Baicalin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.172453
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.151312
LMO7 LIM domain 7 0.100026
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0754581
RNF145 ring finger protein 145 0.0461668
MACF1 microtubule-actin crosslinking factor 1 0.0446499
NDRG1 N-myc downstream regulated 1 0.0424515
FAT1 FAT atypical cadherin 1 0.041946
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0410266
EEF2 eukaryotic translation elongation factor 2 0.0394587
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0392031
MYH9 myosin, heavy chain 9, non-muscle 0.0375997
EREG epiregulin 0.0363339
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0355669
CEMIP2 cell migration inducing hyaluronidase 2 0.0353279
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0343766
GOLGA4 golgin A4 0.0342593
MED13L mediator complex subunit 13-like 0.0337179
TXNIP thioredoxin interacting protein 0.032103
OGA O-GlcNAcase 0.03143
ONECUT3 one cut homeobox 3 0.0312153
PDIA4 protein disulfide isomerase family A, member 4 0.0301733
CANX calnexin 0.0300555
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0299405
WAC WW domain containing adaptor with coiled-coil 0.0295525
KLF5 Kruppel-like factor 5 (intestinal) 0.028661
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0281368
FAM13A family with sequence similarity 13, member A 0.0278751
CEMIP cell migration inducing protein, hyaluronan binding 0.027869
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0277232
EXT1 exostosin glycosyltransferase 1 0.027638
DSCAM Down syndrome cell adhesion molecule 0.0271428
ZFAND3 zinc finger, AN1-type domain 3 0.0268557
RBM39 RNA binding motif protein 39 0.0268121
GARS1 glycyl-tRNA synthetase 1 0.0266651
AREG amphiregulin 0.0266189
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0263308
MUC13 mucin 13, cell surface associated 0.0262971
MYO5B myosin VB 0.0261757
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0261511
SHROOM3 shroom family member 3 0.0257168
COPA coatomer protein complex, subunit alpha 0.0256763
CTNND1 catenin (cadherin-associated protein), delta 1 0.0254482
AFDN afadin, adherens junction formation factor 0.0253796
RNF43 ring finger protein 43 0.0247698
KMT2E lysine (K)-specific methyltransferase 2E 0.0246957
KDM3A lysine (K)-specific demethylase 3A 0.0244857
CALR calreticulin 0.0243113
YTHDC1 YTH domain containing 1 0.024035
DSPP dentin sialophosphoprotein 0.0239224
SOX9 SRY (sex determining region Y)-box 9 0.0238083
IARS1 isoleucyl-tRNA synthetase 1 0.0237622
PCBP2 poly(rC) binding protein 2 0.0235901
UBE2H ubiquitin-conjugating enzyme E2H 0.0235623
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0233
MBNL2 muscleblind-like splicing regulator 2 0.0232173
TFG TRK-fused gene 0.0230004
USP9X ubiquitin specific peptidase 9, X-linked 0.0226361
ANKRD11 ankyrin repeat domain 11 0.0224066
EPS8 epidermal growth factor receptor pathway substrate 8 0.0224043
ERRFI1 ERBB receptor feedback inhibitor 1 0.0221757
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0217037
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0216165
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0215865
SEC31A SEC31 homolog A (S. cerevisiae) 0.0214896
NEBL nebulette 0.021312
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0212311
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.021125
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0210852
GDF15 growth differentiation factor 15 0.0210417
HSPA8 heat shock 70kDa protein 8 0.0206778
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.020658
SPRED2 sprouty-related, EVH1 domain containing 2 0.0205215
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0204389
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0201236
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0197952
RAB1A RAB1A, member RAS oncogene family 0.0197851
PLEC plectin 0.0195705
MARCHF6 membrane associated ring-CH-type finger 6 0.0194656
HDLBP high density lipoprotein binding protein 0.019397
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0193131
ITPRID2 ITPR interacting domain containing 2 0.0188987
CDC73 cell division cycle 73 0.0186715
COG5 component of oligomeric golgi complex 5 0.0186244
FOXO1 forkhead box O1 0.0186164
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0185687
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0182483
FHL2 four and a half LIM domains 2 0.018223
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0181337
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0181273
NUP58 nucleoporin 58 0.0181057
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0180098
MYO10 myosin X 0.0179215
USP3 ubiquitin specific peptidase 3 0.0178903
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0178422
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0177677
