Baicalin_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.154017
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.133326
ZSWIM6 zinc finger, SWIM-type containing 6 0.124215
HMGA2 high mobility group AT-hook 2 0.121262
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.10142
CELF2 CUGBP, Elav-like family member 2 0.101212
DST dystonin 0.10097
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0953952
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0886646
PDE4D phosphodiesterase 4D, cAMP-specific 0.0852785
PCDH7 protocadherin 7 0.0758618
CMIP c-Maf inducing protein 0.0749895
INTS6 integrator complex subunit 6 0.0737792
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0699633
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0686108
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0685839
RAB7A RAB7A, member RAS oncogene family 0.0651947
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.064438
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.064343
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0634402
ACTG1 actin gamma 1 0.0630961
ADIPOR2 adiponectin receptor 2 0.0622924
YAP1 Yes-associated protein 1 0.0610597
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0575579
DPYD dihydropyrimidine dehydrogenase 0.0572563
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0563912
ERBIN erbb2 interacting protein 0.0560705
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0556346
ZFAND3 zinc finger, AN1-type domain 3 0.0555456
GSK3B glycogen synthase kinase 3 beta 0.0539434
TMSB10 thymosin beta 10 0.0539307
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0526305
LPP LIM domain containing preferred translocation partner in lipoma 0.0491317
PDGFC platelet derived growth factor C 0.0463121
MSRB3 methionine sulfoxide reductase B3 0.0460544
DLC1 DLC1 Rho GTPase activating protein 0.0456935
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0454134
ANKRD17 ankyrin repeat domain 17 0.0452284
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0450031
RASAL2 RAS protein activator like 2 0.0449724
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0416547
DENND5A DENN/MADD domain containing 5A 0.0412828
HDAC9 histone deacetylase 9 0.0398468
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0386603
NIPBL Nipped-B homolog (Drosophila) 0.0377876
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0377681
ASXL1 additional sex combs like transcriptional regulator 1 0.0374868
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0374106
CDK6 cyclin-dependent kinase 6 0.0373297
CCN2 cellular communication network factor 2 0.0372232
MARCHF4 membrane associated ring-CH-type finger 4 0.0369808
USP9X ubiquitin specific peptidase 9, X-linked 0.0363641
PHACTR4 phosphatase and actin regulator 4 0.0361189
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0360938
ZNF804A zinc finger protein 804A 0.0360563
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0348589
RIMS2 regulating synaptic membrane exocytosis 2 0.0345775
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0344927
MYPN myopalladin 0.0340912
MED13L mediator complex subunit 13-like 0.0339144
TSC22D2 TSC22 domain family, member 2 0.0336557
ASXL2 additional sex combs like transcriptional regulator 2 0.0332731
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0330071
NRXN3 neurexin 3 0.0328621
RCOR1 REST corepressor 1 0.0327371
EXOC6B exocyst complex component 6B 0.032631
LMO7 LIM domain 7 0.0323843
ZEB1 zinc finger E-box binding homeobox 1 0.0322907
EZR ezrin 0.0321383
ZNF638 zinc finger protein 638 0.0318729
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0313589
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0311598
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0311206
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0310906
RAB10 RAB10, member RAS oncogene family 0.0310549
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0309449
EIF4A2 eukaryotic translation initiation factor 4A2 0.0308082
DTNA dystrobrevin, alpha 0.030408
SLC38A2 solute carrier family 38, member 2 0.0302895
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0302715
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0301836
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0300175
OSBPL8 oxysterol binding protein-like 8 0.0297299
TMEM181 transmembrane protein 181 0.029115
BIRC3 baculoviral IAP repeat containing 3 0.0289248
CCND1 cyclin D1 0.0288264
TGM2 transglutaminase 2 0.0287933
DUSP16 dual specificity phosphatase 16 0.0286668
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.027997
FXR1 fragile X mental retardation, autosomal homolog 1 0.0278367
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0277877
CCSER1 coiled-coil serine-rich protein 1 0.0273971
RPTOR regulatory associated protein of MTOR, complex 1 0.0273844
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0272608
NFIB nuclear factor I/B 0.0272079
AXIN2 axin 2 0.0271708
FNDC3B fibronectin type III domain containing 3B 0.0270629
