Baicalin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.131206
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0815304
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0787633
MSI2 musashi RNA-binding protein 2 0.0749143
HELZ helicase with zinc finger 0.068087
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0595603
FAM13A family with sequence similarity 13, member A 0.0594032
VMP1 vacuole membrane protein 1 0.058828
NALF1 NALCN channel auxiliary factor 1 0.0571922
TRIB2 tribbles pseudokinase 2 0.0565632
ZMIZ1 zinc finger, MIZ-type containing 1 0.0503855
NPAS2 neuronal PAS domain protein 2 0.047311
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0462089
HILPDA hypoxia inducible lipid droplet-associated 0.0459599
VEGFA vascular endothelial growth factor A 0.045269
ZNF638 zinc finger protein 638 0.0446654
DTNA dystrobrevin, alpha 0.0445946
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0445178
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0415349
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0406567
KMT2C lysine (K)-specific methyltransferase 2C 0.0398047
LPIN1 lipin 1 0.0395448
ZSWIM6 zinc finger, SWIM-type containing 6 0.039277
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.038691
TPM1 tropomyosin 1 (alpha) 0.0376255
DNMBP dynamin binding protein 0.0373436
TLE4 transducin-like enhancer of split 4 0.0355543
PDLIM5 PDZ and LIM domain 5 0.0343314
MED13L mediator complex subunit 13-like 0.0338708
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0338321
SMYD3 SET and MYND domain containing 3 0.0334267
KDM4C lysine (K)-specific demethylase 4C 0.0330585
CTNND1 catenin (cadherin-associated protein), delta 1 0.0318425
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0317992
MYH9 myosin, heavy chain 9, non-muscle 0.0315993
THBS1 thrombospondin 1 0.0309433
PDE8A phosphodiesterase 8A 0.0302651
GSE1 Gse1 coiled-coil protein 0.0301669
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0298743
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0297342
ASPH aspartate beta-hydroxylase 0.0295601
SEPTIN9 septin 9 0.0294135
RNF150 ring finger protein 150 0.0292988
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0290211
NCOR2 nuclear receptor corepressor 2 0.0288947
SOX9 SRY (sex determining region Y)-box 9 0.0286408
COL4A1 collagen, type IV, alpha 1 0.0285419
KMT2E lysine (K)-specific methyltransferase 2E 0.0282137
FUS FUS RNA binding protein 0.0278144
FNDC3B fibronectin type III domain containing 3B 0.0276346
ZNF148 zinc finger protein 148 0.0273441
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0270871
MED13 mediator complex subunit 13 0.0268399
SLITRK6 SLIT and NTRK-like family, member 6 0.0267841
RAD51B RAD51 paralog B 0.0265075
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0261706
PRKCA protein kinase C, alpha 0.0258335
NDRG1 N-myc downstream regulated 1 0.025428
PTPRD protein tyrosine phosphatase, receptor type, D 0.025211
DDIT4 DNA-damage-inducible transcript 4 0.0251411
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0249744
INTS6 integrator complex subunit 6 0.0247879
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.024766
ACTN1 actinin, alpha 1 0.0247592
JARID2 jumonji, AT rich interactive domain 2 0.0247064
MYO1E myosin IE 0.0246938
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.02457
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0245143
SSBP3 single stranded DNA binding protein 3 0.0244872
QKI QKI, KH domain containing, RNA binding 0.023973
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0238794
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0234815
CADM1 cell adhesion molecule 1 0.0230496
ARHGAP32 Rho GTPase activating protein 32 0.022916
RYBP RING1 and YY1 binding protein 0.0228903
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0228301
SMAD3 SMAD family member 3 0.022756
BBX bobby sox homolog (Drosophila) 0.0227545
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0226768
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0226754
SCARB1 scavenger receptor class B, member 1 0.0226506
PHIP pleckstrin homology domain interacting protein 0.0225655
CXXC5 CXXC finger protein 5 0.0224472
TIMP3 TIMP metallopeptidase inhibitor 3 0.0224111
DPH6 diphthamine biosynthesis 6 0.022405
PRKCE protein kinase C, epsilon 0.0223679
RBM20 RNA binding motif protein 20 0.0221739
FERMT2 fermitin family member 2 0.0221617
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0220819
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0220377
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0218684
GRB10 growth factor receptor-bound protein 10 0.0217912
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0214096
DUSP10 dual specificity phosphatase 10 0.0213776
MCL1 myeloid cell leukemia 1 0.0212898
STK38L serine/threonine kinase 38 like 0.0211175
RARA retinoic acid receptor, alpha 0.0208413
PANK3 pantothenate kinase 3 0.0207435
