BTRC Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description beta-transducin repeat containing E3 ubiquitin protein ligase|This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012] (NCBI Entrez Gene Database, 8945)
External Link http://www.ncbi.nlm.nih.gov/gene/8945
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277 interacting proteins for BTRC from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACSL3 acyl-CoA synthetase long-chain family member 3
AGO2 argonaute RISC catalytic component 2
AMER1 APC membrane recruitment protein 1
AMOT angiomotin
APC adenomatous polyposis coli
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ASF1A anti-silencing function 1A histone chaperone
ATAD3A ATPase family, AAA domain containing 3A
ATAD3B ATPase family, AAA domain containing 3B
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATXN10 ataxin 10
AURKA aurora kinase A
AXIN1 axin 1
BCL10 B-cell CLL/lymphoma 10
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BORA bora, aurora kinase A activator
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAND1 cullin-associated and neddylation-dissociated 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC22 coiled-coil domain containing 22
CCND1 cyclin D1
CCNE1 cyclin E1
CD4 CD4 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC34 cell division cycle 34
CHPF chondroitin polymerizing factor
CHUK conserved helix-loop-helix ubiquitous kinase
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLSPN claspin
CLU clusterin
CNTNAP1 contactin associated protein 1
COPS4 COP9 signalosome subunit 4
CP ceruloplasmin (ferroxidase)
CRY1 cryptochrome circadian clock 1
CRY2 cryptochrome circadian clock 2
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSNK2B casein kinase 2, beta polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CUL1 cullin 1
CUL4A cullin 4A
CYB5R1 cytochrome b5 reductase 1
DAGLB diacylglycerol lipase, beta
DBN1 drebrin 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DLG1 discs, large homolog 1 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
E2F4 E2F transcription factor 4, p107/p130-binding
EEF2K eukaryotic elongation factor 2 kinase
ELAVL1 ELAV like RNA binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EP300 E1A binding protein p300
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPOR erythropoietin receptor
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAF1 Fas (TNFRSF6) associated factor 1
FBXO5 F-box protein 5
FBXW11 F-box and WD repeat domain containing 11
FBXW8 F-box and WD repeat domain containing 8
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD3 FYVE, RhoGEF and PH domain containing 3
FOXO3 forkhead box O3
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GH1 growth hormone 1
GH2 growth hormone 2
GHR growth hormone receptor
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
GPRASP2 G protein-coupled receptor associated sorting protein 2
GSK3B glycogen synthase kinase 3 beta
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC3 histone deacetylase 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIPK2 homeodomain interacting protein kinase 2
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10RA interleukin 10 receptor, alpha
IPO9 importin 9
IRAK1 interleukin-1 receptor-associated kinase 1
JAK2 Janus kinase 2
JUP junction plakoglobin
KDM1A lysine (K)-specific demethylase 1A
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT79 keratin 79, type II
LRPPRC leucine-rich pentatricopeptide repeat containing
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MTSS1 metastasis suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NCOR2 nuclear receptor corepressor 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NRD1 nardilysin (N-arginine dibasic convertase)
NRF1 nuclear respiratory factor 1
NUAK1 NUAK family, SNF1-like kinase, 1
NUAK2 NUAK family, SNF1-like kinase, 2
NUDC nudC nuclear distribution protein
NUMB numb homolog (Drosophila)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OIP5 Opa interacting protein 5
PCDH8 protocadherin 8
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PER1 period circadian clock 1
PER2 period circadian clock 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLK4 polo-like kinase 4
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRDX1 peroxiredoxin 1
PREB prolactin regulatory element binding
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRL prolactin
PRLR prolactin receptor
PRMT5 protein arginine methyltransferase 5
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSME4 proteasome (prosome, macropain) activator subunit 4
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTTG1 pituitary tumor-transforming 1
RAE1 ribonucleic acid export 1
RANBP1 RAN binding protein 1
RANBP2 RAN binding protein 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCAN1 regulator of calcineurin 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REST RE1-silencing transcription factor
RNF7 ring finger protein 7
RPS27A ribosomal protein S27a
RTN3 reticulon 3
RTN4 reticulon 4
SCAMP3 secretory carrier membrane protein 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SGPL1 sphingosine-1-phosphate lyase 1
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4
SLIRP SRA stem-loop interacting RNA binding protein
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI1 snail family zinc finger 1
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SP1 Sp1 transcription factor
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP9 signal recognition particle 9kDa
SUFU suppressor of fused homolog (Drosophila)
SUN2 Sad1 and UNC84 domain containing 2
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TAZ tafazzin
TBK1 TANK-binding kinase 1
TBRG4 transforming growth factor beta regulator 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM192 transmembrane protein 192
TMEM55B transmembrane protein 55B
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TRAF3IP2 TRAF3 interacting protein 2
TRIB2 tribbles pseudokinase 2
TRIM9 tripartite motif containing 9
TSPAN15 tetraspanin 15
TUBGCP2 tubulin, gamma complex associated protein 2
TUBGCP3 tubulin, gamma complex associated protein 3
UBA1 ubiquitin-like modifier activating enzyme 1
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2R2 ubiquitin-conjugating enzyme E2R 2
UBQLN2 ubiquilin 2
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UFD1L ubiquitin fusion degradation 1 like (yeast)
UHRF1 ubiquitin-like with PHD and ring finger domains 1
USP10 ubiquitin specific peptidase 10
USP37 ubiquitin specific peptidase 37
USP47 ubiquitin specific peptidase 47
VCP valosin containing protein
WDFY3 WD repeat and FYVE domain containing 3
WEE1 WEE1 G2 checkpoint kinase
WWC1 WW and C2 domain containing 1
WWTR1 WW domain containing transcription regulator 1
XPO1 exportin 1
XPO4 exportin 4
XPO5 exportin 5
YAP1 Yes-associated protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZC3H12A zinc finger CCCH-type containing 12A
ZRANB1 zinc finger, RAN-binding domain containing 1