Baicalin_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0905979
MBNL2 muscleblind-like splicing regulator 2 0.0746651
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0725938
PDIA3 protein disulfide isomerase family A, member 3 0.0689038
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0675786
GOLGA4 golgin A4 0.0661504
FTH1 ferritin, heavy polypeptide 1 0.065902
FNDC3B fibronectin type III domain containing 3B 0.0646096
LMO7 LIM domain 7 0.0606882
HYOU1 hypoxia up-regulated 1 0.0568521
MYH9 myosin, heavy chain 9, non-muscle 0.0547942
MAML2 mastermind-like 2 (Drosophila) 0.0514781
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0505003
PCBP2 poly(rC) binding protein 2 0.0480219
ITGA6 integrin, alpha 6 0.0462476
TNIK TRAF2 and NCK interacting kinase 0.041185
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0410079
IARS1 isoleucyl-tRNA synthetase 1 0.0409105
ZCCHC7 zinc finger, CCHC domain containing 7 0.0400818
KLHL29 kelch-like family member 29 0.0396544
ADAM9 ADAM metallopeptidase domain 9 0.038878
PLEC plectin 0.0384514
CEMIP cell migration inducing protein, hyaluronan binding 0.0372961
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0366014
AKAP13 A kinase (PRKA) anchor protein 13 0.0353193
PDIA6 protein disulfide isomerase family A, member 6 0.0341686
VMP1 vacuole membrane protein 1 0.0341164
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0331483
FLNB filamin B, beta 0.0326214
NCOR2 nuclear receptor corepressor 2 0.0317012
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.031555
FGFR2 fibroblast growth factor receptor 2 0.0315344
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0310365
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0310267
APLP2 amyloid beta (A4) precursor-like protein 2 0.0308587
POTEF POTE ankyrin domain family, member F 0.0306324
FAM13A family with sequence similarity 13, member A 0.0303515
MYOF myoferlin 0.0301539
TPM3 tropomyosin 3 0.0294333
ANXA1 annexin A1 0.028368
ARHGAP32 Rho GTPase activating protein 32 0.028137
NFE2L1 nuclear factor, erythroid 2-like 1 0.0274439
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.026674
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0261064
AKAP9 A kinase (PRKA) anchor protein 9 0.0260118
MYO5B myosin VB 0.0259961
DSPP dentin sialophosphoprotein 0.0255916
ITCH itchy E3 ubiquitin protein ligase 0.0254999
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0253251
SNX13 sorting nexin 13 0.0249381
NDRG1 N-myc downstream regulated 1 0.0248452
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0247339
ARHGAP26 Rho GTPase activating protein 26 0.0247082
GRB10 growth factor receptor-bound protein 10 0.0245554
KDM2A lysine (K)-specific demethylase 2A 0.0245283
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0238782
MACF1 microtubule-actin crosslinking factor 1 0.0238463
UBA6 ubiquitin-like modifier activating enzyme 6 0.023685
PGM3 phosphoglucomutase 3 0.0236683
SETD5 SET domain containing 5 0.0233915
SEC31A SEC31 homolog A (S. cerevisiae) 0.0233773
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0232121
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0230961
PICALM phosphatidylinositol binding clathrin assembly protein 0.0229898
HELZ helicase with zinc finger 0.022876
ITGB4 integrin, beta 4 0.0228213
MCU mitochondrial calcium uniporter 0.0227425
TRAM1 translocation associated membrane protein 1 0.0224736
COPA coatomer protein complex, subunit alpha 0.022221
KMT2E lysine (K)-specific methyltransferase 2E 0.0219685
HM13 histocompatibility (minor) 13 0.0217383
SLTM SAFB-like, transcription modulator 0.0216232
SLK STE20-like kinase 0.0215899
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0214662
HKDC1 hexokinase domain containing 1 0.0214267
EEF2 eukaryotic translation elongation factor 2 0.0212984
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0212604
COG5 component of oligomeric golgi complex 5 0.0211811
ESYT2 extended synaptotagmin-like protein 2 0.0209754
SRP54 signal recognition particle 54kDa 0.0208973
TMF1 TATA element modulatory factor 1 0.0208656
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0208502
PMM2 phosphomannomutase 2 0.0206543
TRAK1 trafficking protein, kinesin binding 1 0.0204105
TES testin LIM domain protein 0.020289
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0202218
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.020084
BIRC6 baculoviral IAP repeat containing 6 0.0200737
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0197538
AGR3 anterior gradient 3 0.0196939
TTC3 tetratricopeptide repeat domain 3 0.0195804
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0193985
CCNY cyclin Y 0.0193797
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0193116
EIF4A2 eukaryotic translation initiation factor 4A2 0.01919
CLTC clathrin, heavy chain (Hc) 0.0191101
KIF16B kinesin family member 16B 0.0191058
