BTK_mutant_1_GDS1346 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS1346
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Genes

600 genes differentially expressed following the BTK_mutant_1_GDS1346 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
OPN1LW opsin 1 (cone pigments), long-wave-sensitive 2.69361
TGM2 transglutaminase 2 2.68638
MFAP2 microfibrillar-associated protein 2 2.24046
XPR1 xenotropic and polytropic retrovirus receptor 1 2.11267
UBQLN2 ubiquilin 2 2.04105
COMT catechol-O-methyltransferase 2.00402
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 1.94514
HOXD3 homeobox D3 1.78619
YIPF5 Yip1 domain family, member 5 1.57495
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 1.52216
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1.42726
LYPD8 LY6/PLAUR domain containing 8 1.3352
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 1.17659
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 1.142
GSTM5 glutathione S-transferase mu 5 0.9895
C8G complement component 8, gamma polypeptide 0.987776
RLIM ring finger protein, LIM domain interacting 0.936905
NAT6 N-acetyltransferase 6 (GCN5-related) 0.929908
ANKRD49 ankyrin repeat domain 49 0.889481
ANXA4 annexin A4 0.889328
PRKCD protein kinase C, delta 0.863412
CDK9 cyclin-dependent kinase 9 0.845638
CPSF3L cleavage and polyadenylation specific factor 3-like 0.798701
MMP8 matrix metallopeptidase 8 0.748884
MED1 mediator complex subunit 1 0.739304
LBR lamin B receptor 0.721338
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.708985
SKAP2 src kinase associated phosphoprotein 2 0.699601
DHH desert hedgehog 0.681551
MCAM melanoma cell adhesion molecule 0.668404
MINOS1 mitochondrial inner membrane organizing system 1 0.657856
PCSK4 proprotein convertase subtilisin/kexin type 4 0.656547
BROX BRO1 domain and CAAX motif containing 0.649126
COPS8 COP9 signalosome subunit 8 0.648271
RAB5C RAB5C, member RAS oncogene family 0.640696
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.640577
SEPT9 septin 9 0.623319
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.621239
STXBP2 syntaxin binding protein 2 0.604737
GDF15 growth differentiation factor 15 0.603441
DPF3 D4, zinc and double PHD fingers, family 3 0.602869
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 0.562776
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.551142
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.549906
PPOX protoporphyrinogen oxidase 0.542616
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.513067
DSCR3 Down syndrome critical region 3 0.512619
IFNGR1 interferon gamma receptor 1 0.50184
INO80E INO80 complex subunit E 0.496155
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.495043
PDAP1 PDGFA associated protein 1 0.489059
KLF13 Kruppel-like factor 13 0.487519
KLF12 Kruppel-like factor 12 0.480995
TSC2 tuberous sclerosis 2 0.479806
PITX3 paired-like homeodomain 3 0.472191
ZSWIM7 zinc finger, SWIM-type containing 7 0.466834
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.463695
PER2 period circadian clock 2 0.455102
WBP1L WW domain binding protein 1-like 0.453671
LONP1 lon peptidase 1, mitochondrial 0.444529
COL5A1 collagen, type V, alpha 1 0.442011
RAP2B RAP2B, member of RAS oncogene family 0.438853
SEC14L1 SEC14-like 1 (S. cerevisiae) 0.426064
TLX2 T-cell leukemia homeobox 2 0.423991
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.423643
GRPEL2 GrpE-like 2, mitochondrial (E. coli) 0.420476
MSL2 male-specific lethal 2 homolog (Drosophila) 0.419771
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.41709
PADI1 peptidyl arginine deiminase, type I 0.41704
ITM2C integral membrane protein 2C 0.413702
C1ORF86 chromosome 1 open reading frame 86 0.412971
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.410182
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.405302
ADGRE5 adhesion G protein-coupled receptor E5 0.404221
ACVRL1 activin A receptor type II-like 1 0.401362
TBXAS1 thromboxane A synthase 1 (platelet) 0.399151
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.39907
C2 complement component 2 0.397656
UBXN1 UBX domain protein 1 0.393887
COL1A2 collagen, type I, alpha 2 0.393773
C17ORF62 chromosome 17 open reading frame 62 0.39218
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 0.377698
C9ORF40 chromosome 9 open reading frame 40 0.369728
