BTRC Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description beta-transducin repeat containing E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 8945)
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Genes

308 genes differentially expressed following the BTRC gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.51194
SQOR sulfide quinone oxidoreductase 3.51194
TMEM31 transmembrane protein 31 3.51194
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.51194
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 3.51194
RP1 retinitis pigmentosa 1 (autosomal dominant) 3.51194
TACSTD2 tumor-associated calcium signal transducer 2 3.51194
PAPOLB poly(A) polymerase beta (testis specific) 3.51194
HAPLN1 hyaluronan and proteoglycan link protein 1 3.51194
BTNL8 butyrophilin-like 8 3.51194
PTH2 parathyroid hormone 2 3.51194
C1QL3 complement component 1, q subcomponent-like 3 3.51194
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.51194
CAPSL calcyphosine-like 3.51194
C11ORF16 chromosome 11 open reading frame 16 3.51194
COL20A1 collagen, type XX, alpha 1 3.51194
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 3.51194
NPY neuropeptide Y 3.51194
NRSN1 neurensin 1 3.51194
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.51194
ZC2HC1B zinc finger, C2HC-type containing 1B 3.51194
GPR150 G protein-coupled receptor 150 3.51194
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.51194
PDIA2 protein disulfide isomerase family A, member 2 3.44794
ZNF99 zinc finger protein 99 3.44794
MEP1A meprin A, alpha (PABA peptide hydrolase) 3.44794
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 3.44794
GJB2 gap junction protein, beta 2, 26kDa 3.44794
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.44794
PGBDF plakoglobin binding and degradation factor 3.44794
UNC13C unc-13 homolog C (C. elegans) 3.44794
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.44794
CDH5 cadherin 5, type 2 (vascular endothelium) 3.44794
TRIM10 tripartite motif containing 10 3.44794
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.44794
HMX3 H6 family homeobox 3 3.44794
CPLX3 complexin 3 3.44794
MUC20 mucin 20, cell surface associated 3.44794
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.44794
TCP11 t-complex 11, testis-specific 3.44794
TRIM42 tripartite motif containing 42 3.44794
CLEC5A C-type lectin domain family 5, member A 3.44794
TTLL2 tubulin tyrosine ligase-like family member 2 3.44794
TMEM217 transmembrane protein 217 3.44794
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 3.44794
SP7 Sp7 transcription factor 3.44794
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.44794
OPRL1 opiate receptor-like 1 3.44794
GDNF glial cell derived neurotrophic factor 3.44794
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 3.44794
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.44794
CD69 CD69 molecule 3.44794
ETV2 ets variant 2 3.44794
FPR2 formyl peptide receptor 2 3.44794
ACTL8 actin-like 8 3.44794
WNT16 wingless-type MMTV integration site family, member 16 3.44794
TMPRSS6 transmembrane protease, serine 6 3.44794
CIROZ ciliated left-right organizer protein containing ZP-N domains 3.44794
OR6F1 olfactory receptor, family 6, subfamily F, member 1 3.44794
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.44794
VN1R2 vomeronasal 1 receptor 2 3.44794
CCDC198 coiled-coil domain containing 198 3.44794
TBXT T-box transcription factor T 3.44794
PLPP4 phospholipid phosphatase 4 3.44794
JAML junction adhesion molecule like 3.44794
TMEM273 transmembrane protein 273 3.44794
ODAPH odontogenesis associated phosphoprotein 3.44794
SEPTIN12 septin 12 3.44794
H3C3 H3 clustered histone 3 3.44794
RHEX regulator of hemoglobinization and erythroid cell expansion 3.44794
IRF2-DT IRF2 divergent transcript 3.44794
LY6S-AS1 LY6S antisense RNA 1 3.44794
DYNLRB2 dynein, light chain, roadblock-type 2 3.44794
