BTK Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description Bruton agammaglobulinemia tyrosine kinase|The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 695)
External Link http://www.ncbi.nlm.nih.gov/gene/695
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127 interacting proteins for hub protein BTK from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ACTN1 actinin, alpha 1
AFG3L2 AFG3-like AAA ATPase 2
ALDOA aldolase A, fructose-bisphosphate
AP3B1 adaptor-related protein complex 3, beta 1 subunit
ARHGAP17 Rho GTPase activating protein 17
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
BCAR1 breast cancer anti-estrogen resistance 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BLNK B-cell linker
BMX BMX non-receptor tyrosine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBX1 chromobox homolog 1
CD19 CD19 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CMTM3 CKLF-like MARVEL transmembrane domain containing 3
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBN1 drebrin 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DOK2 docking protein 2, 56kDa
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFS embryonal Fyn-associated substrate
EPOR erythropoietin receptor
EWSR1 EWS RNA-binding protein 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLNA filamin A, alpha
FTL ferritin, light polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRB2 growth factor receptor-bound protein 2
GTF2I general transcription factor IIi
H2AFZ H2A histone family, member Z
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HCK HCK proto-oncogene, Src family tyrosine kinase
HRNR hornerin
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IGF1R insulin-like growth factor 1 receptor
IGHMBP2 immunoglobulin mu binding protein 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRF2 interferon regulatory factor 2
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KCMF1 potassium channel modulatory factor 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT5 keratin 5, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LOX lysyl oxidase
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2B1 mannosidase, alpha, class 2B, member 1
MED28 mediator complex subunit 28
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MRC1 mannose receptor, C type 1
MYD88 myeloid differentiation primary response 88
MYLK2 myosin light chain kinase 2
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
PFKP phosphofructokinase, platelet
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
POTEKP POTE ankyrin domain family, member K, pseudogene
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PXN paxillin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPL7 ribosomal protein L7
RPS3 ribosomal protein S3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SFPQ splicing factor proline/glutamine-rich
SH2B2 SH2B adaptor protein 2
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SPTA1 spectrin, alpha, erythrocytic 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
SYK spleen tyrosine kinase
TEC tec protein tyrosine kinase
TICAM1 toll-like receptor adaptor molecule 1
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TP53 tumor protein p53
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
TWF1 twinfilin actin binding protein 1
VAV1 vav 1 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WASF2 WAS protein family, member 2