MEF2D myocyte enhancer factor 2D 0.363518
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.354754
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 0.346575
XCR1 chemokine (C motif) receptor 1 0.346266
PARK7 parkinson protein 7 0.340788
CMTR1 cap methyltransferase 1 0.339532
VLDLR very low density lipoprotein receptor 0.334248
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.333062
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.331522
UBA7 ubiquitin-like modifier activating enzyme 7 0.32396
RAB9A RAB9A, member RAS oncogene family 0.322815
CA5A carbonic anhydrase VA, mitochondrial 0.321434
NTN1 netrin 1 0.319836
RSAD2 radical S-adenosyl methionine domain containing 2 0.318477
CACHD1 cache domain containing 1 0.315173
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.314598
ITGB4 integrin, beta 4 0.314523
IRF8 interferon regulatory factor 8 0.314375
TMEM5 transmembrane protein 5 0.313477
ZNF706 zinc finger protein 706 0.312137
SUMO3 small ubiquitin-like modifier 3 0.309218
PKP4 plakophilin 4 0.309179
NKAIN1 Na+/K+ transporting ATPase interacting 1 0.308782
FAM110A family with sequence similarity 110, member A 0.306088
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.300771
SRP68 signal recognition particle 68kDa 0.300648
SPATA6 spermatogenesis associated 6 0.291944
GPR50 G protein-coupled receptor 50 0.287597
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 0.287078
SIT1 signaling threshold regulating transmembrane adaptor 1 0.282764
PARP8 poly (ADP-ribose) polymerase family, member 8 0.279493
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 0.274108
MBP myelin basic protein 0.273893
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.268723
CMIP c-Maf inducing protein 0.268629
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.268552
S100A13 S100 calcium binding protein A13 0.267004
LAMA1 laminin, alpha 1 0.265426
USP12 ubiquitin specific peptidase 12 0.264684
LAPTM4B lysosomal protein transmembrane 4 beta 0.261149
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.26049
SMAD1 SMAD family member 1 0.26025
THUMPD1 THUMP domain containing 1 0.258874
STX7 syntaxin 7 0.258503
DGCR14 DiGeorge syndrome critical region gene 14 0.25659
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.255797
SLC35E1 solute carrier family 35, member E1 0.252544
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.252441
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 0.252301
IGFBP7 insulin-like growth factor binding protein 7 0.251503
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.245656
SPTSSA serine palmitoyltransferase, small subunit A 0.245225
FZD3 frizzled class receptor 3 0.2428
FAM189B family with sequence similarity 189, member B 0.242769
TMEM37 transmembrane protein 37 0.242763
LEFTY1 left-right determination factor 1 0.24272
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 0.242717
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.242057
EI24 etoposide induced 2.4 0.241522
PRNP prion protein 0.241519
HFE hemochromatosis 0.241208
LGALS4 lectin, galactoside-binding, soluble, 4 0.238828
NCF2 neutrophil cytosolic factor 2 0.237741
MCUR1 mitochondrial calcium uniporter regulator 1 0.235003
IVD isovaleryl-CoA dehydrogenase 0.233637
GP5 glycoprotein V (platelet) 0.230963
YME1L1 YME1-like 1 ATPase 0.228878
VPREB1 pre-B lymphocyte 1 0.22793
AVP arginine vasopressin 0.227727
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.227536
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.225497
BASP1 brain abundant, membrane attached signal protein 1 0.222257
PIH1D1 PIH1 domain containing 1 0.221772
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 0.221263
JMJD6 jumonji domain containing 6 0.220396
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 0.219411
TUBB6 tubulin, beta 6 class V 0.21941
FABP4 fatty acid binding protein 4, adipocyte 0.218575
ATAD1 ATPase family, AAA domain containing 1 0.21787
OSER1 oxidative stress responsive serine-rich 1 0.217208
TNNC1 troponin C type 1 (slow) 0.215755
CCDC28B coiled-coil domain containing 28B 0.215754
FIBP fibroblast growth factor (acidic) intracellular binding protein 0.214608
FHDC1 FH2 domain containing 1 0.214448
MATN2 matrilin 2 0.213937
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.213708
NMB neuromedin B 0.213331
HMGB4 high mobility group box 4 0.211544