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 3.44794
MLANA melan-A 3.44794
ACOT4 acyl-CoA thioesterase 4 3.44794
PCDHA6 protocadherin alpha 6 3.44794
RHOXF2 Rhox homeobox family, member 2 3.44794
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.44794
CCDC17 coiled-coil domain containing 17 3.44794
ANKRD40CL ANKRD40 C-terminal like 3.44794
BBS5 Bardet-Biedl syndrome 5 3.44794
CALCA calcitonin-related polypeptide alpha 3.44794
CATSPERD catsper channel auxiliary subunit delta 3.44794
HAPLN2 hyaluronan and proteoglycan link protein 2 3.44794
TPTE transmembrane phosphatase with tensin homology 3.44794
C1QL2 complement component 1, q subcomponent-like 2 3.44794
FGFBP1 fibroblast growth factor binding protein 1 3.44794
LRRC72 leucine rich repeat containing 72 3.44794
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.44794
CCDC42 coiled-coil domain containing 42 3.44794
CSAG2 CSAG family, member 2 3.44794
TBC1D3I TBC1 domain family member 3I 3.44794
NMUR2 neuromedin U receptor 2 3.44794
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.44794
OR8H2 olfactory receptor, family 8, subfamily H, member 2 3.44794
SLITRK6 SLIT and NTRK-like family, member 6 3.44794
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 3.44794
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 3.44794
VTCN1 V-set domain containing T cell activation inhibitor 1 3.44794
CRYBA1 crystallin, beta A1 3.44794
CHRM4 cholinergic receptor, muscarinic 4 3.44794
GFRAL GDNF family receptor alpha like 3.44794
DMRT1 doublesex and mab-3 related transcription factor 1 3.44794
OR14A16 olfactory receptor, family 14, subfamily A, member 16 3.44794
NT5C1B 5'-nucleotidase, cytosolic IB 3.44794
CD80 CD80 molecule 3.44794
CD86 CD86 molecule 3.44794
AMER3 APC membrane recruitment protein 3 3.44794
CARD6 caspase recruitment domain family, member 6 3.44794
KLHL1 kelch-like family member 1 3.44794
APOC4 apolipoprotein C-IV 3.44794
RBMXL3 RNA binding motif protein, X-linked-like 3 3.44794
RANBP3L RAN binding protein 3-like 3.44794
TBXA2R thromboxane A2 receptor 3.44794
EMX2 empty spiracles homeobox 2 3.44794
GLYATL3 glycine-N-acyltransferase-like 3 3.44794
DRD4 dopamine receptor D4 3.44794
PCDHGA4 protocadherin gamma subfamily A, 4 3.44794
PMP2 peripheral myelin protein 2 3.44794
VWA3B von Willebrand factor A domain containing 3B 3.44794
TEKT2 tektin 2 (testicular) 3.44794
HCAR3 hydroxycarboxylic acid receptor 3 3.44794
NKX6-2 NK6 homeobox 2 3.44794
HAND1 heart and neural crest derivatives expressed 1 3.44794
TMEM215 transmembrane protein 215 3.44794
PCDHGB1 protocadherin gamma subfamily B, 1 3.44794
BOD1L2 biorientation of chromosomes in cell division 1-like 2 3.44794
C22ORF31 chromosome 22 open reading frame 31 3.44794
MNX1 motor neuron and pancreas homeobox 1 3.44794
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 3.44794
CD37 CD37 molecule 3.44794
CLCF1 cardiotrophin-like cytokine factor 1 3.44794
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.44794
GOLGA8R golgin A8 family, member R 3.44794
PHOX2A paired-like homeobox 2a 3.44794
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.44794
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 3.44794
PADI3 peptidyl arginine deiminase, type III 3.44794
LRRN4 leucine rich repeat neuronal 4 3.44794
KRTAP5-2 keratin associated protein 5-2 3.44794
THEM5 thioesterase superfamily member 5 3.44794
GPR146 G protein-coupled receptor 146 3.44794
RIPK3 receptor-interacting serine-threonine kinase 3 3.44794
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.44794
GJB6 gap junction protein, beta 6, 30kDa 3.44794
FOXP3 forkhead box P3 3.44794
GREM1 gremlin 1, DAN family BMP antagonist 3.44794
HEPN1 hepatocellular carcinoma, down-regulated 1 3.44794
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 3.44794
FBXL7 F-box and leucine-rich repeat protein 7 3.29356
FSTL4 follistatin-like 4 3.18324
