, member 3A 3.06098
THEM5 thioesterase superfamily member 5 3.06098
NLRP14 NLR family, pyrin domain containing 14 3.06098
SPATA46 spermatogenesis associated 46 3.06098
CCDC198 coiled-coil domain containing 198 3.06098
CAPSL calcyphosine-like 3.06098
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.06098
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 3.06098
QRFP pyroglutamylated RFamide peptide 3.06098
FRG2C FSHD region gene 2 family, member C 3.06098
GPR68 G protein-coupled receptor 68 3.06098
LYZ lysozyme 3.06098
RETN resistin 3.06098
CKM creatine kinase, muscle 3.06098
VSTM1 V-set and transmembrane domain containing 1 3.06098
THBD thrombomodulin 3.06098
COMP cartilage oligomeric matrix protein 3.06098
ERVV-2 endogenous retrovirus group V, member 2 3.06098
DIPK1C divergent protein kinase domain 1C 3.06098
SPMIP10 sperm microtubule inner protein 10 3.06098
GOLGA8R golgin A8 family, member R 3.06098
NOTCH2NLB notch 2 N-terminal like B 3.06098
CTXND1 cortexin domain containing 1 3.06098
SFTA2 surfactant associated 2 3.06098
RHEX regulator of hemoglobinization and erythroid cell expansion 3.06098
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.06098
MEPE matrix extracellular phosphoglycoprotein 3.06098
GAS2L2 growth arrest-specific 2 like 2 3.06098
IL27 interleukin 27 3.06098
EZHIP EZH inhibitory protein 3.06098
PCDHAC2 protocadherin alpha subfamily C, 2 3.06098
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 3.06098
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.06098
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.06098
MYZAP myocardial zonula adherens protein 3.06098
GPR83 G protein-coupled receptor 83 3.06098
EBF2 early B-cell factor 2 3.06098
APOH apolipoprotein H (beta-2-glycoprotein I) 3.06098
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.06098
RASGEF1B RasGEF domain family, member 1B 3.06098
PTH parathyroid hormone 3.06098
FCN3 ficolin (collagen/fibrinogen domain containing) 3 3.06098
BLNK B-cell linker 3.06098
CARD6 caspase recruitment domain family, member 6 3.06098
LST1 leukocyte specific transcript 1 3.06098
MT1M metallothionein 1M 3.06098
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.06098
VCAM1 vascular cell adhesion molecule 1 3.06098
CLCA4 chloride channel accessory 4 3.06098
ASIC3 acid sensing (proton gated) ion channel 3 3.06098
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.06098
NIPAL4 NIPA-like domain containing 4 3.06098
SAG S-antigen; retina and pineal gland (arrestin) 3.06098
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.06098
NOX1 NADPH oxidase 1 3.06098
GLOD5 glyoxalase domain containing 5 3.06098
CYSLTR1 cysteinyl leukotriene receptor 1 3.06098
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.06098
CTAGE9 CTAGE family, member 9 3.06098
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 3.06098
OTC ornithine carbamoyltransferase 3.06098
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 3.06098
PRDM6 PR domain containing 6 3.06098
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.06098
ZNF132 zinc finger protein 132 3.06098
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.06098
SNPH syntaphilin 3.0127
FER1L5 fer-1-like family member 5 3.00449
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.83077
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.83077
AZIN1 antizyme inhibitor 1 2.79873
ARID4B AT rich interactive domain 4B (RBP1-like) 2.76133
LIG4 ligase IV, DNA, ATP-dependent 2.74475
RORB RAR-related orphan receptor B 2.74475
SPATC1 spermatogenesis and centriole associated 1 2.68949
RPL28 ribosomal protein L28 2.67384
TRIM61 tripartite motif containing 61 2.67322
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.65072
RCAN2 regulator of calcineurin 2 2.62959
TUBB3 tubulin, beta 3 class III 2.62959
MAX MYC associated factor X 2.60443
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.60443
PDE4B phosphodiesterase 4B, cAMP-specific 2.58811
ZNF284 zinc finger protein 284 2.5772
CEBPZOS CEBPZ opposite strand 2.56671
CARM1 coactivator-associated arginine methyltransferase 1 2.56671
PPP4R4 protein phosphatase 4, regulatory subunit 4 2.56671
ANKRD45 ankyrin repeat domain 45 2.47402
SAC3D1 SAC3 domain containing 1 2.47238
CEP290 centrosomal protein 290kDa 2.46654
BABAM1 BRISC and BRCA1 A complex member 1 2.4578
IL1R1 interleukin 1 receptor, type I 2.44617
MKI67 marker of proliferation Ki-67 2.43228