CNN3 calponin 3, acidic 0.208746
FXYD3 FXYD domain containing ion transport regulator 3 0.208548
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.206859
PQLC3 PQ loop repeat containing 3 0.206362
C11ORF54 chromosome 11 open reading frame 54 0.206204
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 0.204599
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.204522
POLR1D polymerase (RNA) I polypeptide D, 16kDa 0.20418
DCN decorin 0.203684
SLC22A23 solute carrier family 22, member 23 0.2027
IFNA4 interferon, alpha 4 0.202608
DRC1 dynein regulatory complex subunit 1 0.201679
GLIPR2 GLI pathogenesis-related 2 0.201638
NPDC1 neural proliferation, differentiation and control, 1 0.201112
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.200388
IPO11 importin 11 0.199313
SMC3 structural maintenance of chromosomes 3 0.199256
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.198296
SURF6 surfeit 6 0.197922
WNK2 WNK lysine deficient protein kinase 2 0.197808
CCBL2 cysteine conjugate-beta lyase 2 0.196832
FLOT1 flotillin 1 0.196413
ALOX15B arachidonate 15-lipoxygenase, type B 0.195408
FAM136A family with sequence similarity 136, member A 0.194297
ERCC1 excision repair cross-complementation group 1 0.19416
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.19404
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.193847
TCF12 transcription factor 12 0.19384
ECT2 epithelial cell transforming 2 0.193739
MTCH1 mitochondrial carrier 1 0.193237
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 0.192631
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) 0.189775
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 0.188645
SMIM7 small integral membrane protein 7 0.188216
CD93 CD93 molecule 0.187655
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.187401
SETD8 SET domain containing (lysine methyltransferase) 8 0.185973
PTPRO protein tyrosine phosphatase, receptor type, O 0.185565
PEPD peptidase D 0.185325
SOCS2 suppressor of cytokine signaling 2 0.184507
NRTN neurturin 0.18423
NDFIP1 Nedd4 family interacting protein 1 0.183551
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.183327
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.183251
CTSA cathepsin A 0.183049
FAM84A family with sequence similarity 84, member A 0.181991
TXK TXK tyrosine kinase 0.181122
ZNF467 zinc finger protein 467 0.17915
ITK IL2-inducible T-cell kinase 0.178768
NECAP1 NECAP endocytosis associated 1 0.176598
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.175413
LIFR leukemia inhibitory factor receptor alpha 0.175376
HP1BP3 heterochromatin protein 1, binding protein 3 0.174092
CANT1 calcium activated nucleotidase 1 0.172203
ITM2B integral membrane protein 2B 0.171175
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.170926
DMTF1 cyclin D binding myb-like transcription factor 1 0.170417
UGP2 UDP-glucose pyrophosphorylase 2 0.169898
TMEM59 transmembrane protein 59 0.169221
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F 0.168774
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 0.168193
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.168021
MRC2 mannose receptor, C type 2 0.167647
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 0.165238
BDNF brain-derived neurotrophic factor 0.164157
PEX11B peroxisomal biogenesis factor 11 beta 0.163758
DDA1 DET1 and DDB1 associated 1 0.163753
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.163562
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.162489
ASCL1 achaete-scute family bHLH transcription factor 1 0.161246
CLRN3 clarin 3 0.161175
IL12RB2 interleukin 12 receptor, beta 2 0.160653
WAC WW domain containing adaptor with coiled-coil 0.158045
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 0.157906
ADAMDEC1 ADAM-like, decysin 1 0.156371
CGA glycoprotein hormones, alpha polypeptide 0.156318
SRSF2 serine/arginine-rich splicing factor 2 0.156147
MCFD2 multiple coagulation factor deficiency 2 0.155448
ITGB7 integrin, beta 7 0.154362
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.154313
APC adenomatous polyposis coli 0.152951
IGF1R insulin-like growth factor 1 receptor 0.151206
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 0.151182
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.147711
MFGE8 milk fat globule-EGF factor 8 protein 0.147037
SPRED2 sprouty-related, EVH1 domain containing 2 0.146681
