Baicalin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PALM2AKAP2 PALM2 and AKAP2 fusion 0.11378
LMO7 LIM domain 7 0.102979
MTSS1 metastasis suppressor 1 0.0838403
SLC35F3 solute carrier family 35, member F3 0.0800851
BCAR3 breast cancer anti-estrogen resistance 3 0.0764107
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0690331
PDE4D phosphodiesterase 4D, cAMP-specific 0.0687365
PDLIM5 PDZ and LIM domain 5 0.0619031
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0584668
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0577584
PODXL podocalyxin-like 0.0544288
MACF1 microtubule-actin crosslinking factor 1 0.0521297
PLEC plectin 0.051869
DPYD dihydropyrimidine dehydrogenase 0.0502626
MPRIP myosin phosphatase Rho interacting protein 0.0492555
RASAL2 RAS protein activator like 2 0.0483982
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0478169
FOXO1 forkhead box O1 0.047043
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0448666
AKAP13 A kinase (PRKA) anchor protein 13 0.0439791
MSN moesin 0.0426505
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0417866
PSD3 pleckstrin and Sec7 domain containing 3 0.0416475
GRB10 growth factor receptor-bound protein 10 0.0396845
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0393404
LAMA5 laminin, alpha 5 0.0389795
RAI14 retinoic acid induced 14 0.0379544
RABGAP1L RAB GTPase activating protein 1-like 0.03728
ANO1 anoctamin 1, calcium activated chloride channel 0.0371982
RNF217 ring finger protein 217 0.0368219
HMGA2 high mobility group AT-hook 2 0.0363306
RCOR1 REST corepressor 1 0.0357526
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0344726
INTS6 integrator complex subunit 6 0.0343725
PTK2 protein tyrosine kinase 2 0.0337359
THSD4 thrombospondin, type I, domain containing 4 0.0333731
SULF2 sulfatase 2 0.0333377
HSPG2 heparan sulfate proteoglycan 2 0.0327649
LAMC2 laminin, gamma 2 0.0325474
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0322622
TRIO trio Rho guanine nucleotide exchange factor 0.0321676
ZSWIM6 zinc finger, SWIM-type containing 6 0.0321291
KIAA1671 KIAA1671 0.032116
DPYSL2 dihydropyrimidinase-like 2 0.0320031
EFNA5 ephrin-A5 0.031915
MYH9 myosin, heavy chain 9, non-muscle 0.0312262
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0295264
NRIP1 nuclear receptor interacting protein 1 0.0292644
AOPEP aminopeptidase O (putative) 0.0290236
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0289848
FRMD6 FERM domain containing 6 0.028898
VCL vinculin 0.0286031
DOCK5 dedicator of cytokinesis 5 0.0281852
LPP LIM domain containing preferred translocation partner in lipoma 0.0280623
MECOM MDS1 and EVI1 complex locus 0.0279887
LUZP1 leucine zipper protein 1 0.0276836
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0274342
ZMIZ1 zinc finger, MIZ-type containing 1 0.0272251
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.027192
AMOTL1 angiomotin like 1 0.0271896
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0271095
ACTN1 actinin, alpha 1 0.026999
DST dystonin 0.0267213
PLS3 plastin 3 0.0263943
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261458
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0251699
CDK6 cyclin-dependent kinase 6 0.0250731
RAD51B RAD51 paralog B 0.0249612
MYOF myoferlin 0.0249236
KLF12 Kruppel-like factor 12 0.0248122
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0245592
PYGL phosphorylase, glycogen, liver 0.0244438
NAV2 neuron navigator 2 0.0243787
SMAD3 SMAD family member 3 0.0239227
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0238502
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0236484
ITGB4 integrin, beta 4 0.0235617
EXOC4 exocyst complex component 4 0.023301
GRK5 G protein-coupled receptor kinase 5 0.0230742
EXT1 exostosin glycosyltransferase 1 0.0230059
MEGF6 multiple EGF-like-domains 6 0.0228706
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0225557
DOCK4 dedicator of cytokinesis 4 0.0225287
EGFR epidermal growth factor receptor 0.022382
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.022307
PLXNA2 plexin A2 0.0222623
SMYD3 SET and MYND domain containing 3 0.0216213
DGKH diacylglycerol kinase, eta 0.0215477
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0213741
ABLIM3 actin binding LIM protein family, member 3 0.0212068
IRAK2 interleukin-1 receptor-associated kinase 2 0.020653
FNDC3B fibronectin type III domain containing 3B 0.0205291
CSMD2 CUB and Sushi multiple domains 2 0.0202542
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0202302
MEF2A myocyte enhancer factor 2A 0.0201122
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0200495
TSC22D1 TSC22 domain family, member 1 0.0200076
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0198341
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.019679