TNRC6A trinucleotide repeat containing 6A 0.0204434
PCBP2 poly(rC) binding protein 2 0.0204248

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.147519
NRG1 neuregulin 1 -0.140441
SYT1 synaptotagmin I -0.100658
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0966947
PTMA prothymosin, alpha -0.0819511
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.079468
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0772796
NCAM2 neural cell adhesion molecule 2 -0.0735288
MAP1B microtubule-associated protein 1B -0.0728762
LIMCH1 LIM and calponin homology domains 1 -0.0699707
VIM vimentin -0.0665128
RPL23 ribosomal protein L23 -0.0646584
RPL35A ribosomal protein L35a -0.0623757
RPS6 ribosomal protein S6 -0.0623138
TPT1 tumor protein, translationally-controlled 1 -0.0610709
TMSB10 thymosin beta 10 -0.0603605
CADM2 cell adhesion molecule 2 -0.0582176
COL4A5 collagen, type IV, alpha 5 -0.0571349
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0556256
DLC1 DLC1 Rho GTPase activating protein -0.0545364
LSAMP limbic system-associated membrane protein -0.0530324
NBEA neurobeachin -0.0470156
GPC5 glypican 5 -0.0469737
RPL19 ribosomal protein L19 -0.0465153
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0459408
AKAP12 A kinase (PRKA) anchor protein 12 -0.0456641
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0448211
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0428637
COL1A1 collagen, type I, alpha 1 -0.0416153
TENT5A terminal nucleotidyltransferase 5A -0.0416106
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.040635
EIF1 eukaryotic translation initiation factor 1 -0.0405881
SCG2 secretogranin II -0.040411
ENO1 enolase 1, (alpha) -0.0398355
MBD5 methyl-CpG binding domain protein 5 -0.0390787
RPS24 ribosomal protein S24 -0.0390511
SOS1 son of sevenless homolog 1 (Drosophila) -0.039042
CENPF centromere protein F, 350/400kDa -0.0388001
GARS1 glycyl-tRNA synthetase 1 -0.0381475
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0367281
RPS3 ribosomal protein S3 -0.0364021
COL3A1 collagen, type III, alpha 1 -0.0359773
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0353317
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0346798
RPLP1 ribosomal protein, large, P1 -0.034436
PCDH9 protocadherin 9 -0.034416
B2M beta-2-microglobulin -0.0344121
STC1 stanniocalcin 1 -0.034229
RSL1D1 ribosomal L1 domain containing 1 -0.0342191
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0337558
RPL12 ribosomal protein L12 -0.0333186
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0330434
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.032856
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0318148
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0313754
CSDE1 cold shock domain containing E1, RNA-binding -0.0310816
ATRNL1 attractin-like 1 -0.0305282
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0302777
ACTG1 actin gamma 1 -0.0301442
KPNB1 karyopherin (importin) beta 1 -0.0299109
FTL ferritin, light polypeptide -0.0294535
RPL36 ribosomal protein L36 -0.0290808
IFI16 interferon, gamma-inducible protein 16 -0.028948
RPL11 ribosomal protein L11 -0.0287537
RPS21 ribosomal protein S21 -0.0287224
ZNF804A zinc finger protein 804A -0.0285891
KLF6 Kruppel-like factor 6 -0.0283522
NAP1L1 nucleosome assembly protein 1-like 1 -0.0282654
TNRC6B trinucleotide repeat containing 6B -0.0278341
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0277716
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0273063
S100A6 S100 calcium binding protein A6 -0.0271858
RPS5 ribosomal protein S5 -0.0269907
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0269593
AOPEP aminopeptidase O (putative) -0.0264819
IER3 immediate early response 3 -0.0263445
ITGA1 integrin, alpha 1 -0.0259889
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0258436
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0257794
CCND1 cyclin D1 -0.0257618
TOX thymocyte selection-associated high mobility group box -0.0257291
RACK1 receptor for activated C kinase 1 -0.0256592
RAD21 RAD21 homolog (S. pombe) -0.0256053
IARS1 isoleucyl-tRNA synthetase 1 -0.0255303
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0254943
CD36 CD36 molecule (thrombospondin receptor) -0.0253487
COL4A6 collagen, type IV, alpha 6 -0.0248779
ARHGAP24 Rho GTPase activating protein 24 -0.024789
RPL31 ribosomal protein L31 -0.0247407
FRMD4A FERM domain containing 4A -0.0244683
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0243691
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0243638
RPS27A ribosomal protein S27a -0.0241289
RPS8 ribosomal protein S8 -0.024116
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0235124
RHOBTB3 Rho-related BTB domain containing 3 -0.0235004
GDF15 growth differentiation factor 15 -0.0234096
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.023288
RPL37A ribosomal protein L37a -0.0232676
AFF3 AF4/FMR2 family, member 3 -0.0231249