Baicalin_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.192019
TRIO trio Rho guanine nucleotide exchange factor 0.158995
COL5A1 collagen, type V, alpha 1 0.151636
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.149033
PODXL podocalyxin-like 0.143065
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.13638
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.124435
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.112303
IGFBP3 insulin-like growth factor binding protein 3 0.109606
NAV1 neuron navigator 1 0.10691
SLC39A11 solute carrier family 39, member 11 0.0892496
DST dystonin 0.0810237
FN1 fibronectin 1 0.0802293
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0788236
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0772231
FLNA filamin A, alpha 0.0746215
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0727647
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0724052
MACF1 microtubule-actin crosslinking factor 1 0.0711005
EGFR epidermal growth factor receptor 0.0698469
COL8A1 collagen, type VIII, alpha 1 0.0695847
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0694843
AHNAK AHNAK nucleoprotein 0.0680357
PBX3 pre-B-cell leukemia homeobox 3 0.0672184
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0638936
MAP1B microtubule-associated protein 1B 0.0611303
EFNA5 ephrin-A5 0.0589154
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0583295
ASPH aspartate beta-hydroxylase 0.0576541
CYTH3 cytohesin 3 0.0552085
AKAP12 A kinase (PRKA) anchor protein 12 0.0530344
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0512058
FNDC3B fibronectin type III domain containing 3B 0.0510434
MSN moesin 0.0505663
FLNB filamin B, beta 0.048538
MYOF myoferlin 0.0484194
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0477831
RUNX1 runt-related transcription factor 1 0.0476892
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0469202
NAV2 neuron navigator 2 0.0461565
MYH9 myosin, heavy chain 9, non-muscle 0.0447936
PLEC plectin 0.0447715
AUTS2 autism susceptibility candidate 2 0.0437896
FSTL1 follistatin-like 1 0.0432705
PALM2AKAP2 PALM2 and AKAP2 fusion 0.042492
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0422686
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.041894
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0416565
COPA coatomer protein complex, subunit alpha 0.0414213
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0412976
INTS6 integrator complex subunit 6 0.0406933
PRELID2 PRELI domain containing 2 0.0406551
PLAT plasminogen activator, tissue 0.0400056
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.039914
DCLK2 doublecortin-like kinase 2 0.038637
MCL1 myeloid cell leukemia 1 0.0384724
ADAM9 ADAM metallopeptidase domain 9 0.0382677
DOCK5 dedicator of cytokinesis 5 0.0375956
VCL vinculin 0.0374433
CUX1 cut-like homeobox 1 0.0374324
HDAC9 histone deacetylase 9 0.0371681
ABI3BP ABI family, member 3 (NESH) binding protein 0.0371427
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0362867
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0361181
SEPTIN9 septin 9 0.0356994
NCOR2 nuclear receptor corepressor 2 0.0353059
RASAL2 RAS protein activator like 2 0.0352945
SORBS2 sorbin and SH3 domain containing 2 0.0349983
SDK1 sidekick cell adhesion molecule 1 0.0345724
MSI2 musashi RNA-binding protein 2 0.0345619
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0343817
L1CAM L1 cell adhesion molecule 0.0341125
RNF144A ring finger protein 144A 0.0341081
PDE10A phosphodiesterase 10A 0.0340256
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0340207
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0338963
TENM3 teneurin transmembrane protein 3 0.033401
TIMP2 TIMP metallopeptidase inhibitor 2 0.033212
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0328855
DGKG diacylglycerol kinase, gamma 90kDa 0.032517
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0324833
EXT1 exostosin glycosyltransferase 1 0.0324189
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.0323913
PLXNA2 plexin A2 0.0319875
CD44 CD44 molecule (Indian blood group) 0.0319315
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0317149
ZFP36L1 ZFP36 ring finger protein-like 1 0.0316445
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0313184
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0312111
RIGI RNA sensor RIG-I 0.0310364
ANKRD11 ankyrin repeat domain 11 0.0309938
DSPP dentin sialophosphoprotein 0.0305133
CEP170 centrosomal protein 170kDa 0.0301189
FLT1 fms-related tyrosine kinase 1 0.0300153
ZEB1 zinc finger E-box binding homeobox 1 0.0294451
MED13L mediator complex subunit 13-like 0.0294008
PDE4D phosphodiesterase 4D, cAMP-specific 0.0291528