SPIRE1 spire-type actin nucleation factor 1 0.0196217

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143011
PTMA prothymosin, alpha -0.123715
ENO1 enolase 1, (alpha) -0.123703
B2M beta-2-microglobulin -0.122978
TPT1 tumor protein, translationally-controlled 1 -0.103538
TMSB10 thymosin beta 10 -0.0936152
CLU clusterin -0.0876729
KRT17 keratin 17, type I -0.084422
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0767649
UBC ubiquitin C -0.0764628
RPS8 ribosomal protein S8 -0.0764018
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.075831
RPS21 ribosomal protein S21 -0.0712466
HLA-B major histocompatibility complex, class I, B -0.0710043
NAMPT nicotinamide phosphoribosyltransferase -0.0709529
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0646916
S100A10 S100 calcium binding protein A10 -0.0639672
RPS27A ribosomal protein S27a -0.0635601
EMP1 epithelial membrane protein 1 -0.0629344
TMSB4X thymosin beta 4, X-linked -0.0619489
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0589213
LMNA lamin A/C -0.05871
GOLGA4 golgin A4 -0.0557201
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0526803
RPL11 ribosomal protein L11 -0.0522614
PGK1 phosphoglycerate kinase 1 -0.0518843
CANX calnexin -0.0514368
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0496941
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0492515
RPLP2 ribosomal protein, large, P2 -0.0489766
LDHA lactate dehydrogenase A -0.0489562
GNAS GNAS complex locus -0.0487112
IFITM3 interferon induced transmembrane protein 3 -0.0482534
RPS13 ribosomal protein S13 -0.04716
MT2A metallothionein 2A -0.0466949
RPL12 ribosomal protein L12 -0.0465975
RPLP1 ribosomal protein, large, P1 -0.0465844
RPS24 ribosomal protein S24 -0.0460583
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0455081
IGF2 insulin-like growth factor 2 -0.0453631
RPL23 ribosomal protein L23 -0.0451207
S100A6 S100 calcium binding protein A6 -0.0443274
IFITM1 interferon induced transmembrane protein 1 -0.04346
RPS3 ribosomal protein S3 -0.0420706
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0420409
IFI16 interferon, gamma-inducible protein 16 -0.0416444
PRRC2C proline-rich coiled-coil 2C -0.0415058
NAP1L1 nucleosome assembly protein 1-like 1 -0.0412278
CALU calumenin -0.0400199
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0398829
ANXA1 annexin A1 -0.0383167
RBM39 RNA binding motif protein 39 -0.0379236
EIF1 eukaryotic translation initiation factor 1 -0.0378604
DSTN destrin (actin depolymerizing factor) -0.0376053
POTEF POTE ankyrin domain family, member F -0.0374505
RPL26 ribosomal protein L26 -0.0369228
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0368468
AHNAK AHNAK nucleoprotein -0.0368424
SERINC3 serine incorporator 3 -0.0364762
H1-0 H1.0 linker histone -0.0358822
LOC112694756 uncharaterized LOC112694756 -0.0356661
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0351675
MORF4L2 mortality factor 4 like 2 -0.0348731
RPS6 ribosomal protein S6 -0.0344069
NDRG1 N-myc downstream regulated 1 -0.0342401
RPS25 ribosomal protein S25 -0.0340976
KDM3A lysine (K)-specific demethylase 3A -0.0340823
RPL34 ribosomal protein L34 -0.0339828
RPS19 ribosomal protein S19 -0.0339002
RPL31 ribosomal protein L31 -0.0336025
CALR calreticulin -0.0329983
S100A2 S100 calcium binding protein A2 -0.0326129
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0324956
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.032364
RPS12 ribosomal protein S12 -0.0322756
KTN1 kinectin 1 (kinesin receptor) -0.0320992
TXNIP thioredoxin interacting protein -0.0320107
S100A11 S100 calcium binding protein A11 -0.0318368
RPLP0 ribosomal protein, large, P0 -0.0318008
FTL ferritin, light polypeptide -0.0317908
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0314935
VDAC1 voltage-dependent anion channel 1 -0.0306787
S100A9 S100 calcium binding protein A9 -0.0304298
WSB1 WD repeat and SOCS box containing 1 -0.0300346
MARCHF6 membrane associated ring-CH-type finger 6 -0.0299759
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0297604
OGA O-GlcNAcase -0.0296336
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0294595
HLA-A major histocompatibility complex, class I, A -0.0294096
TM4SF1 transmembrane 4 L six family member 1 -0.02935
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0291541
RPL5 ribosomal protein L5 -0.0286316
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0285946
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0283095
RPL9 ribosomal protein L9 -0.0281539
RPL7A ribosomal protein L7a -0.0281326
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0278172
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0278103
CAV1 caveolin 1, caveolae protein, 22kDa -0.0277573
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0276673