Baicalin_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.28408
SPTBN1 spectrin, beta, non-erythrocytic 1 0.122765
C3 complement component 3 0.109614
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.10832
SVIL supervillin 0.0931541
VEGFA vascular endothelial growth factor A 0.09151
EEF2 eukaryotic translation elongation factor 2 0.0844184
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0803184
DSPP dentin sialophosphoprotein 0.0778572
TNS1 tensin 1 0.0737882
FNDC3B fibronectin type III domain containing 3B 0.0609967
PEG3 paternally expressed 3 0.059196
FN1 fibronectin 1 0.0584821
PCBP2 poly(rC) binding protein 2 0.0574631
APLP2 amyloid beta (A4) precursor-like protein 2 0.0559185
NDRG1 N-myc downstream regulated 1 0.0495892
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0446699
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0441366
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0436872
EPAS1 endothelial PAS domain protein 1 0.0416343
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0408582
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0405846
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0396828
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0387399
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0380683
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.037055
SAMD4A sterile alpha motif domain containing 4A 0.0365997
CRY1 cryptochrome circadian clock 1 0.0361454
RPL3 ribosomal protein L3 0.0358983
NFE2L1 nuclear factor, erythroid 2-like 1 0.0354594
MYH9 myosin, heavy chain 9, non-muscle 0.0351546
DDIT4 DNA-damage-inducible transcript 4 0.0349839
RUNX1 runt-related transcription factor 1 0.0328531
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0327455
BHLHE40 basic helix-loop-helix family, member e40 0.0325817
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0305323
DOCK5 dedicator of cytokinesis 5 0.0303516
MBNL2 muscleblind-like splicing regulator 2 0.0302216
SMAD3 SMAD family member 3 0.0299791
HOOK2 hook microtubule-tethering protein 2 0.0288444
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0288231
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0287216
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.028636
MCL1 myeloid cell leukemia 1 0.0284708
INSIG2 insulin induced gene 2 0.0283212
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0282407
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0278172
FAM13A family with sequence similarity 13, member A 0.0277503
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.027704
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0268203
CEP250 centrosomal protein 250kDa 0.0266213
IGFBP1 insulin-like growth factor binding protein 1 0.0265907
TGFBI transforming growth factor, beta-induced, 68kDa 0.0259965
ELL2 elongation factor, RNA polymerase II, 2 0.024485
AKAP13 A kinase (PRKA) anchor protein 13 0.0244407
ARRDC3 arrestin domain containing 3 0.0243904
JMJD1C jumonji domain containing 1C 0.0243734
PER2 period circadian clock 2 0.0243347
AFDN afadin, adherens junction formation factor 0.0242266
MACF1 microtubule-actin crosslinking factor 1 0.0238356
GRB10 growth factor receptor-bound protein 10 0.0235632
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0230738
TXNRD1 thioredoxin reductase 1 0.0227673
USP6NL USP6 N-terminal like 0.0221575
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.022098
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0218257
NCKAP1 NCK-associated protein 1 0.0217842
AHR aryl hydrocarbon receptor 0.0217809
ERRFI1 ERBB receptor feedback inhibitor 1 0.0217191
RICTOR RPTOR independent companion of MTOR, complex 2 0.0217074
HELZ helicase with zinc finger 0.021416
MBNL1 muscleblind-like splicing regulator 1 0.021378
TBC1D22A TBC1 domain family, member 22A 0.0206641
MYO1B myosin IB 0.0206022
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0205958
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0203917
WWC2 WW and C2 domain containing 2 0.0203338
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0203115
PLEC plectin 0.0202906
ARFGEF3 ARFGEF family member 3 0.0200942
UBA6 ubiquitin-like modifier activating enzyme 6 0.0199592
ESYT2 extended synaptotagmin-like protein 2 0.0195917
SOX9 SRY (sex determining region Y)-box 9 0.0195472
TMX4 thioredoxin-related transmembrane protein 4 0.019391
EIF4B eukaryotic translation initiation factor 4B 0.0193909
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0193572
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0189696
DTNA dystrobrevin, alpha 0.0188712
DSCAM Down syndrome cell adhesion molecule 0.0188526
TNIP1 TNFAIP3 interacting protein 1 0.0185688
JAK1 Janus kinase 1 0.0183185
FLNB filamin B, beta 0.0182565
FBXO42 F-box protein 42 0.018137
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0180892
ZNF638 zinc finger protein 638 0.0177813
DOCK4 dedicator of cytokinesis 4 0.0177498
