Bacterial invasion of epithelial cells Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signalling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton. (Kyoto Encyclopedia of Genes and Genomes, hsa05100)
External Link https://www.kegg.jp/entry/hsa05100
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Genes

78 proteins participating in the Bacterial invasion of epithelial cells pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ACTR3C ARP3 actin-related protein 3 homolog C (yeast)
ARHGAP10 Rho GTPase activating protein 10
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4-TTLL3 ARPC4-TTLL3 readthrough
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARPC5L actin related protein 2/3 complex, subunit 5-like
BCAR1 breast cancer anti-estrogen resistance 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD2AP CD2-associated protein
CDC42 cell division cycle 42
CLSTN1 calsyntenin 1
CLTA clathrin, light chain A
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOCK1 dedicator of cytokinesis 1
ELMO1 engulfment and cell motility 1
ELMO2 engulfment and cell motility 2
ELMO3 engulfment and cell motility 3
FN1 fibronectin 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HCLS1 hematopoietic cell-specific Lyn substrate 1
ILK integrin-linked kinase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
LNCEGFL7OS lncRNA EGFL7 opposite strand
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
POTEF POTE ankyrin domain family, member F
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
RHOA ras homolog family member A
RHOG ras homolog family member G
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SEPTIN1 septin 1
SEPTIN11 septin 11
SEPTIN12 septin 12
SEPTIN2 septin 2
SEPTIN3 septin 3
SEPTIN6 septin 6
SEPTIN8 septin 8
SEPTIN9 septin 9
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SLTM SAFB-like, transcription modulator
SRC SRC proto-oncogene, non-receptor tyrosine kinase
VCL vinculin
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like