BS-181 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/49867929
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Genes

197 proteins with high or low expression in BS-181 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.72
MERTK MER proto-oncogene, tyrosine kinase 1.26
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 1.12
ZEB1 zinc finger E-box binding homeobox 1 1.03
DUOX1 dual oxidase 1 0.97
DOP1A DOP1 leucine zipper like protein A 0.95
ODC1 ornithine decarboxylase 1 0.86
WNK2 WNK lysine deficient protein kinase 2 0.81
CKM creatine kinase, muscle 0.8
F5 coagulation factor V (proaccelerin, labile factor) 0.8
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.78
NF1 neurofibromin 1 0.74
HMOX1 heme oxygenase 1 0.73
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.7
JPT1 Jupiter microtubule associated homolog 1 0.7
TSPAN3 tetraspanin 3 0.69
CPTP ceramide-1-phosphate transfer protein 0.68
CPA4 carboxypeptidase A4 0.68
PGBD2 piggyBac transposable element derived 2 0.66
PIP prolactin-induced protein 0.66
ZNF761 zinc finger protein 761 0.64
ZNF3 zinc finger protein 3 0.64
CEP85L centrosomal protein 85kDa-like 0.63
DAPK1 death-associated protein kinase 1 0.63
TPM4 tropomyosin 4 0.63
CCN3 cellular communication network factor 3 0.63
COL14A1 collagen, type XIV, alpha 1 0.63
MED8 mediator complex subunit 8 0.62
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.61
TOB1 transducer of ERBB2, 1 0.61
ZBTB12 zinc finger and BTB domain containing 12 0.6
MYL9 myosin, light chain 9, regulatory 0.59
ELOVL6 ELOVL fatty acid elongase 6 0.59
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.57
EPM2AIP1 EPM2A (laforin) interacting protein 1 0.56
PRKCH protein kinase C, eta 0.56
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0.56
AXIN2 axin 2 0.56
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.55
SH3YL1 SH3 and SYLF domain containing 1 0.55
UVRAG UV radiation resistance associated 0.55
ZNF503 zinc finger protein 503 0.55
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.55
IGFBP3 insulin-like growth factor binding protein 3 0.54
H1-0 H1.0 linker histone 0.54
DERPC DERPC proline and glycine rich nuclear protein 0.54
KCTD12 potassium channel tetramerization domain containing 12 0.54
CEP112 centrosomal protein 112kDa 0.53
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.53
AP4M1 adaptor-related protein complex 4, mu 1 subunit 0.51
TACSTD2 tumor-associated calcium signal transducer 2 0.51
CDC26 cell division cycle 26 0.51
INHBA inhibin, beta A 0.51
REEP1 receptor accessory protein 1 0.51
SPATA20 spermatogenesis associated 20 0.5
BAG3 BCL2-associated athanogene 3 0.5
KIF26A kinesin family member 26A 0.5
VTN vitronectin 0.5
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.49
RNASE4 ribonuclease, RNase A family, 4 0.48
HSPA8 heat shock 70kDa protein 8 0.48
HELQ helicase, POLQ-like 0.48
USP18 ubiquitin specific peptidase 18 0.48
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.47
BAHCC1 BAH domain and coiled-coil containing 1 0.47
MPV17L2 MPV17 mitochondrial membrane protein-like 2 0.47
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.47
NRXN3 neurexin 3 0.47
TEN1 TEN1 CST complex subunit 0.47
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.46
MARCHF7 membrane associated ring-CH-type finger 7 0.46
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.46
TMUB1 transmembrane and ubiquitin-like domain containing 1 0.46
AMPD1 adenosine monophosphate deaminase 1 0.46
GORASP1 golgi reassembly stacking protein 1, 65kDa 0.46
LIPH lipase, member H 0.45
SLC16A6 solute carrier family 16, member 6 0.45
PLAAT3 phospholipase A and acyltransferase 3 0.45
CRYM crystallin, mu 0.45
CYBA cytochrome b-245, alpha polypeptide 0.44
ZNF114 zinc finger protein 114 0.44
C18ORF32 chromosome 18 open reading frame 32 0.43
HBA1 hemoglobin, alpha 1 0.43
TANK TRAF family member-associated NFKB activator 0.43
COL6A3 collagen, type VI, alpha 3 0.43
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.43
IFRD1 interferon-related developmental regulator 1 0.43
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 0.43
ZYX zyxin 0.43
ZNF219 zinc finger protein 219 0.43
APOE apolipoprotein E 0.42
FBLIM1 filamin binding LIM protein 1 0.42
CTSL cathepsin L 0.42
F2 coagulation factor II (thrombin) 0.42
ETAA1 Ewing tumor-associated antigen 1 0.42
FKBPL FK506 binding protein like 0.42
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.42

