Babesiosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease. (Human Disease Ontology, DOID_9643)
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Genes

161 genes co-occuring with the disease Babesiosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
RAP1A RAP1A, member of RAS oncogene family 2.36
HP haptoglobin 2.284
ERV3-1 endogenous retrovirus group 3, member 1 2.25
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.25
ERVW-1 endogenous retrovirus group W, member 1 2.209
CCT7 chaperonin containing TCP1, subunit 7 (eta) 2.184
SECISBP2 SECIS binding protein 2 2.056
RPL4 ribosomal protein L4 2.055
ALB albumin 2.045
IFNG interferon, gamma 2.044
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.987
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.957
CD4 CD4 molecule 1.936
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.846
IL10 interleukin 10 1.839
TNF tumor necrosis factor 1.813
HOMER1 homer scaffolding protein 1 1.811
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.798
RPS8 ribosomal protein S8 1.789
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.773
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1.76
HSPB6 heat shock protein, alpha-crystallin-related, B6 1.749
AGBL3 ATP/GTP binding protein-like 3 1.738
RAP1B RAP1B, member of RAS oncogene family 1.727
HSPA4 heat shock 70kDa protein 4 1.699
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 1.675
AGBL2 ATP/GTP binding protein-like 2 1.66
TBP TATA box binding protein 1.657
LIPI lipase, member I 1.654
ATAD1 ATPase family, AAA domain containing 1 1.642
IL6 interleukin 6 1.64
CD8A CD8a molecule 1.63
CRP C-reactive protein, pentraxin-related 1.62
MST1R macrophage stimulating 1 receptor 1.605
IL4 interleukin 4 1.563
CTSL cathepsin L 1.558
AGBL5 ATP/GTP binding protein-like 5 1.551
F3 coagulation factor III (thromboplastin, tissue factor) 1.542
SPAG1 sperm associated antigen 1 1.532
IL1B interleukin 1, beta 1.5
DHFR dihydrofolate reductase 1.492
CBS cystathionine-beta-synthase 1.48
IL2 interleukin 2 1.471
TBL1X transducin (beta)-like 1X-linked 1.442
TF transferrin 1.421
PRDX2 peroxiredoxin 2 1.415
CTRB2 chymotrypsinogen B2 1.404
IL1A interleukin 1, alpha 1.4
CTRB1 chymotrypsinogen B1 1.398
HEATR9 HEAT repeat containing 9 1.398
CS citrate synthase 1.392
STAG1 stromal antigen 1 1.387
TNNI3 troponin I type 3 (cardiac) 1.386
CPB2 carboxypeptidase B2 (plasma) 1.375
SERGEF secretion regulating guanine nucleotide exchange factor 1.374
TXN thioredoxin 1.371
PXDNL peroxidasin-like 1.358
PXDN peroxidasin 1.356
IL18 interleukin 18 1.343
C3 complement component 3 1.339
RHD Rh blood group, D antigen 1.327
RPA4 replication protein A4, 30kDa 1.315
CALR calreticulin 1.313
DHFR2 dihydrofolate reductase 2 1.302
SUCO SUN domain containing ossification factor 1.293
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.289
TLR2 toll-like receptor 2 1.283
PON1 paraoxonase 1 1.278
F2 coagulation factor II (thrombin) 1.274
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 1.273
BTN2A1 butyrophilin, subfamily 2, member A1 1.272
PLBD2 phospholipase B domain containing 2 1.262
PRAP1 proline-rich acidic protein 1 1.258
LCN2 lipocalin 2 1.253
TPR translocated promoter region, nuclear basket protein 1.252
NKTR natural killer cell triggering receptor 1.245
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.23
LRG1 leucine-rich alpha-2-glycoprotein 1 1.226
CCL2 chemokine (C-C motif) ligand 2 1.226
G6PD glucose-6-phosphate dehydrogenase 1.217
CXCL8 chemokine (C-X-C motif) ligand 8 1.215
CA1 carbonic anhydrase I 1.212
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 1.211
YBX3 Y box binding protein 3 1.206
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 1.204
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 1.202
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.202
IL5 interleukin 5 1.199
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.197
ELANE elastase, neutrophil expressed 1.197
CP ceruloplasmin (ferroxidase) 1.195
PLG plasminogen 1.191
VWF von Willebrand factor 1.19
HPGDS hematopoietic prostaglandin D synthase 1.181
HS1BP3 HCLS1 binding protein 3 1.18
GCC2 GRIP and coiled-coil domain containing 2 1.177
METAP1 methionyl aminopeptidase 1 1.176
KRT76 keratin 76, type II 1.17
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.163
LCN9 lipocalin 9 1.161
CKB creatine kinase, brain 1.158
LMLN leishmanolysin-like (metallopeptidase M8 family) 1.154
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 1.15
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.146
PFN4 profilin family, member 4 1.146
CKMT1B creatine kinase, mitochondrial 1B 1.145
PIGV phosphatidylinositol glycan anchor biosynthesis, class V 1.143
MYCBPAP MYCBP associated protein 1.142
CKM creatine kinase, muscle 1.141
PFN3 profilin 3 1.141
C4A complement component 4A (Rodgers blood group) 1.14
HM13 histocompatibility (minor) 13 1.132
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 1.13
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 1.127
PNLIP pancreatic lipase 1.125
MILR1 mast cell immunoglobulin-like receptor 1 1.121
F12 coagulation factor XII (Hageman factor) 1.113
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 1.111
HIGD2A HIG1 hypoxia inducible domain family, member 2A 1.11
RPS5 ribosomal protein S5 1.108
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.103
CFP complement factor properdin 1.103
TLR4 toll-like receptor 4 1.098
CA4 carbonic anhydrase IV 1.097
PTMS parathymosin 1.091
RAB4A-AS1 RAB4A antisense RNA 1 1.09
DHODH dihydroorotate dehydrogenase (quinone) 1.084
HEPH hephaestin 1.076
LGMN legumain 1.076
HRG histidine-rich glycoprotein 1.075
CA5A carbonic anhydrase VA, mitochondrial 1.069
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 1.069
CXCL10 chemokine (C-X-C motif) ligand 10 1.066
CTSB cathepsin B 1.065
ADCY10 adenylate cyclase 10 (soluble) 1.065
CRPPA CDP-L-ribitol pyrophosphorylase A 1.062
CENPV centromere protein V 1.062
APOA1 apolipoprotein A-I 1.061
GC group-specific component (vitamin D binding protein) 1.059
PHKA2 phosphorylase kinase, alpha 2 (liver) 1.057
ORM2 orosomucoid 2 1.057
PRF1 perforin 1 (pore forming protein) 1.054
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.048
MYH14 myosin, heavy chain 14, non-muscle 1.047
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 1.047
B3GAT1 beta-1,3-glucuronyltransferase 1 1.037
CTSH cathepsin H 1.033
HPX hemopexin 1.032
CD2 CD2 molecule 1.032
ORM1 orosomucoid 1 1.031
POMC proopiomelanocortin 1.024
MORC1 MORC family CW-type zinc finger 1 1.023
CBY1 chibby homolog 1 (Drosophila) 1.02
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 1.019
A2M alpha-2-macroglobulin 1.014
KRTAP1-1 keratin associated protein 1-1 1.012
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.011
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.01
GPX7 glutathione peroxidase 7 1.007
OLA1 Obg-like ATPase 1 1.007
ICAM1 intercellular adhesion molecule 1 1.004