COL5A2 collagen, type V, alpha 2 0.0288108
NEK7 NIMA-related kinase 7 0.0283931
ALCAM activated leukocyte cell adhesion molecule 0.0283043

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.141356
MT2A metallothionein 2A -0.135356
TMSB10 thymosin beta 10 -0.0960875
VIM vimentin -0.0865928
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0839491
B2M beta-2-microglobulin -0.0773566
HLA-B major histocompatibility complex, class I, B -0.0721682
FBN1 fibrillin 1 -0.0680495
PTMA prothymosin, alpha -0.0543024
CSTB cystatin B (stefin B) -0.0500255
COL3A1 collagen, type III, alpha 1 -0.0497701
EIF1 eukaryotic translation initiation factor 1 -0.049611
S100A6 S100 calcium binding protein A6 -0.046643
S100A10 S100 calcium binding protein A10 -0.0465041
IFITM3 interferon induced transmembrane protein 3 -0.0416865
COL1A2 collagen, type I, alpha 2 -0.0390996
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0373262
TPT1 tumor protein, translationally-controlled 1 -0.0371894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0363521
THBS2 thrombospondin 2 -0.0360315
FTH1 ferritin, heavy polypeptide 1 -0.035801
HLA-E major histocompatibility complex, class I, E -0.0334356
IFITM1 interferon induced transmembrane protein 1 -0.0322007
FTL ferritin, light polypeptide -0.032006
RPL12 ribosomal protein L12 -0.031659
RPL35A ribosomal protein L35a -0.0313683
NAP1L1 nucleosome assembly protein 1-like 1 -0.029276
DLG1 discs, large homolog 1 (Drosophila) -0.0288514
MEIS2 Meis homeobox 2 -0.0279362
RPS3 ribosomal protein S3 -0.0273881
RPS8 ribosomal protein S8 -0.0260685
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0254662
RPLP1 ribosomal protein, large, P1 -0.0253942
HLA-C major histocompatibility complex, class I, C -0.0245953
RPL26 ribosomal protein L26 -0.0244567
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0241482
RPL23 ribosomal protein L23 -0.0238886
RPL28 ribosomal protein L28 -0.0236059
RACK1 receptor for activated C kinase 1 -0.0233738
NDRG1 N-myc downstream regulated 1 -0.0229721
RPS6 ribosomal protein S6 -0.0228979
RHOBTB3 Rho-related BTB domain containing 3 -0.0227226
RPL36 ribosomal protein L36 -0.0226779
LOC102724023 ES1 protein homolog, mitochondrial -0.022539
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0224488
RPS19 ribosomal protein S19 -0.022263
RPL34 ribosomal protein L34 -0.0221326
RPL19 ribosomal protein L19 -0.021797
SQSTM1 sequestosome 1 -0.0217472
TXNIP thioredoxin interacting protein -0.0216056
H3-3B H3.3 histone B -0.0212119
ANXA2 annexin A2 -0.0212008
CD99 CD99 molecule -0.020787
TMSB4X thymosin beta 4, X-linked -0.0206575
RPLP2 ribosomal protein, large, P2 -0.0205414
RPL37A ribosomal protein L37a -0.0199479
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0198057
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0190206
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0190094
IFI6 interferon, alpha-inducible protein 6 -0.0189365
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0188462
RPL35 ribosomal protein L35 -0.0188376
STC1 stanniocalcin 1 -0.0187275
TMOD1 tropomodulin 1 -0.0186804
AKAP9 A kinase (PRKA) anchor protein 9 -0.0184459
RPS24 ribosomal protein S24 -0.0182112
DPYSL3 dihydropyrimidinase-like 3 -0.0180522
MT1X metallothionein 1X -0.0178698
NPR2 natriuretic peptide receptor 2 -0.017839
PNISR PNN-interacting serine/arginine-rich protein -0.0178219
TM4SF1 transmembrane 4 L six family member 1 -0.0177232
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0177029
GOLGA4 golgin A4 -0.0176822
RAD21 RAD21 homolog (S. pombe) -0.0176798
S100A4 S100 calcium binding protein A4 -0.0176797
RPL31 ribosomal protein L31 -0.0173651
GNAS GNAS complex locus -0.0172871
TRIM56 tripartite motif containing 56 -0.0172174
RPS13 ribosomal protein S13 -0.0171245
GPC6 glypican 6 -0.0171012
OGA O-GlcNAcase -0.0168581
RPS27 ribosomal protein S27 -0.0167675
UBE2B ubiquitin-conjugating enzyme E2B -0.016767
IFI16 interferon, gamma-inducible protein 16 -0.0167605
SEC61G Sec61 gamma subunit -0.0167356
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0166505
RPS27A ribosomal protein S27a -0.0166123
NGLY1 N-glycanase 1 -0.0165811
PRRC2C proline-rich coiled-coil 2C -0.0163667
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0163382
CAVIN1 caveolae associated protein 1 -0.0162553
RPS12 ribosomal protein S12 -0.0159338
ATP5F1E ATP synthase F1 subunit epsilon -0.015787
RBM25 RNA binding motif protein 25 -0.0155857
VDAC1 voltage-dependent anion channel 1 -0.0155842
RPS16 ribosomal protein S16 -0.0154837
UBC ubiquitin C -0.0154825
WDR45B WD repeat domain 45B -0.0154514
FAM162A family with sequence similarity 162, member A -0.0153134
RPS5 ribosomal protein S5 -0.0152938