low expression

Symbol Name Standardized Value
KMT2B lysine (K)-specific methyltransferase 2B -1.44
TOX2 TOX high mobility group box family member 2 -1.05
SLC12A8 solute carrier family 12, member 8 -0.97
MCRIP2 MAPK regulated corepressor interacting protein 2 -0.94
NME6 NME/NM23 nucleoside diphosphate kinase 6 -0.88
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -0.84
FAM160A1 family with sequence similarity 160, member A1 -0.81
ZNF362 zinc finger protein 362 -0.78
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.78
SELENOW selenoprotein W -0.77
COMMD3-BMI1 COMMD3-BMI1 readthrough -0.77
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.76
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -0.76
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 -0.74
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -0.74
ENO1 enolase 1, (alpha) -0.74
MAGEA2 melanoma antigen family A2 -0.73
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma -0.71
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -0.71
ALG8 ALG8, alpha-1,3-glucosyltransferase -0.7
CEP72 centrosomal protein 72kDa -0.69
CIAO2B cytosolic iron-sulfur assembly component 2B -0.69
PER2 period circadian clock 2 -0.67
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -0.67
FASTK Fas-activated serine/threonine kinase -0.67
MYO18B myosin XVIIIB -0.66
LGMN legumain -0.65
PRRX2 paired related homeobox 2 -0.64
FGFR4 fibroblast growth factor receptor 4 -0.64
HINT2 histidine triad nucleotide binding protein 2 -0.62
CYB5A cytochrome b5 type A (microsomal) -0.62
SLC10A4 solute carrier family 10, member 4 -0.61
ZNF692 zinc finger protein 692 -0.61
RNASEH2C ribonuclease H2, subunit C -0.61
ZNF12 zinc finger protein 12 -0.6
CETN2 centrin, EF-hand protein, 2 -0.6
VWDE von Willebrand factor D and EGF domains -0.58
BET1L Bet1 golgi vesicular membrane trafficking protein-like -0.57
TMCO3 transmembrane and coiled-coil domains 3 -0.56
TECPR1 tectonin beta-propeller repeat containing 1 -0.54
SIAH2 siah E3 ubiquitin protein ligase 2 -0.53
HEXIM2 hexamethylene bis-acetamide inducible 2 -0.53
SP100 SP100 nuclear antigen -0.52
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -0.51
COX18 COX18 cytochrome c oxidase assembly factor -0.51
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.5
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.5
ZNF518B zinc finger protein 518B -0.49
ZNF354B zinc finger protein 354B -0.49
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.49
TTC33 tetratricopeptide repeat domain 33 -0.49
CLN5 ceroid-lipofuscinosis, neuronal 5 -0.48
TSEN15 TSEN15 tRNA splicing endonuclease subunit -0.48
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -0.47
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.47
TLE2 transducin-like enhancer of split 2 -0.46
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -0.46
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.46
DDTL D-dopachrome tautomerase-like -0.45
TBC1D32 TBC1 domain family, member 32 -0.45
ELOB elongin B -0.45
CPVL carboxypeptidase, vitellogenic-like -0.45
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.44
CADPS2 Ca++-dependent secretion activator 2 -0.44
LRRC20 leucine rich repeat containing 20 -0.44
ZNF35 zinc finger protein 35 -0.44
TRAPPC6A trafficking protein particle complex 6A -0.44
COMMD3 COMM domain containing 3 -0.43
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.43
SPATA13 spermatogenesis associated 13 -0.43
TMEM231 transmembrane protein 231 -0.43
TMEM160 transmembrane protein 160 -0.43
FKTN fukutin -0.42
GINS4 GINS complex subunit 4 (Sld5 homolog) -0.42
CPD carboxypeptidase D -0.42
FBXO17 F-box protein 17 -0.42
HMGN3 high mobility group nucleosomal binding domain 3 -0.42
DDT D-dopachrome tautomerase -0.42
COPZ1 coatomer protein complex, subunit zeta 1 -0.42
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) -0.41
ASF1B anti-silencing function 1B histone chaperone -0.41
FBXO4 F-box protein 4 -0.41
GRK5 G protein-coupled receptor kinase 5 -0.41
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -0.41
CYB5D2 cytochrome b5 domain containing 2 -0.41
ACAD10 acyl-CoA dehydrogenase family, member 10 -0.41
HBB hemoglobin, beta -0.41
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -0.4
H3C1 H3 clustered histone 1 -0.4
KYAT1 kynurenine aminotransferase 1 -0.4
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase -0.4
HDAC5 histone deacetylase 5 -0.4
ADAM21 ADAM metallopeptidase domain 21 -0.4
RNF135 ring finger protein 135 -0.4
ZNF791 zinc finger protein 791 -0.39
TMEM219 transmembrane protein 219 -0.39
ZNF567 zinc finger protein 567 -0.39
RPL10 ribosomal protein L10 -0.39
TBCK TBC1 domain containing kinase -0.39
ATF6B activating transcription factor 6 beta -0.38