WDR13 WD repeat domain 13 0.146558
DAPK2 death-associated protein kinase 2 0.145784
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.145036
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.144625
ANXA5 annexin A5 0.143698
NELFA negative elongation factor complex member A 0.143384
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.14289
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.14268
TSHB thyroid stimulating hormone, beta 0.142671
RASA4 RAS p21 protein activator 4 0.142326
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.142313
NMT1 N-myristoyltransferase 1 0.141598
BCAS3 breast carcinoma amplified sequence 3 0.140689
BRD7 bromodomain containing 7 0.137751
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 0.137378
SSTR1 somatostatin receptor 1 0.136804
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.136486
KIF2A kinesin heavy chain member 2A 0.135776
PPA2 pyrophosphatase (inorganic) 2 0.135625
SBF2 SET binding factor 2 0.13538
USP2 ubiquitin specific peptidase 2 0.135355
ZNF598 zinc finger protein 598 0.135148
ASGR1 asialoglycoprotein receptor 1 0.135038
CCNC cyclin C 0.134237
CORO1C coronin, actin binding protein, 1C 0.133487
SNX17 sorting nexin 17 0.133318
DCTN3 dynactin 3 (p22) 0.132953
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 0.132154
C6ORF106 chromosome 6 open reading frame 106 0.132119
TMX1 thioredoxin-related transmembrane protein 1 0.131659
ADRB1 adrenoceptor beta 1 0.129642
SHF Src homology 2 domain containing F 0.129509
TBC1D23 TBC1 domain family, member 23 0.129281
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 0.129237
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1 0.128883
TEX261 testis expressed 261 0.127867
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 0.127178
HIST1H2BO histone cluster 1, H2bo 0.12684
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.126635
PTPRC protein tyrosine phosphatase, receptor type, C 0.126451
HAL histidine ammonia-lyase 0.126074
COL19A1 collagen, type XIX, alpha 1 0.126009
ZFHX4 zinc finger homeobox 4 0.125878

decreased expression

Symbol Name Standardized Value
EXT2 exostosin glycosyltransferase 2 -6.13913
TPST1 tyrosylprotein sulfotransferase 1 -2.69469
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.62101
BTF3L4 basic transcription factor 3-like 4 -2.23658
LSM1 LSM1, U6 small nuclear RNA associated -1.95768
BTD biotinidase -1.82437
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -1.64749
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -1.36447
SPAG7 sperm associated antigen 7 -1.32933
CDC45 cell division cycle 45 -1.23092
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase -1.20873
TAPBP TAP binding protein (tapasin) -1.17087
AURKAIP1 aurora kinase A interacting protein 1 -1.07008
CAB39L calcium binding protein 39-like -1.0263
GIMAP4 GTPase, IMAP family member 4 -0.94954
GCSH glycine cleavage system protein H (aminomethyl carrier) -0.945772
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa -0.907333
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -0.901545
AKT2 v-akt murine thymoma viral oncogene homolog 2 -0.891039
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 -0.879996
FOXD1 forkhead box D1 -0.858674
FAM102A family with sequence similarity 102, member A -0.815658
TFDP1 transcription factor Dp-1 -0.792371
CD38 CD38 molecule -0.78639
TRIM11 tripartite motif containing 11 -0.755975
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase -0.744795
IFI30 interferon, gamma-inducible protein 30 -0.672171
RGCC regulator of cell cycle -0.649052
ANTXR2 anthrax toxin receptor 2 -0.616502
C9ORF78 chromosome 9 open reading frame 78 -0.605401
EGF epidermal growth factor -0.580208
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.574219
CCT7 chaperonin containing TCP1, subunit 7 (eta) -0.571493
MCOLN2 mucolipin 2 -0.566457
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.565088
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -0.553436
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -0.542491
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.523684
LMO7 LIM domain 7 -0.50334
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -0.492867
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.48891
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.483457