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0176252
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0176187
OPTN optineurin 0.0176089
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0175123

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.354756
TPT1 tumor protein, translationally-controlled 1 -0.189521
APOA2 apolipoprotein A-II -0.162154
MT2A metallothionein 2A -0.113217
TMSB10 thymosin beta 10 -0.112812
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11212
RPS24 ribosomal protein S24 -0.105589
GPC3 glypican 3 -0.0942147
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0922779
AKAP12 A kinase (PRKA) anchor protein 12 -0.0913699
RPS6 ribosomal protein S6 -0.0713136
RPL11 ribosomal protein L11 -0.0707657
TM4SF1 transmembrane 4 L six family member 1 -0.0689336
RPL23 ribosomal protein L23 -0.0630019
FTL ferritin, light polypeptide -0.0623921
RPS21 ribosomal protein S21 -0.0623715
SLC38A2 solute carrier family 38, member 2 -0.0603169
RPS8 ribosomal protein S8 -0.0603071
HMGA1 high mobility group AT-hook 1 -0.0590129
RPL34 ribosomal protein L34 -0.0569691
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0569101
ENO1 enolase 1, (alpha) -0.0560345
VCL vinculin -0.0559943
RPS19 ribosomal protein S19 -0.0555253
GNAS GNAS complex locus -0.0517161
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0516092
RPL35A ribosomal protein L35a -0.050466
RPS27A ribosomal protein S27a -0.0484598
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0481123
RPLP1 ribosomal protein, large, P1 -0.047335
APOE apolipoprotein E -0.0470234
ACTG1 actin gamma 1 -0.0465154
RPL37A ribosomal protein L37a -0.0461911
RPLP2 ribosomal protein, large, P2 -0.0461322
CP ceruloplasmin (ferroxidase) -0.0460719
ZBTB20 zinc finger and BTB domain containing 20 -0.0448816
GPC6 glypican 6 -0.0442968
RPL31 ribosomal protein L31 -0.0441127
RPL12 ribosomal protein L12 -0.0439966
AMBP alpha-1-microglobulin/bikunin precursor -0.0437052
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0416251
PTCHD4 patched domain containing 4 -0.0414509
ITGAV integrin, alpha V -0.0405751
RPS14 ribosomal protein S14 -0.0401585
RPS23 ribosomal protein S23 -0.0386211
RPS29 ribosomal protein S29 -0.0380812
ISG15 ISG15 ubiquitin-like modifier -0.037972
RPS13 ribosomal protein S13 -0.0376911
NPR2 natriuretic peptide receptor 2 -0.0372213
TMEM123 transmembrane protein 123 -0.0371129
IFI6 interferon, alpha-inducible protein 6 -0.0363908
H1-0 H1.0 linker histone -0.0363333
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0362886
RPL9 ribosomal protein L9 -0.0361785
PTMA prothymosin, alpha -0.0359293
RPLP0 ribosomal protein, large, P0 -0.035904
RPS16 ribosomal protein S16 -0.0357286
ATXN1 ataxin 1 -0.0352719
RPL26 ribosomal protein L26 -0.0352036
GMDS GDP-mannose 4,6-dehydratase -0.0346958
AHSG alpha-2-HS-glycoprotein -0.034407
RPS10 ribosomal protein S10 -0.0341592
IFITM1 interferon induced transmembrane protein 1 -0.0337825
RPL38 ribosomal protein L38 -0.0323164
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.03204
STAU1 staufen double-stranded RNA binding protein 1 -0.0318712
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0316636
RPS25 ribosomal protein S25 -0.031518
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0304511
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0302744
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0299768
NPAS2 neuronal PAS domain protein 2 -0.0293487
SOX5 SRY (sex determining region Y)-box 5 -0.0290314
PTPRK protein tyrosine phosphatase, receptor type, K -0.028875
ETFB electron-transfer-flavoprotein, beta polypeptide -0.028845
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0288035
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0287415
EXT1 exostosin glycosyltransferase 1 -0.0287016
LYZ lysozyme -0.0285044
RACK1 receptor for activated C kinase 1 -0.0283665
PERP PERP, TP53 apoptosis effector -0.0283003
EGR1 early growth response 1 -0.0278163
DLC1 DLC1 Rho GTPase activating protein -0.0276536
RPL28 ribosomal protein L28 -0.0273803
RPL19 ribosomal protein L19 -0.0271521
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0267848
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0265621
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0261612
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0260402
MX2 MX dynamin-like GTPase 2 -0.0258551
RPL32 ribosomal protein L32 -0.0258049
GCC2 GRIP and coiled-coil domain containing 2 -0.0255355
RPS5 ribosomal protein S5 -0.0252734
RAB1A RAB1A, member RAS oncogene family -0.0251514
MYL12B myosin, light chain 12B, regulatory -0.0250848
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0250766
EIF1 eukaryotic translation initiation factor 1 -0.0250487
EHBP1 EH domain binding protein 1 -0.0249132
RRBP1 ribosome binding protein 1 -0.0247721
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0247017