| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus. (Chemical Entities of Biological Interest Ontology, CHEBI_22689) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6436223 |
| Similar Terms | |
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197 proteins with high or low expression in Bafilomycin A1 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ADM | adrenomedullin | 4.78 |
| FN1 | fibronectin 1 | 4.46 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 4.14 |
| ANGPTL4 | angiopoietin-like 4 | 4.13 |
| TMEM59 | transmembrane protein 59 | 3.98 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 3.43 |
| NDFIP1 | Nedd4 family interacting protein 1 | 3.39 |
| ITM2B | integral membrane protein 2B | 3.31 |
| STC2 | stanniocalcin 2 | 3.3 |
| FGB | fibrinogen beta chain | 3.28 |
| ITM2C | integral membrane protein 2C | 3.2 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 3.18 |
| LDLR | low density lipoprotein receptor | 3.09 |
| FGA | fibrinogen alpha chain | 3.06 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 3.06 |
| AREG | amphiregulin | 3.02 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 3.0 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 2.84 |
| MSMO1 | methylsterol monooxygenase 1 | 2.83 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 2.81 |
| LOXL2 | lysyl oxidase-like 2 | 2.76 |
| GINM1 | glycoprotein integral membrane 1 | 2.73 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 2.71 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 2.71 |
| CLSTN1 | calsyntenin 1 | 2.7 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 2.69 |
| APP | amyloid beta (A4) precursor protein | 2.62 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 2.61 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 2.54 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 2.51 |
| HGFAC | HGF activator | 2.49 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 2.46 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 2.42 |
| LPIN1 | lipin 1 | 2.34 |
| OSMR | oncostatin M receptor | 2.31 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.27 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 2.26 |
| MVK | mevalonate kinase | 2.26 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 2.25 |
| JAG1 | jagged 1 | 2.24 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 2.23 |
| SQLE | squalene epoxidase | 2.2 |
| EREG | epiregulin | 2.18 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 2.17 |
| IFNGR1 | interferon gamma receptor 1 | 2.17 |
| GJB3 | gap junction protein, beta 3, 31kDa | 2.13 |
| CLU | clusterin | 2.11 |
| SLC38A2 | solute carrier family 38, member 2 | 2.1 |
| RNF149 | ring finger protein 149 | 2.09 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 2.05 |
| ALDOC | aldolase C, fructose-bisphosphate | 2.04 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 2.03 |
| FGFR4 | fibroblast growth factor receptor 4 | 2.02 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 2.0 |
| DHCR7 | 7-dehydrocholesterol reductase | 1.99 |
| GRN | granulin | 1.98 |
| JUN | jun proto-oncogene | 1.96 |
| COL12A1 | collagen, type XII, alpha 1 | 1.92 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 1.9 |
| KDM3A | lysine (K)-specific demethylase 3A | 1.87 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 1.87 |
| NCOA4 | nuclear receptor coactivator 4 | 1.86 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 1.85 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 1.84 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 1.82 |
| NRP1 | neuropilin 1 | 1.8 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 1.8 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 1.79 |
| SDC4 | syndecan 4 | 1.75 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 1.75 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 1.74 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 1.74 |
| DHCR24 | 24-dehydrocholesterol reductase | 1.73 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 1.73 |
| VCAN | versican | 1.72 |
| SERINC1 | serine incorporator 1 | 1.72 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 1.71 |
| CLDND1 | claudin domain containing 1 | 1.71 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 1.71 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 1.71 |
| PAH | phenylalanine hydroxylase | 1.71 |
| UNC5B | unc-5 homolog B (C. elegans) | 1.69 |
| PLAU | plasminogen activator, urokinase | 1.69 |
| FAT1 | FAT atypical cadherin 1 | 1.67 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | 1.67 |
| FDPS | farnesyl diphosphate synthase | 1.67 |
| RAET1G | retinoic acid early transcript 1G | 1.67 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 1.67 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | 1.67 |
| GDF15 | growth differentiation factor 15 | 1.66 |
| NBR1 | neighbor of BRCA1 gene 1 | 1.66 |
| SERINC3 | serine incorporator 3 | 1.64 |
| SC5D | sterol-C5-desaturase | 1.64 |
| FGFR1 | fibroblast growth factor receptor 1 | 1.63 |
| CST3 | cystatin C | 1.63 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 1.61 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 1.61 |
