BTK Gene Set

Dataset Kinase Library Tyrosine Kinome Atlas
Category proteomics
Type kinase
Description Bruton agammaglobulinemia tyrosine kinase|The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 695)
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100 substrates of the kinase BTK from the Kinase Library Tyrosine Kinome Atlas dataset.

Symbol Name Standardized Value
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) 100.0
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 99.96
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 99.96
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 99.96
LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 99.91
NFYA nuclear transcription factor Y, alpha 99.82
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 99.78
TCHP trichoplein, keratin filament binding 99.76
ZNF169 zinc finger protein 169 99.72
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 99.61
UBE2E1 ubiquitin-conjugating enzyme E2E 1 99.56
UBE2E2 ubiquitin-conjugating enzyme E2E 2 99.56
UBE2E3 ubiquitin-conjugating enzyme E2E 3 99.56
FHOD1 formin homology 2 domain containing 1 99.37
UBA7 ubiquitin-like modifier activating enzyme 7 99.25
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 99.17
GMPPA GDP-mannose pyrophosphorylase A 99.15
PTPRB protein tyrosine phosphatase, receptor type, B 99.12
CKS2 CDC28 protein kinase regulatory subunit 2 99.08
TWF1 twinfilin actin binding protein 1 98.84
N4BP2 NEDD4 binding protein 2 98.77
ANKZF1 ankyrin repeat and zinc finger domain containing 1 98.71
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 98.58
VCP valosin containing protein 98.56
R3HCC1L R3H domain and coiled-coil containing 1-like 98.55
ZCCHC3 zinc finger, CCHC domain containing 3 98.53
SMG8 SMG8 nonsense mediated mRNA decay factor 98.51
RPS29 ribosomal protein S29 98.47
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 98.45
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 98.45
COG3 component of oligomeric golgi complex 3 98.43
MTOR mechanistic target of rapamycin (serine/threonine kinase) 98.36
RDX radixin 98.34
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 98.27
RABGAP1L RAB GTPase activating protein 1-like 98.25
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 98.23
CSNK2A2 casein kinase 2, alpha prime polypeptide 98.21
MUC16 mucin 16, cell surface associated 98.18
DPH6 diphthamine biosynthesis 6 98.12
RPL36AL ribosomal protein L36a-like 98.05
AP1AR adaptor-related protein complex 1 associated regulatory protein 97.97
TCF25 transcription factor 25 (basic helix-loop-helix) 97.94
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 97.86
PTPRH protein tyrosine phosphatase, receptor type, H 97.85
GEMIN8 gem (nuclear organelle) associated protein 8 97.81
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 97.75
CKAP4 cytoskeleton-associated protein 4 97.5
HAVCR1 hepatitis A virus cellular receptor 1 97.46
PRMT3 protein arginine methyltransferase 3 97.44
FDFT1 farnesyl-diphosphate farnesyltransferase 1 97.42
BCAS2 breast carcinoma amplified sequence 2 97.35
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 97.33
OR8B4 olfactory receptor, family 8, subfamily B, member 4 (gene/pseudogene) 97.26
CHD2 chromodomain helicase DNA binding protein 2 97.24
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 97.18
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 97.16
EGR1 early growth response 1 97.15
DOK3 docking protein 3 97.09
GIMAP4 GTPase, IMAP family member 4 97.07
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 97.05
THRB thyroid hormone receptor, beta 97.05
ELP3 elongator acetyltransferase complex subunit 3 97.045
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 97.02
CEP55 centrosomal protein 55kDa 96.94
FBXO9 F-box protein 9 96.91
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 96.89
TEX2 testis expressed 2 96.85
SMC4 structural maintenance of chromosomes 4 96.78
SH3GLB2 SH3-domain GRB2-like endophilin B2 96.74
RBM25 RNA binding motif protein 25 96.61
PBX2 pre-B-cell leukemia homeobox 2 96.59
GCHFR GTP cyclohydrolase I feedback regulator 96.56
TWF2 twinfilin actin binding protein 2 96.5
MCRIP1 MAPK regulated corepressor interacting protein 1 96.35
FHIT fragile histidine triad 96.28
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 96.28
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 96.27
CNOT9 CCR4-NOT transcription complex subunit 9 96.21
MKI67 marker of proliferation Ki-67 96.205
RIOK1 RIO kinase 1 96.17
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 96.13
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 96.0
RAB34 RAB34, member RAS oncogene family 95.97
GDI1 GDP dissociation inhibitor 1 95.88
NUMA1 nuclear mitotic apparatus protein 1 95.8
AHCY adenosylhomocysteinase 95.75
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 95.73
TGFB1I1 transforming growth factor beta 1 induced transcript 1 95.69
ANXA6 annexin A6 95.58
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 95.56
RPS16 ribosomal protein S16 95.51
SIPA1L1 signal-induced proliferation-associated 1 like 1 95.49
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 95.45
ANKRD26 ankyrin repeat domain 26 95.38
CHERP calcium homeostasis endoplasmic reticulum protein 95.275
FCRL6 Fc receptor-like 6 95.27
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 95.25
CEP89 centrosomal protein 89kDa 95.19
PCYOX1 prenylcysteine oxidase 1 95.16
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 95.08