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0267114
PUM1 pumilio RNA-binding family member 1 0.026703
JMJD1C jumonji domain containing 1C 0.0264974

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.0668561
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0520826
TMEM41B transmembrane protein 41B -0.0481709
VIM vimentin -0.0442414
PDIA6 protein disulfide isomerase family A, member 6 -0.0385399
RPS6 ribosomal protein S6 -0.0325733
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0309985
IFIH1 interferon induced with helicase C domain 1 -0.0309869
KLHL24 kelch-like family member 24 -0.0299649
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0298165
EHBP1 EH domain binding protein 1 -0.0292814
EEF2 eukaryotic translation elongation factor 2 -0.0270905
ZNF292 zinc finger protein 292 -0.0268195
SESN2 sestrin 2 -0.0268154
TNPO1 transportin 1 -0.0266777
BCHE butyrylcholinesterase -0.0262664
PDIA3 protein disulfide isomerase family A, member 3 -0.0260914
KDM3A lysine (K)-specific demethylase 3A -0.0252347
YEATS2 YEATS domain containing 2 -0.0250864
NUP58 nucleoporin 58 -0.0243524
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0243025
ADAM9 ADAM metallopeptidase domain 9 -0.0231996
RAB1A RAB1A, member RAS oncogene family -0.0231066
PTMA prothymosin, alpha -0.0229491
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.022715
H1-0 H1.0 linker histone -0.0222142
IMMT inner membrane protein, mitochondrial -0.0220365
RPS27A ribosomal protein S27a -0.0215235
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0214676
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0208448
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0207267
S100A6 S100 calcium binding protein A6 -0.0205959
PREPL prolyl endopeptidase-like -0.0204515
IPO11 importin 11 -0.0203348
SFXN1 sideroflexin 1 -0.0202775
BRWD3 bromodomain and WD repeat domain containing 3 -0.0202769
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0201533
ZFP64 ZFP64 zinc finger protein -0.0200496
CDK19 cyclin-dependent kinase 19 -0.0200408
RPLP1 ribosomal protein, large, P1 -0.0195716
XPO1 exportin 1 -0.0194278
PNN pinin, desmosome associated protein -0.0192179
TPM3 tropomyosin 3 -0.0191626
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0190326
NIPSNAP2 nipsnap homolog 2 -0.0189654
RPL13A ribosomal protein L13a -0.0186265
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0184886
GARS1 glycyl-tRNA synthetase 1 -0.0183019
CENPF centromere protein F, 350/400kDa -0.0181476
BIRC2 baculoviral IAP repeat containing 2 -0.017844
MXI1 MAX interactor 1, dimerization protein -0.0178359
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0178072
KIF18B kinesin family member 18B -0.0174044
EIF4B eukaryotic translation initiation factor 4B -0.0173876
KIF5B kinesin family member 5B -0.0172799
SINHCAF SIN3-HDAC complex associated factor -0.0172263
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0171117
AFG3L2 AFG3-like AAA ATPase 2 -0.0166945
IFNAR2 interferon (alpha, beta and omega) receptor 2 -0.0166943
TPT1 tumor protein, translationally-controlled 1 -0.0166745
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.0165488
RPL26 ribosomal protein L26 -0.016423
BLZF1 basic leucine zipper nuclear factor 1 -0.0164215
RPL35A ribosomal protein L35a -0.0163409
HLTF helicase-like transcription factor -0.0163185
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0162722
CEP95 centrosomal protein 95kDa -0.0161717
WDPCP WD repeat containing planar cell polarity effector -0.0161704
CANX calnexin -0.0161076
ZNF652 zinc finger protein 652 -0.0160864
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.015875
NOP58 NOP58 ribonucleoprotein -0.0158521
MKI67 marker of proliferation Ki-67 -0.0157075
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0157021
NKTR natural killer cell triggering receptor -0.0157013
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0156694
HMGA1 high mobility group AT-hook 1 -0.015514
RPLP0 ribosomal protein, large, P0 -0.0154481
MIS18BP1 MIS18 binding protein 1 -0.0153557
NAMPT nicotinamide phosphoribosyltransferase -0.015302
DEK DEK proto-oncogene -0.0152501
GOLT1A golgi transport 1A -0.0152352
ETV5 ets variant 5 -0.0152289
CCNL1 cyclin L1 -0.0151761
ARRDC3 arrestin domain containing 3 -0.0150644
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -0.015041
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0150224
BARD1 BRCA1 associated RING domain 1 -0.0149025
NAV3 neuron navigator 3 -0.0148855
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0147615
RBM25 RNA binding motif protein 25 -0.0147171
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.014606
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0145546
ZFR zinc finger RNA binding protein -0.014553
SPATS2 spermatogenesis associated, serine-rich 2 -0.0145363
ATXN3 ataxin 3 -0.01451
CPOX coproporphyrinogen oxidase -0.0144474
R3HDM1 R3H domain containing 1 -0.014371
PCM1 pericentriolar material 1 -0.0143611
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 -0.0143491