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -0.473757
GTF2A1 general transcription factor IIA, 1, 19/37kDa -0.472079
EGFL8 EGF-like-domain, multiple 8 -0.470196
KIF4A kinesin family member 4A -0.460405
ADRM1 adhesion regulating molecule 1 -0.447114
RECQL5 RecQ protein-like 5 -0.439503
CYTH2 cytohesin 2 -0.438248
GPALPP1 GPALPP motifs containing 1 -0.435188
CRMP1 collapsin response mediator protein 1 -0.433881
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -0.433385
OSTC oligosaccharyltransferase complex subunit (non-catalytic) -0.431904
GGCT gamma-glutamylcyclotransferase -0.427468
FABP1 fatty acid binding protein 1, liver -0.421613
CDCA8 cell division cycle associated 8 -0.415966
FAM96A family with sequence similarity 96, member A -0.404492
BDKRB2 bradykinin receptor B2 -0.40318
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.402772
NVL nuclear VCP-like -0.402545
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -0.399385
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.399068
ZNF639 zinc finger protein 639 -0.393403
MCM4 minichromosome maintenance complex component 4 -0.38003
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -0.376891
AAAS achalasia, adrenocortical insufficiency, alacrimia -0.372657
COMMD2 COMM domain containing 2 -0.371661
RAD50 RAD50 homolog (S. cerevisiae) -0.370066
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha -0.364287
TOP3B topoisomerase (DNA) III beta -0.354084
AQR aquarius intron-binding spliceosomal factor -0.350953
SRI sorcin -0.34127
SARS2 seryl-tRNA synthetase 2, mitochondrial -0.339392
CBX1 chromobox homolog 1 -0.333951
PDIA6 protein disulfide isomerase family A, member 6 -0.332285
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.329901
CDC20 cell division cycle 20 -0.329493
ANAPC13 anaphase promoting complex subunit 13 -0.325785
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit -0.325588
USP34 ubiquitin specific peptidase 34 -0.323145
DCTN1 dynactin 1 -0.320641
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -0.319523
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.319238
GRPR gastrin-releasing peptide receptor -0.317447
MARS methionyl-tRNA synthetase -0.315059
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -0.312466
AKAP1 A kinase (PRKA) anchor protein 1 -0.312005
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -0.310975
LYPLA1 lysophospholipase I -0.309639
RUNDC3A RUN domain containing 3A -0.307689
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.303078
DBNL drebrin-like -0.30306
RASAL1 RAS protein activator like 1 (GAP1 like) -0.300164
IL11 interleukin 11 -0.298174
F2RL2 coagulation factor II (thrombin) receptor-like 2 -0.296666
PDLIM7 PDZ and LIM domain 7 (enigma) -0.29471
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.293197
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.291426
TM2D3 TM2 domain containing 3 -0.291317
STARD10 StAR-related lipid transfer (START) domain containing 10 -0.288977
ODF2L outer dense fiber of sperm tails 2-like -0.287552
SRPK3 SRSF protein kinase 3 -0.287283
CXXC1 CXXC finger protein 1 -0.284029
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.281685
IRF2BP1 interferon regulatory factor 2 binding protein 1 -0.279239
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.275203
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -0.273886
SLU7 SLU7 splicing factor homolog (S. cerevisiae) -0.260195
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.258006
SULT1C3 sulfotransferase family, cytosolic, 1C, member 3 -0.255997
TSPAN3 tetraspanin 3 -0.253403
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -0.253161
TCF4 transcription factor 4 -0.253031
SND1 staphylococcal nuclease and tudor domain containing 1 -0.247396
CASP3 caspase 3, apoptosis-related cysteine peptidase -0.241283
RPUSD4 RNA pseudouridylate synthase domain containing 4 -0.238988
CDKN2AIPNL CDKN2A interacting protein N-terminal like -0.237852
UBA5 ubiquitin-like modifier activating enzyme 5 -0.237297
IKZF4 IKAROS family zinc finger 4 (Eos) -0.236481
FEN1 flap structure-specific endonuclease 1 -0.233949
ANGEL2 angel homolog 2 (Drosophila) -0.233148
DDB1 damage-specific DNA binding protein 1, 127kDa -0.231656
C9ORF72 chromosome 9 open reading frame 72 -0.230689
YPEL3 yippee-like 3 (Drosophila) -0.229825
HPS1 Hermansky-Pudlak syndrome 1 -0.228907