CUL3 cullin 3 0.0177671
TRA2A transformer 2 alpha homolog (Drosophila) 0.0175582
DUSP4 dual specificity phosphatase 4 0.0173619
USP6NL USP6 N-terminal like 0.0172983

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.232981
PTMA prothymosin, alpha -0.173344
TMSB10 thymosin beta 10 -0.16445
MUC6 mucin 6, oligomeric mucus/gel-forming -0.155499
TPT1 tumor protein, translationally-controlled 1 -0.117243
RPS6 ribosomal protein S6 -0.0992412
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0949206
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0910556
NALF1 NALCN channel auxiliary factor 1 -0.0910217
S100A6 S100 calcium binding protein A6 -0.0661331
ACTG1 actin gamma 1 -0.0650319
POTEF POTE ankyrin domain family, member F -0.0612687
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0582212
ALCAM activated leukocyte cell adhesion molecule -0.0543541
GREB1L growth regulation by estrogen in breast cancer-like -0.0534119
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0530906
RPL9 ribosomal protein L9 -0.0524128
RPL35A ribosomal protein L35a -0.0495801
RPS8 ribosomal protein S8 -0.0459025
MUC17 mucin 17, cell surface associated -0.0446546
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0424968
CALB1 calbindin 1, 28kDa -0.0423992
TFF1 trefoil factor 1 -0.0406869
TFF3 trefoil factor 3 (intestinal) -0.0395013
HMGA1 high mobility group AT-hook 1 -0.0390891
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.036732
RPS24 ribosomal protein S24 -0.0361699
RPS25 ribosomal protein S25 -0.035746
KRT18 keratin 18, type I -0.0347605
RNF217 ring finger protein 217 -0.034677
TUBA1B tubulin, alpha 1b -0.0345903
PTPRK protein tyrosine phosphatase, receptor type, K -0.0340795
RPLP2 ribosomal protein, large, P2 -0.0335359
SLC35F3 solute carrier family 35, member F3 -0.0333367
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0332166
GMDS GDP-mannose 4,6-dehydratase -0.0331361
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0331357
ANTXR2 anthrax toxin receptor 2 -0.0327526
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0326536
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0325167
KLK10 kallikrein-related peptidase 10 -0.0320024
RPL23 ribosomal protein L23 -0.0312098
RPLP1 ribosomal protein, large, P1 -0.0303841
PERP PERP, TP53 apoptosis effector -0.0297472
LMNA lamin A/C -0.0296988
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0296831
MAML2 mastermind-like 2 (Drosophila) -0.0296828
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.029557
RPS27A ribosomal protein S27a -0.029152
ATP5F1B ATP synthase F1 subunit beta -0.0287281
FHIT fragile histidine triad -0.0283117
RPL7A ribosomal protein L7a -0.0281823
GPHN gephyrin -0.0277289
RPS19 ribosomal protein S19 -0.0273438
PFN1 profilin 1 -0.0269649
FERMT1 fermitin family member 1 -0.0267652
SH3D19 SH3 domain containing 19 -0.0264552
SOX4 SRY (sex determining region Y)-box 4 -0.0263605
RPLP0 ribosomal protein, large, P0 -0.02635
RPS23 ribosomal protein S23 -0.026273
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.026135
DIAPH2 diaphanous-related formin 2 -0.0260066
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0257528
LSAMP limbic system-associated membrane protein -0.0256877
DEK DEK proto-oncogene -0.0256073
RPS14 ribosomal protein S14 -0.025555
SAMD5 sterile alpha motif domain containing 5 -0.0251192
TUBB4B tubulin, beta 4B class IVb -0.0251011
PDE4D phosphodiesterase 4D, cAMP-specific -0.0249981
ENO1 enolase 1, (alpha) -0.0249133
KRT19 keratin 19, type I -0.0247438
FOSL1 FOS-like antigen 1 -0.0243725
DLG1 discs, large homolog 1 (Drosophila) -0.0242556
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0241624
RPS21 ribosomal protein S21 -0.0240797
PKM pyruvate kinase, muscle -0.0240579
TPM4 tropomyosin 4 -0.0240236
GCC2 GRIP and coiled-coil domain containing 2 -0.0239509
RPL34 ribosomal protein L34 -0.0236826
TPI1 triosephosphate isomerase 1 -0.022805
RPL15 ribosomal protein L15 -0.0227383
RIN2 Ras and Rab interactor 2 -0.0226225
RPS16 ribosomal protein S16 -0.0224383
CBX3 chromobox homolog 3 -0.022417
RPL36A ribosomal protein L36a -0.0222375
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0221179
RPL12 ribosomal protein L12 -0.0218426
F3 coagulation factor III (thromboplastin, tissue factor) -0.0218205
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0217309
SERBP1 SERPINE1 mRNA binding protein 1 -0.0217111
HMGB1 high mobility group box 1 -0.0214532
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0214297
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0211938
RPS13 ribosomal protein S13 -0.0207655
SRPK1 SRSF protein kinase 1 -0.0205195
RPL8 ribosomal protein L8 -0.0204267
RPL37A ribosomal protein L37a -0.0201928
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0201196
RPS29 ribosomal protein S29 -0.0200153
RPL31 ribosomal protein L31 -0.0199152