Baicalin_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.0596105
VCL vinculin 0.0595662
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.057324
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0541558
MACC1 metastasis associated in colon cancer 1 0.0484108
LMO7 LIM domain 7 0.0474608
CANX calnexin 0.045778
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0319828
GMDS GDP-mannose 4,6-dehydratase 0.0315917
ANKHD1 ankyrin repeat and KH domain containing 1 0.0309037
DSCAM Down syndrome cell adhesion molecule 0.0297663
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0293366
PDLIM5 PDZ and LIM domain 5 0.0286708
EPS8 epidermal growth factor receptor pathway substrate 8 0.0283185
AREG amphiregulin 0.0282448
FNDC3B fibronectin type III domain containing 3B 0.0282028
ASPH aspartate beta-hydroxylase 0.0279731
SAMD4A sterile alpha motif domain containing 4A 0.0276888
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0274135
CSNK1A1 casein kinase 1, alpha 1 0.0270513
TUFT1 tuftelin 1 0.0258522
PCBP2 poly(rC) binding protein 2 0.0252399
TOX3 TOX high mobility group box family member 3 0.024959
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0244725
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0244607
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242264
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0232758
CTBP2 C-terminal binding protein 2 0.0229159
MYH9 myosin, heavy chain 9, non-muscle 0.0227465
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0226725
VEGFA vascular endothelial growth factor A 0.0224319
KIF16B kinesin family member 16B 0.0223065
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0221787
NKD1 naked cuticle homolog 1 (Drosophila) 0.0218704
NCEH1 neutral cholesterol ester hydrolase 1 0.0217359
MAML2 mastermind-like 2 (Drosophila) 0.0216472
PADI1 peptidyl arginine deiminase, type I 0.0213765
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0213445
NFE2L1 nuclear factor, erythroid 2-like 1 0.0213189
ERBIN erbb2 interacting protein 0.0212742
MCL1 myeloid cell leukemia 1 0.0211782
MCTP2 multiple C2 domains, transmembrane 2 0.0211386
TUT7 terminal uridylyl transferase 7 0.0211082
TRIM2 tripartite motif containing 2 0.0210545
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0210356
WEE1 WEE1 G2 checkpoint kinase 0.0210213
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0208172
SPATA13 spermatogenesis associated 13 0.020789
NPSR1 neuropeptide S receptor 1 0.0207251
TRIO trio Rho guanine nucleotide exchange factor 0.0205301
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0205228
ZFC3H1 zinc finger, C3H1-type containing 0.0204241
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0202216
COG3 component of oligomeric golgi complex 3 0.0201489
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0199219
ZSWIM6 zinc finger, SWIM-type containing 6 0.0197203
AKAP13 A kinase (PRKA) anchor protein 13 0.0196175
EPHB2 EPH receptor B2 0.0195596
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0194132
KAZN kazrin, periplakin interacting protein 0.0192033
SUMF1 sulfatase modifying factor 1 0.0191406
ARHGAP5 Rho GTPase activating protein 5 0.0189932
MBNL2 muscleblind-like splicing regulator 2 0.0189215
STX18 syntaxin 18 0.0189067
ETV6 ets variant 6 0.0188527
EFNB2 ephrin-B2 0.0187008
RAB21 RAB21, member RAS oncogene family 0.0186683
LAMB3 laminin, beta 3 0.0186554
SQSTM1 sequestosome 1 0.0185443
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0184889
SLK STE20-like kinase 0.0184752
ADIPOR2 adiponectin receptor 2 0.0184602
FRK fyn-related Src family tyrosine kinase 0.0183341
LPP LIM domain containing preferred translocation partner in lipoma 0.0181667
FNDC3A fibronectin type III domain containing 3A 0.0181218
SMAD3 SMAD family member 3 0.0179909
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0179505
LONRF3 LON peptidase N-terminal domain and ring finger 3 0.017871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0178403
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0176321
NUP98 nucleoporin 98kDa 0.0176059
YEATS2 YEATS domain containing 2 0.0175111
APP amyloid beta (A4) precursor protein 0.0175029
CLTC clathrin, heavy chain (Hc) 0.0174838
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0173463
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0172874
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0171118
TACSTD2 tumor-associated calcium signal transducer 2 0.0170945
ECT2 epithelial cell transforming 2 0.0169489
SSBP3 single stranded DNA binding protein 3 0.0169175
PMM2 phosphomannomutase 2 0.0167987
GOLGA3 golgin A3 0.016747
CCDC146 coiled-coil domain containing 146 0.01667
KDM6A lysine (K)-specific demethylase 6A 0.0166546
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0165212
TTC17 tetratricopeptide repeat domain 17 0.0164693
JMJD1C jumonji domain containing 1C 0.0164685
GRK3 G protein-coupled receptor kinase 3 0.0164675
MARCHF6 membrane associated ring-CH-type finger 6 0.0163825
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0163482