IQCE IQ motif containing E 2.41887
FNDC4 fibronectin type III domain containing 4 2.40843
RASA4 RAS p21 protein activator 4 2.40698
EXOSC10 exosome component 10 2.40698
CLSTN1 calsyntenin 1 2.39328
SLC66A2 solute carrier family 66 member 2 2.36153
TUBB4B tubulin, beta 4B class IVb 2.33247
ZNF641 zinc finger protein 641 2.29568
MED27 mediator complex subunit 27 2.28104
SURF6 surfeit 6 2.27361
SIK3 SIK family kinase 3 2.2637
GGNBP2 gametogenetin binding protein 2 2.2637
CEP89 centrosomal protein 89kDa 2.26073
LDB3 LIM domain binding 3 2.26073
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.26073
LRRC28 leucine rich repeat containing 28 2.26073
CDC20B cell division cycle 20B 2.26073
HRH1 histamine receptor H1 2.26073
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.26073
MYL5 myosin, light chain 5, regulatory 2.26073
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 2.26073
KLHL14 kelch-like family member 14 2.25681
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 2.25645
SOCS7 suppressor of cytokine signaling 7 2.2409
SH2D3A SH2 domain containing 3A 2.22613
TRIM11 tripartite motif containing 11 2.22241
ZNF576 zinc finger protein 576 2.22241
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2.22241
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 2.22215
CNTN1 contactin 1 2.19421
TUBGCP6 tubulin, gamma complex associated protein 6 2.18761
ADCY2 adenylate cyclase 2 (brain) 2.18438
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 2.17967
POU2F1 POU class 2 homeobox 1 2.1587
SCAF11 SR-related CTD-associated factor 11 2.15797
APIP APAF1 interacting protein 2.15603
CALCR calcitonin receptor 2.12935
CRYL1 crystallin, lambda 1 2.12855
SFMBT2 Scm-like with four mbt domains 2 2.10725
MIB2 mindbomb E3 ubiquitin protein ligase 2 2.10688
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.0881
INSYN2A inhibitory synaptic factor 2A 2.0867
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 2.08488
TMEM178B transmembrane protein 178B 2.0779
ZNF850 zinc finger protein 850 2.07084
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 2.06679
FRAS1 Fraser extracellular matrix complex subunit 1 2.06676
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.06676
EML2 echinoderm microtubule associated protein like 2 2.06356
CEP20 centrosomal protein 20 2.06356
SSH2 slingshot protein phosphatase 2 2.06208
FAM8A1 family with sequence similarity 8, member A1 2.0609
CBARP CACN subunit beta associated regulatory protein 2.0609
STAMBPL1 STAM binding protein-like 1 2.05677
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.05677
JUND jun D proto-oncogene 2.05654
CCND2 cyclin D2 2.04973
SP4 Sp4 transcription factor 2.04973
MRPL51 mitochondrial ribosomal protein L51 2.04973
C8ORF58 chromosome 8 open reading frame 58 2.04385
CREBRF CREB3 regulatory factor 2.0342
PANX1 pannexin 1 2.0342
SHISA9 shisa family member 9 2.02343
WDR45 WD repeat domain 45 2.00709
ZNF136 zinc finger protein 136 2.00433
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.00094
ACSS2 acyl-CoA synthetase short-chain family member 2 2.00094
FRMD6 FERM domain containing 6 2.00094
ANKRD24 ankyrin repeat domain 24 2.00094

decreased expression

Symbol Name Standardized Value
ZNF470 zinc finger protein 470 -3.11458
PLAC8 placenta-specific 8 -3.11458
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A -3.06098
GIP gastric inhibitory polypeptide -3.06098
ICAM1 intercellular adhesion molecule 1 -3.06098
CABIN1 calcineurin binding protein 1 -2.95176
TIGD6 tigger transposable element derived 6 -2.92327
CDH12 cadherin 12, type 2 (N-cadherin 2) -2.92327
REPIN1 replication initiator 1 -2.91821
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.91434
JAG2 jagged 2 -2.83281
OXTR oxytocin receptor -2.83077
PKDCC protein kinase domain containing, cytoplasmic -2.82235
RBM3 RNA binding motif (RNP1, RRM) protein 3 -2.8169
AVEN apoptosis, caspase activation inhibitor -2.79414
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.74475
PTX3 pentraxin 3, long -2.74475
NLRP1 NLR family, pyrin domain containing 1 -2.74475
ZNF396 zinc finger protein 396 -2.74475
TMEM215 transmembrane protein 215 -2.74475
MPZL2 myelin protein zero-like 2 -2.74475
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) -2.74475
FGF9 fibroblast growth factor 9 -2.74475
GYPE glycophorin E (MNS blood group) -2.74475
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 -2.74475