MRPL42 mitochondrial ribosomal protein L42 -0.226037
EMC3 ER membrane protein complex subunit 3 -0.225921
MED27 mediator complex subunit 27 -0.224351
REXO2 RNA exonuclease 2 -0.223241
PACRGL PARK2 co-regulated-like -0.22263
RNF181 ring finger protein 181 -0.219704
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.218694
MXD4 MAX dimerization protein 4 -0.218436
TEN1 TEN1 CST complex subunit -0.217317
COASY CoA synthase -0.216701
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.215981
CD22 CD22 molecule -0.212645
GFER growth factor, augmenter of liver regeneration -0.20849
PGAM1 phosphoglycerate mutase 1 (brain) -0.205922
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.205766
LTA4H leukotriene A4 hydrolase -0.203804
PRM3 protamine 3 -0.203745
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -0.203317
IFT20 intraflagellar transport 20 -0.201324
CDK16 cyclin-dependent kinase 16 -0.199712
MAPK12 mitogen-activated protein kinase 12 -0.198856
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -0.197497
HELLS helicase, lymphoid-specific -0.197321
NDNL2 necdin-like 2 -0.197006
NR0B2 nuclear receptor subfamily 0, group B, member 2 -0.195424
GNS glucosamine (N-acetyl)-6-sulfatase -0.195152
B3GAT3 beta-1,3-glucuronyltransferase 3 -0.194208
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 -0.193665
PXMP2 peroxisomal membrane protein 2, 22kDa -0.193083
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -0.192309
MRPL49 mitochondrial ribosomal protein L49 -0.192294
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.191337
STRADA STE20-related kinase adaptor alpha -0.190919
NLRX1 NLR family member X1 -0.190053
MYH7 myosin, heavy chain 7, cardiac muscle, beta -0.189875
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -0.188292
BCAP31 B-cell receptor-associated protein 31 -0.187167
SESN1 sestrin 1 -0.185096
NIN ninein (GSK3B interacting protein) -0.184244
MEF2C myocyte enhancer factor 2C -0.182655
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit -0.182286
DAXX death-domain associated protein -0.182141
RORA RAR-related orphan receptor A -0.181962
NDE1 nudE neurodevelopment protein 1 -0.181319
GLRX3 glutaredoxin 3 -0.181144
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -0.180918
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -0.180727
RNASEH2B ribonuclease H2, subunit B -0.180527
SOWAHC sosondowah ankyrin repeat domain family member C -0.18045
NMD3 NMD3 ribosome export adaptor -0.180439
UGDH UDP-glucose 6-dehydrogenase -0.180121
PPP1R7 protein phosphatase 1, regulatory subunit 7 -0.179401
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.176118
NOTCH4 notch 4 -0.174712
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.174151
YIPF4 Yip1 domain family, member 4 -0.17361
MDP1 magnesium-dependent phosphatase 1 -0.173537
CDK2 cyclin-dependent kinase 2 -0.171922
MYO1E myosin IE -0.168356
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.167793
UFD1L ubiquitin fusion degradation 1 like (yeast) -0.167033
SNX2 sorting nexin 2 -0.166073
SMAGP small cell adhesion glycoprotein -0.164302
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) -0.163877
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.163743
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.162517
IARS isoleucyl-tRNA synthetase -0.159078
SAP30L SAP30-like -0.157484
MTF2 metal response element binding transcription factor 2 -0.155936
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -0.155073
SNX1 sorting nexin 1 -0.153907
USP25 ubiquitin specific peptidase 25 -0.153212
SLMO2 slowmo homolog 2 (Drosophila) -0.152612
METTL1 methyltransferase like 1 -0.150728
ADD1 adducin 1 (alpha) -0.149754
RTTN rotatin -0.148266
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 -0.146525
MRPL43 mitochondrial ribosomal protein L43 -0.14647
E2F8 E2F transcription factor 8 -0.146441
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.144849
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.143347
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -0.142981
BTF3 basic transcription factor 3 -0.142035
NUP93 nucleoporin 93kDa -0.141589
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.140518
FCHO1 FCH domain only 1 -0.140015
PNMT phenylethanolamine N-methyltransferase -0.138904
CSDE1 cold shock domain containing E1, RNA-binding -0.138764
UNC119B unc-119 homolog B (C. elegans) -0.138469