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.241585
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.229196
TPT1 tumor protein, translationally-controlled 1 -0.116399
C6ORF132 chromosome 6 open reading frame 132 -0.103481
HLA-B major histocompatibility complex, class I, B -0.0904428
EGR1 early growth response 1 -0.0864495
LCN2 lipocalin 2 -0.0805207
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0798467
PTBP3 polypyrimidine tract binding protein 3 -0.0776775
NCKAP5 NCK-associated protein 5 -0.0771448
RPS6 ribosomal protein S6 -0.0761213
ZMYND8 zinc finger, MYND-type containing 8 -0.0744831
EIF1 eukaryotic translation initiation factor 1 -0.0727427
IFI6 interferon, alpha-inducible protein 6 -0.0724965
PKM pyruvate kinase, muscle -0.0680906
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0674396
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0631637
RPLP1 ribosomal protein, large, P1 -0.0626348
BTBD9 BTB (POZ) domain containing 9 -0.0624191
FTL ferritin, light polypeptide -0.0554222
IFI27 interferon, alpha-inducible protein 27 -0.0534356
TXNIP thioredoxin interacting protein -0.0527353
RPS19 ribosomal protein S19 -0.052288
CCNL1 cyclin L1 -0.0516734
CST3 cystatin C -0.0514056
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0508321
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0496917
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0491634
IRF1 interferon regulatory factor 1 -0.0487434
S100A10 S100 calcium binding protein A10 -0.0480661
RPL23 ribosomal protein L23 -0.0477506
ITGA6 integrin, alpha 6 -0.0463706
RHOBTB3 Rho-related BTB domain containing 3 -0.0452839
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0444824
RUNX1 runt-related transcription factor 1 -0.0425446
MT2A metallothionein 2A -0.0411834
RPL28 ribosomal protein L28 -0.0410809
PERP PERP, TP53 apoptosis effector -0.0408541
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0407289
NAMPT nicotinamide phosphoribosyltransferase -0.0396411
RPLP2 ribosomal protein, large, P2 -0.0396038
RPL12 ribosomal protein L12 -0.0393072
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0392229
TMEM123 transmembrane protein 123 -0.0377547
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0371818
CSTB cystatin B (stefin B) -0.0369545
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0364446
DSTN destrin (actin depolymerizing factor) -0.035817
PDIA3 protein disulfide isomerase family A, member 3 -0.0356542
IFNGR1 interferon gamma receptor 1 -0.0354658
LOC112694756 uncharaterized LOC112694756 -0.035173
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0351265
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0342131
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0335175
RPS8 ribosomal protein S8 -0.0334698
RPS27 ribosomal protein S27 -0.0333132
MX2 MX dynamin-like GTPase 2 -0.0332155
TPI1 triosephosphate isomerase 1 -0.0332033
TMSB10 thymosin beta 10 -0.0330576
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0330505
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0326402
UBC ubiquitin C -0.0325794
NDRG1 N-myc downstream regulated 1 -0.032554
ABLIM1 actin binding LIM protein 1 -0.0320344
TXNRD1 thioredoxin reductase 1 -0.0319259
RPL19 ribosomal protein L19 -0.0319138
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0312374
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.031219
CDCP1 CUB domain containing protein 1 -0.0309806
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0307141
IFITM3 interferon induced transmembrane protein 3 -0.0303966
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0300536
GNAS GNAS complex locus -0.0296423
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0295498
TMEM165 transmembrane protein 165 -0.0294061
NPEPPS aminopeptidase puromycin sensitive -0.0293076
NRIP1 nuclear receptor interacting protein 1 -0.0292366
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0287517
RPL32 ribosomal protein L32 -0.0285638
KDM5A lysine (K)-specific demethylase 5A -0.0281106
WSB1 WD repeat and SOCS box containing 1 -0.0280285
MKI67 marker of proliferation Ki-67 -0.028017
LOC102724023 ES1 protein homolog, mitochondrial -0.0278586
RPL36 ribosomal protein L36 -0.0278375
SFTPA2 surfactant protein A2 -0.0276118
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0275732
MT1X metallothionein 1X -0.0275727
BPTF bromodomain PHD finger transcription factor -0.0274924
RPL35A ribosomal protein L35a -0.026924
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0268898
MTDH metadherin -0.0265662
NUCB2 nucleobindin 2 -0.0265602
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0264852
RPL36A ribosomal protein L36a -0.0263619
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0261416
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0257333
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0256236
UBE2B ubiquitin-conjugating enzyme E2B -0.0255599
HLA-C major histocompatibility complex, class I, C -0.0255265
SERF2 small EDRK-rich factor 2 -0.0254928