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0190695
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0190564
EPS8 epidermal growth factor receptor pathway substrate 8 0.019043

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.205856
TPT1 tumor protein, translationally-controlled 1 -0.173049
PTMA prothymosin, alpha -0.126892
RPL35A ribosomal protein L35a -0.112424
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107289
RPL23 ribosomal protein L23 -0.103585
RPS19 ribosomal protein S19 -0.0944424
RPLP1 ribosomal protein, large, P1 -0.0928502
FTL ferritin, light polypeptide -0.074309
EIF1 eukaryotic translation initiation factor 1 -0.0729995
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0690673
B2M beta-2-microglobulin -0.0681322
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0663894
RPL19 ribosomal protein L19 -0.0659476
S100A9 S100 calcium binding protein A9 -0.0652865
RPS21 ribosomal protein S21 -0.0649853
RPS24 ribosomal protein S24 -0.0644179
RPL26 ribosomal protein L26 -0.0639613
RPS6 ribosomal protein S6 -0.0637452
S100A10 S100 calcium binding protein A10 -0.0636009
RPS8 ribosomal protein S8 -0.0625284
RPS25 ribosomal protein S25 -0.0607177
IFI27 interferon, alpha-inducible protein 27 -0.059406
S100P S100 calcium binding protein P -0.0579747
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0573645
ACTG1 actin gamma 1 -0.0555651
EPCAM epithelial cell adhesion molecule -0.0533842
RPL38 ribosomal protein L38 -0.0527983
RPL34 ribosomal protein L34 -0.0527712
RPL12 ribosomal protein L12 -0.0523595
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0519162
RPS29 ribosomal protein S29 -0.0488939
RRBP1 ribosome binding protein 1 -0.0484555
RPS3 ribosomal protein S3 -0.0480742
RPL32 ribosomal protein L32 -0.046805
RPLP2 ribosomal protein, large, P2 -0.0452975
RPL9 ribosomal protein L9 -0.0445292
NDUFA4 NDUFA4, mitochondrial complex associated -0.0429383
TM4SF1 transmembrane 4 L six family member 1 -0.0423975
ATF5 activating transcription factor 5 -0.0423733
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0422899
RPL28 ribosomal protein L28 -0.0421661
MYL12B myosin, light chain 12B, regulatory -0.0416688
RPS27A ribosomal protein S27a -0.041394
RPL36A ribosomal protein L36a -0.0403668
IFI6 interferon, alpha-inducible protein 6 -0.0403584
RPL7A ribosomal protein L7a -0.039651
HLA-E major histocompatibility complex, class I, E -0.0395787
RPL27 ribosomal protein L27 -0.0394401
RPL35 ribosomal protein L35 -0.0388039
H3-3B H3.3 histone B -0.0386282
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0383586
RPL37A ribosomal protein L37a -0.0373494
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.036749
RPL11 ribosomal protein L11 -0.0366411
RPL36 ribosomal protein L36 -0.0363955
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0363478
HLA-C major histocompatibility complex, class I, C -0.0359356
SEC61G Sec61 gamma subunit -0.0352803
HLA-B major histocompatibility complex, class I, B -0.0352155
GSTP1 glutathione S-transferase pi 1 -0.0331593
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0321741
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0320342
RPS23 ribosomal protein S23 -0.0309806
TUBB4B tubulin, beta 4B class IVb -0.030957
SERF2 small EDRK-rich factor 2 -0.0307946
RPS16 ribosomal protein S16 -0.0306193
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0302292
RPS5 ribosomal protein S5 -0.0295688
KLF6 Kruppel-like factor 6 -0.0294013
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0291473
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0291236
LMNA lamin A/C -0.028984
RPL5 ribosomal protein L5 -0.0288233
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.02873
RPL31 ribosomal protein L31 -0.0287218
EMP1 epithelial membrane protein 1 -0.0287043
RPS15 ribosomal protein S15 -0.0284289
RPS27 ribosomal protein S27 -0.0283893
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.028358
IFITM3 interferon induced transmembrane protein 3 -0.0282426
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0282178
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0277728
ATP5F1E ATP synthase F1 subunit epsilon -0.0275816
RPS10 ribosomal protein S10 -0.0274239
SELENOK selenoprotein K -0.0273613
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0269597
GNAS GNAS complex locus -0.0269485
HMGB1 high mobility group box 1 -0.0268469
KRT8 keratin 8, type II -0.0268277
AGR2 anterior gradient 2 -0.0266961
RPL36AL ribosomal protein L36a-like -0.0265214
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0263328
IFITM1 interferon induced transmembrane protein 1 -0.0256029
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0255926
H1-0 H1.0 linker histone -0.0253951
RPS11 ribosomal protein S11 -0.0252451
RPL30 ribosomal protein L30 -0.025141
UBB ubiquitin B -0.0250938
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.024914