| GAS6 | growth arrest-specific 6 | 1.6 |
| F2R | coagulation factor II (thrombin) receptor | 1.58 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NTHL1 | nth endonuclease III-like 1 (E. coli) | -2.73 |
| ODC1 | ornithine decarboxylase 1 | -2.13 |
| FDX1 | ferredoxin 1 | -2.09 |
| MUTYH | mutY homolog | -2.06 |
| MSX1 | msh homeobox 1 | -2.05 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -1.98 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -1.85 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -1.85 |
| FADS3 | fatty acid desaturase 3 | -1.7 |
| PRELID1 | PRELI domain containing 1 | -1.66 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -1.63 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -1.59 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | -1.56 |
| CDCA7 | cell division cycle associated 7 | -1.54 |
| NAGA | N-acetylgalactosaminidase, alpha- | -1.52 |
| CDT1 | chromatin licensing and DNA replication factor 1 | -1.51 |
| MAGEA2 | melanoma antigen family A2 | -1.47 |
| SDE2 | SDE2 telomere maintenance homolog (S. pombe) | -1.43 |
| CCNG1 | cyclin G1 | -1.42 |
| LIAS | lipoic acid synthetase | -1.34 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | -1.32 |
| SIRT3 | sirtuin 3 | -1.3 |
| H1-2 | H1.2 linker histone, cluster member | -1.3 |
| CISD3 | CDGSH iron sulfur domain 3 | -1.29 |
| PLIN2 | perilipin 2 | -1.29 |
| FAM104A | family with sequence similarity 104, member A | -1.29 |
| TPM2 | tropomyosin 2 (beta) | -1.29 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -1.29 |
| UROS | uroporphyrinogen III synthase | -1.28 |
| FECH | ferrochelatase | -1.27 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -1.26 |
| CDC20 | cell division cycle 20 | -1.26 |
| FTH1 | ferritin, heavy polypeptide 1 | -1.24 |
| PPT1 | palmitoyl-protein thioesterase 1 | -1.23 |
| POLE | polymerase (DNA directed), epsilon, catalytic subunit | -1.23 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | -1.23 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | -1.23 |
| OBI1 | ORC ubiquitin ligase 1 | -1.22 |
| PRELID3B | PRELI domain containing 3B | -1.22 |
| HES1 | hes family bHLH transcription factor 1 | -1.21 |
| DES | desmin | -1.2 |
| PARPBP | PARP1 binding protein | -1.19 |
| METTL17 | methyltransferase like 17 | -1.19 |
| TMEM102 | transmembrane protein 102 | -1.19 |
| PAQR7 | progestin and adipoQ receptor family member VII | -1.19 |
| CCDC85B | coiled-coil domain containing 85B | -1.19 |
| GAS8 | growth arrest-specific 8 | -1.18 |
| CDC25B | cell division cycle 25B | -1.18 |
| DPP7 | dipeptidyl-peptidase 7 | -1.18 |
| CPVL | carboxypeptidase, vitellogenic-like | -1.18 |
| CDK5RAP1 | CDK5 regulatory subunit associated protein 1 | -1.17 |
| RBIS | ribosomal biogenesis factor | -1.17 |
| MRFAP1 | Morf4 family associated protein 1 | -1.17 |
| DZIP3 | DAZ interacting zinc finger protein 3 | -1.15 |
| POLR3G | polymerase (RNA) III (DNA directed) polypeptide G (32kD) | -1.15 |
| CCNF | cyclin F | -1.15 |
| NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D | -1.15 |
| TTC12 | tetratricopeptide repeat domain 12 | -1.14 |
| CTSZ | cathepsin Z | -1.14 |
| TBC1D30 | TBC1 domain family, member 30 | -1.14 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | -1.13 |
| ZNF580 | zinc finger protein 580 | -1.13 |
| AEN | apoptosis enhancing nuclease | -1.12 |
| GPX1 | glutathione peroxidase 1 | -1.12 |
| CCDC14 | coiled-coil domain containing 14 | -1.12 |
| NDUFS8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) | -1.12 |
| CGNL1 | cingulin-like 1 | -1.12 |
| CETN3 | centrin, EF-hand protein, 3 | -1.12 |
| VIM | vimentin | -1.11 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | -1.11 |
| CUEDC2 | CUE domain containing 2 | -1.11 |
| PLD6 | phospholipase D family, member 6 | -1.1 |
| EPDR1 | ependymin related 1 | -1.1 |
| IVNS1ABP | influenza virus NS1A binding protein | -1.1 |
| ELP3 | elongator acetyltransferase complex subunit 3 | -1.1 |
| NDUFA2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa | -1.1 |
| AFTPH | aftiphilin | -1.1 |
| AMD1 | adenosylmethionine decarboxylase 1 | -1.09 |
| SLC25A39 | solute carrier family 25, member 39 | -1.08 |
| ATF7IP | activating transcription factor 7 interacting protein | -1.08 |
| FUCA1 | fucosidase, alpha-L- 1, tissue | -1.08 |
| CENPE | centromere protein E, 312kDa | -1.07 |
| HOXA7 | homeobox A7 | -1.07 |
| MSX2 | msh homeobox 2 | -1.06 |
| POLD1 | polymerase (DNA directed), delta 1, catalytic subunit | -1.05 |
| SCPEP1 | serine carboxypeptidase 1 | -1.05 |
| HEXA | hexosaminidase A (alpha polypeptide) | -1.04 |
| DPH1 | diphthamide biosynthesis 1 | -1.04 |
| WASHC3 | WASH complex subunit 3 | -1.04 |
| OTUD5 | OTU deubiquitinase 5 | -1.04 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -1.04 |
| SPC24 | SPC24, NDC80 kinetochore complex component | -1.04 |
| TPM4 | tropomyosin 4 | -1.03 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | -1.03 |
| SNAP23 | synaptosomal-associated protein, 23kDa | -1.03 |
| UCK1 | uridine-cytidine kinase 1 | -1.03 |
| GLB1 | galactosidase, beta 1 | -1.02 |
| SYTL3 | synaptotagmin-like 3 | -1.02 |