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.80861
USP54 ubiquitin specific peptidase 54 2.74009
NHEJ1 nonhomologous end-joining factor 1 2.68424
CENPU centromere protein U 2.67463
GPI glucose-6-phosphate isomerase 2.65024
ZNF3 zinc finger protein 3 2.4945
EBF2 early B-cell factor 2 2.45562
PDCL2 phosducin-like 2 2.45562
SCARA5 scavenger receptor class A, member 5 2.45562
FAM107B family with sequence similarity 107, member B 2.449
C3ORF52 chromosome 3 open reading frame 52 2.44228
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2.43148
CDC5L cell division cycle 5-like 2.43047
RPUSD2 RNA pseudouridylate synthase domain containing 2 2.40572
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 2.39493
GLI1 GLI family zinc finger 1 2.38515
MCUB mitochondrial calcium uniporter dominant negative subunit beta 2.38515
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.38515
MARK4 MAP/microtubule affinity-regulating kinase 4 2.33817
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.33817
LDHD lactate dehydrogenase D 2.33817
ASB2 ankyrin repeat and SOCS box containing 2 2.33817
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.33817
SMIM10 small integral membrane protein 10 2.32261
ZNF627 zinc finger protein 627 2.32261
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 2.31896
TMC4 transmembrane channel-like 4 2.31379
CUL1 cullin 1 2.30349
ETNPPL ethanolamine-phosphate phospho-lyase 2.29719
NEK8 NIMA-related kinase 8 2.28309
CD8A CD8a molecule 2.27553
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 2.24405
TRIB2 tribbles pseudokinase 2 2.24326
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 2.22957
TIMCC TIM double twin CX3C motif chaperone 2.22954
TRIM35 tripartite motif containing 35 2.19257
CEP57 centrosomal protein 57kDa 2.18773
SRRT serrate, RNA effector molecule 2.18459
MOSPD3 motile sperm domain containing 3 2.17316
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.14187
LAMB2 laminin, beta 2 (laminin S) 2.13702
NDN necdin, melanoma antigen (MAGE) family member 2.12976
AIG1 androgen-induced 1 2.12331
NECTIN3 nectin cell adhesion molecule 3 2.09439
YPEL5 yippee-like 5 (Drosophila) 2.09439
CLTC clathrin, heavy chain (Hc) 2.08045
REEP3 receptor accessory protein 3 2.07274
FBXO44 F-box protein 44 2.07274
AFTPH aftiphilin 2.07241
GLMN glomulin, FKBP associated protein 2.05909
SLFNL1 schlafen-like 1 2.05618
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.05618
SCN5A sodium channel, voltage gated, type V alpha subunit 2.04196
FGGY FGGY carbohydrate kinase domain containing 2.02615
PAAF1 proteasomal ATPase-associated factor 1 2.02193
CAMKV CaM kinase-like vesicle-associated 2.00652
PDE4A phosphodiesterase 4A, cAMP-specific 2.00472

decreased expression

Symbol Name Standardized Value
CLC Charcot-Leyden crystal galectin -3.51194
C1QTNF12 C1q and TNF related 12 -3.51194
ALX3 ALX homeobox 3 -3.51194
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -3.51194
DRICH1 aspartate-rich 1 -3.51194
C1QTNF7 C1q and tumor necrosis factor related protein 7 -3.44794
FAM131C family with sequence similarity 131, member C -3.44794
FBXW12 F-box and WD repeat domain containing 12 -3.44794
LGALS3 lectin, galactoside-binding, soluble, 3 -3.44794
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 -3.44794
C11ORF86 chromosome 11 open reading frame 86 -3.44794
FRMPD2 FERM and PDZ domain containing 2 -3.44794
KCNK15 potassium channel, two pore domain subfamily K, member 15 -3.44794
NPPC natriuretic peptide C -3.44794
HCRTR1 hypocretin (orexin) receptor 1 -3.44794
BTC betacellulin -3.44794
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -3.44794
OSGIN1 oxidative stress induced growth inhibitor 1 -3.44794
ASPA aspartoacylase -3.44794
RGS11 regulator of G-protein signaling 11 -3.44794
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -3.44794
UTS2B urotensin 2B -3.44794