PHTF2 putative homeodomain transcription factor 2 -0.138299
CDH9 cadherin 9, type 2 (T1-cadherin) -0.137717
MRFAP1 Morf4 family associated protein 1 -0.137364
SLC25A44 solute carrier family 25, member 44 -0.134121
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.132703
C5ORF34 chromosome 5 open reading frame 34 -0.132255
ZC3H3 zinc finger CCCH-type containing 3 -0.130776
ZFR zinc finger RNA binding protein -0.130743
SEPT11 septin 11 -0.129265
MRPL34 mitochondrial ribosomal protein L34 -0.128444
ATP7A ATPase, Cu++ transporting, alpha polypeptide -0.128443
PPP1R3C protein phosphatase 1, regulatory subunit 3C -0.128406
SLMAP sarcolemma associated protein -0.128108
RPL21 ribosomal protein L21 -0.127835
FAM13B family with sequence similarity 13, member B -0.127173
PDCD2 programmed cell death 2 -0.127052
PHF1 PHD finger protein 1 -0.125842
HINT2 histidine triad nucleotide binding protein 2 -0.125724
GTPBP2 GTP binding protein 2 -0.125226
G6PC3 glucose 6 phosphatase, catalytic, 3 -0.124759
BCL2 B-cell CLL/lymphoma 2 -0.124503
LY6E lymphocyte antigen 6 complex, locus E -0.124483
RENBP renin binding protein -0.124256
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.123995
TRAF3IP2 TRAF3 interacting protein 2 -0.123403
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 -0.121531
ZBTB48 zinc finger and BTB domain containing 48 -0.121504
HSPB2 heat shock 27kDa protein 2 -0.121497
MROH1 maestro heat-like repeat family member 1 -0.121467
MAP1B microtubule-associated protein 1B -0.120376
MTIF2 mitochondrial translational initiation factor 2 -0.120226
FKBP7 FK506 binding protein 7 -0.120214
PIGS phosphatidylinositol glycan anchor biosynthesis, class S -0.11956
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.119277
MOB2 MOB kinase activator 2 -0.117896
LRP5 low density lipoprotein receptor-related protein 5 -0.117389
TRAPPC1 trafficking protein particle complex 1 -0.11726
METTL17 methyltransferase like 17 -0.116602
DCTN5 dynactin 5 (p25) -0.116465
GGPS1 geranylgeranyl diphosphate synthase 1 -0.116231
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -0.115923
TMPO thymopoietin -0.115582
BCL6 B-cell CLL/lymphoma 6 -0.11531
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -0.115073
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.114367
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -0.113522
HIP1R huntingtin interacting protein 1 related -0.113368
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.112953
CDC23 cell division cycle 23 -0.112694
PTS 6-pyruvoyltetrahydropterin synthase -0.112662
NEO1 neogenin 1 -0.112482
NT5DC3 5'-nucleotidase domain containing 3 -0.11222
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.111862
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 -0.111595
BIN1 bridging integrator 1 -0.111376
CALB2 calbindin 2 -0.109951
PDE7A phosphodiesterase 7A -0.109611
SDHAF1 succinate dehydrogenase complex assembly factor 1 -0.10854
NFYC nuclear transcription factor Y, gamma -0.10828
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide -0.107909
SMTN smoothelin -0.107668
PER3 period circadian clock 3 -0.106975
PPA1 pyrophosphatase (inorganic) 1 -0.106892
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.10659
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.10628
DGKA diacylglycerol kinase, alpha 80kDa -0.105934
MTCH2 mitochondrial carrier 2 -0.105459
METTL18 methyltransferase like 18 -0.105068
EXOC7 exocyst complex component 7 -0.104839
NEK7 NIMA-related kinase 7 -0.104549
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.104482
CCR1 chemokine (C-C motif) receptor 1 -0.103608
ADCY7 adenylate cyclase 7 -0.103427
GIMAP1 GTPase, IMAP family member 1 -0.103223
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -0.101222
TMEM214 transmembrane protein 214 -0.100998
CUL3 cullin 3 -0.100782
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein -0.100772
POU6F1 POU class 6 homeobox 1 -0.10055
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.099248
PTPRA protein tyrosine phosphatase, receptor type, A -0.098773
AOC1 amine oxidase, copper containing 1 -0.098729
ARAF A-Raf proto-oncogene, serine/threonine kinase -0.098557
GANAB glucosidase, alpha; neutral AB -0.097682
WNT10A wingless-type MMTV integration site family, member 10A -0.096387
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 -0.096113