EPN3 epsin 3 -2.74475
LY6G6D lymphocyte antigen 6 complex, locus G6D -2.74475
RGS11 regulator of G-protein signaling 11 -2.74475
SV2B synaptic vesicle glycoprotein 2B -2.74475
CCNA1 cyclin A1 -2.74475
YPEL4 yippee-like 4 (Drosophila) -2.74475
MYADML2 myeloid-associated differentiation marker-like 2 -2.74475
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.74475
BDKRB2 bradykinin receptor B2 -2.74475
CCDC121 coiled-coil domain containing 121 -2.74475
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 -2.74475
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.74475
RAD51AP2 RAD51 associated protein 2 -2.74475
C17ORF99 chromosome 17 open reading frame 99 -2.74475
CPA2 carboxypeptidase A2 (pancreatic) -2.74475
CYS1 cystin 1 -2.74475
CNGB1 cyclic nucleotide gated channel beta 1 -2.74475
FGFBP1 fibroblast growth factor binding protein 1 -2.74475
ZNF98 zinc finger protein 98 -2.74475
VWA3A von Willebrand factor A domain containing 3A -2.74475
FAM3A family with sequence similarity 3, member A -2.68949
TMUB1 transmembrane and ubiquitin-like domain containing 1 -2.68949
NELFA negative elongation factor complex member A -2.67211
LHCGR luteinizing hormone/choriogonadotropin receptor -2.64561
CLCN1 chloride channel, voltage-sensitive 1 -2.58349
TOP3B topoisomerase (DNA) III beta -2.56671
FCSK fucose kinase -2.53457
PRLR prolactin receptor -2.53168
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -2.52667
CCDC24 coiled-coil domain containing 24 -2.46586
ZDHHC16 zinc finger, DHHC-type containing 16 -2.44346
PMEPA1 prostate transmembrane protein, androgen induced 1 -2.4377
LPCAT1 lysophosphatidylcholine acyltransferase 1 -2.42804
PHYKPL 5-phosphohydroxy-L-lysine phospho-lyase -2.42804
FBXW10B F-box and WD repeat domain containing 10B -2.41887
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.40698
FBXL15 F-box and leucine-rich repeat protein 15 -2.36091
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.32345
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.31129
CIZ1 CDKN1A interacting zinc finger protein 1 -2.31009
NFIC nuclear factor I/C (CCAAT-binding transcription factor) -2.30319
LYRM7 LYR motif containing 7 -2.29092
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -2.26894
TSGA10IP testis specific, 10 interacting protein -2.26168
TNNI3K TNNI3 interacting kinase -2.26168
RHOJ ras homolog family member J -2.26168
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.26073
ENKD1 enkurin domain containing 1 -2.24627
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -2.23963
ZCWPW1 zinc finger, CW type with PWWP domain 1 -2.22215
TEX9 testis expressed 9 -2.21824
C12ORF56 chromosome 12 open reading frame 56 -2.19996
H2AC6 H2A clustered histone 6 -2.17722
JRK Jrk homolog (mouse) -2.15551
CPA6 carboxypeptidase A6 -2.149
NAP1L3 nucleosome assembly protein 1-like 3 -2.14498
NR1I2 nuclear receptor subfamily 1, group I, member 2 -2.14287
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 -2.13286
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -2.12866
FAM110D family with sequence similarity 110, member D -2.11582
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -2.10725
CCDC144A coiled-coil domain containing 144A -2.10577
CD7 CD7 molecule -2.0993
DERL3 derlin 3 -2.08972
LRRC47 leucine rich repeat containing 47 -2.08972
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.0881
NCOA5 nuclear receptor coactivator 5 -2.08496
NUAK1 NUAK family, SNF1-like kinase, 1 -2.0779
KAT14 lysine acetyltransferase 14 -2.06679
ZC3H12C zinc finger CCCH-type containing 12C -2.06679
EGFL7 EGF-like-domain, multiple 7 -2.0609
EIF3I eukaryotic translation initiation factor 3, subunit I -2.0609
RIC8B RIC8 guanine nucleotide exchange factor B -2.05701
MEF2D myocyte enhancer factor 2D -2.05677
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 -2.05677
CYB5A cytochrome b5 type A (microsomal) -2.04973
MNMIP1 manchette microtubule inner protein 1 -2.04973
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.03401
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D -2.03401
GLB1L galactosidase, beta 1-like -2.03401
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -2.03401
PAPPA2 pappalysin 2 -2.03224
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.01378
LARP1 La ribonucleoprotein domain family, member 1 -2.01378
ZMYM3 zinc finger, MYM-type 3 -2.01245
INTS11 integrator complex subunit 11 -2.00094