TEX12 testis expressed 12 -3.44794
HLA-DOB major histocompatibility complex, class II, DO beta -3.44794
LY96 lymphocyte antigen 96 -3.44794
SCNN1B sodium channel, non voltage gated 1 beta subunit -3.44794
TERB1 telomere repeat binding bouquet formation protein 1 -3.44794
PRM1 protamine 1 -3.44794
H2BC4 H2B clustered histone 4 -3.44794
USP46 ubiquitin specific peptidase 46 -3.44794
CLUL1 clusterin-like 1 (retinal) -3.44794
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -3.44794
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -3.44794
STRC stereocilin -3.44794
GPR12 G protein-coupled receptor 12 -3.44794
C5ORF47 chromosome 5 open reading frame 47 -3.32343
RNF130 ring finger protein 130 -3.13817
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -3.03408
OR52A1 olfactory receptor, family 52, subfamily A, member 1 -2.99762
PNMT phenylethanolamine N-methyltransferase -2.99039
MYD88 myeloid differentiation primary response 88 -2.85487
NRBP2 nuclear receptor binding protein 2 -2.79064
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase -2.75238
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.6963
CCDC74A coiled-coil domain containing 74A -2.658
WDR27 WD repeat domain 27 -2.63127
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 -2.4693
UBP1 upstream binding protein 1 (LBP-1a) -2.45921
PUS3 pseudouridylate synthase 3 -2.45562
REC8 REC8 meiotic recombination protein -2.42632
GPR108 G protein-coupled receptor 108 -2.40248
ZNF398 zinc finger protein 398 -2.40248
CCDC88B coiled-coil domain containing 88B -2.40248
SAXO4 stabilizer of axonemal microtubules 4 -2.33817
ACMSD aminocarboxymuconate semialdehyde decarboxylase -2.33817
PLAGL2 pleiomorphic adenoma gene-like 2 -2.3266
AR androgen receptor -2.3266
GCLC glutamate-cysteine ligase, catalytic subunit -2.32261
RCSD1 RCSD domain containing 1 -2.32261
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -2.32261
LYG1 lysozyme G-like 1 -2.32261
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) -2.32261
SLA2 Src-like-adaptor 2 -2.32261
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -2.32261
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.32261
LPAR6 lysophosphatidic acid receptor 6 -2.32261
VENTX VENT homeobox -2.32261
FAM177A1 family with sequence similarity 177, member A1 -2.31896
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -2.31379
TMEM81 transmembrane protein 81 -2.31379
ARL16 ADP-ribosylation factor-like 16 -2.30349
NOS2 nitric oxide synthase 2, inducible -2.29719
FGFR3 fibroblast growth factor receptor 3 -2.29719
WWC1 WW and C2 domain containing 1 -2.29719
ABHD2 abhydrolase domain containing 2 -2.28879
SUGP1 SURP and G patch domain containing 1 -2.26759
NIPAL2 NIPA-like domain containing 2 -2.26583
SUMO3 small ubiquitin-like modifier 3 -2.2442
ZNF644 zinc finger protein 644 -2.24326
ITM2C integral membrane protein 2C -2.2358
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -2.18773
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.18773
OVCH2 ovochymase 2 (gene/pseudogene) -2.18157
DAP3 death associated protein 3 -2.17993
UBE2M ubiquitin-conjugating enzyme E2M -2.17993
LRRCC1 leucine rich repeat and coiled-coil centrosomal protein 1 -2.17993
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.16619
EVA1A eva-1 homolog A (C. elegans) -2.15893
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -2.15893
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -2.15064
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.09439
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific -2.09439
KAT5 K(lysine) acetyltransferase 5 -2.07274
VCP valosin containing protein -2.06348
DPH5 diphthamide biosynthesis 5 -2.05822
SMC4 structural maintenance of chromosomes 4 -2.05618
YBX1 Y box binding protein 1 -2.02528
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.02488
TSPOAP1 TSPO associated protein 1 -2.00009