Baicalin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.167935
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.161988
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.130152
SPAG9 sperm associated antigen 9 0.11324
CAPRIN2 caprin family member 2 0.0836877
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0758154
TMSB4X thymosin beta 4, X-linked 0.0669979
PTMA prothymosin, alpha 0.064043
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0640429
FMNL2 formin-like 2 0.0636117
VCL vinculin 0.0609019
RUNX1 runt-related transcription factor 1 0.0600848
BCAR3 breast cancer anti-estrogen resistance 3 0.0569825
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0542653
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0523849
RCOR1 REST corepressor 1 0.0518355
OGA O-GlcNAcase 0.0472823
WSB1 WD repeat and SOCS box containing 1 0.0459328
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0458752
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0447287
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0446538
CALR calreticulin 0.0433288
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0432897
TOP1 topoisomerase (DNA) I 0.0431709
WAC WW domain containing adaptor with coiled-coil 0.0420544
RPS12 ribosomal protein S12 0.0412606
ERRFI1 ERBB receptor feedback inhibitor 1 0.0408717
TXNIP thioredoxin interacting protein 0.0407815
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0406978
CD44 CD44 molecule (Indian blood group) 0.0405405
RAB7A RAB7A, member RAS oncogene family 0.0402171
TRA2A transformer 2 alpha homolog (Drosophila) 0.0397139
PUM2 pumilio RNA-binding family member 2 0.0393294
EZR ezrin 0.0392548
ZNF292 zinc finger protein 292 0.0392346
PRELID2 PRELI domain containing 2 0.0391515
KDM3A lysine (K)-specific demethylase 3A 0.0390707
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0389599
FXR1 fragile X mental retardation, autosomal homolog 1 0.0385699
SQSTM1 sequestosome 1 0.038403
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0383576
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0382539
PUM1 pumilio RNA-binding family member 1 0.0377284
APP amyloid beta (A4) precursor protein 0.0372086
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0368334
TSC22D2 TSC22 domain family, member 2 0.0365487
MYOF myoferlin 0.0361626
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0360517
DSCAM Down syndrome cell adhesion molecule 0.0358917
WWTR1 WW domain containing transcription regulator 1 0.0357238
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0355023
RBM39 RNA binding motif protein 39 0.0345961
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0341691
STRN3 striatin, calmodulin binding protein 3 0.033592
ZSWIM6 zinc finger, SWIM-type containing 6 0.0335475
STAG2 stromal antigen 2 0.03327
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.032917
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0326054
PIAS2 protein inhibitor of activated STAT, 2 0.0323643
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0321235
PLK2 polo-like kinase 2 0.0320201
FNIP1 folliculin interacting protein 1 0.0317405
CLIP2 CAP-GLY domain containing linker protein 2 0.0317376
NUP58 nucleoporin 58 0.0316395
GLS2 glutaminase 2 (liver, mitochondrial) 0.0315212
PDIA6 protein disulfide isomerase family A, member 6 0.031473
LPP LIM domain containing preferred translocation partner in lipoma 0.031432
MARCHF6 membrane associated ring-CH-type finger 6 0.0312147
TNS3 tensin 3 0.0311345
SMAD3 SMAD family member 3 0.0310897
ANKRD11 ankyrin repeat domain 11 0.0308274
CANX calnexin 0.0307991
QKI QKI, KH domain containing, RNA binding 0.0307136
VMP1 vacuole membrane protein 1 0.0306175
CAMTA1 calmodulin binding transcription activator 1 0.0303285
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0302194
HSPA8 heat shock 70kDa protein 8 0.0297214
TRIO trio Rho guanine nucleotide exchange factor 0.0296899
AFF4 AF4/FMR2 family, member 4 0.0296069
KLF6 Kruppel-like factor 6 0.0294779
ZFAND3 zinc finger, AN1-type domain 3 0.0293314
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0292856
TP63 tumor protein p63 0.029248
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0292352
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0291607
JMJD1C jumonji domain containing 1C 0.0291292
PCBP2 poly(rC) binding protein 2 0.0288845
SDC4 syndecan 4 0.0287028
CDC73 cell division cycle 73 0.0286172
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0283532
BZW1 basic leucine zipper and W2 domains 1 0.028351
HOOK2 hook microtubule-tethering protein 2 0.0283045
KMT2C lysine (K)-specific methyltransferase 2C 0.0279148
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0279067
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.027865
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0276225
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0274139
ACTN1 actinin, alpha 1 0.0272777
ZNF207 zinc finger protein 207 0.0271211
HELZ helicase with zinc finger 0.0270512

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.155327
VIM vimentin -0.148402
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109214
TXNRD1 thioredoxin reductase 1 -0.0896841
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0580327
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0526508
ZMYND8 zinc finger, MYND-type containing 8 -0.0465444
MT1E metallothionein 1E -0.0441242
POTEF POTE ankyrin domain family, member F -0.0410097
RAI1 retinoic acid induced 1 -0.0395514
HMGA1 high mobility group AT-hook 1 -0.0385788
SRGN serglycin -0.0356181
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0354322
RPS6 ribosomal protein S6 -0.0351551
ACTG1 actin gamma 1 -0.0348141
EMP1 epithelial membrane protein 1 -0.034778
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0335627
PRDX1 peroxiredoxin 1 -0.0334758
RPS23 ribosomal protein S23 -0.0330251
TM4SF1 transmembrane 4 L six family member 1 -0.0327778
UPP1 uridine phosphorylase 1 -0.0318843
NAV2 neuron navigator 2 -0.031808
MT1X metallothionein 1X -0.0309664
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0304338
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0295758
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0292229
ANXA1 annexin A1 -0.0290687
FTL ferritin, light polypeptide -0.0287669
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0278324
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0272593
RPLP2 ribosomal protein, large, P2 -0.02692
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0264021
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0263994
RPL7A ribosomal protein L7a -0.0257759
RPL31 ribosomal protein L31 -0.0248031
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0247532
GCLM glutamate-cysteine ligase, modifier subunit -0.024506
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0244599
USP34 ubiquitin specific peptidase 34 -0.0238165
RPL5 ribosomal protein L5 -0.02326
CDCP1 CUB domain containing protein 1 -0.0231464
RCAN1 regulator of calcineurin 1 -0.0231044
RPS19 ribosomal protein S19 -0.0222899
S100A11 S100 calcium binding protein A11 -0.0220315
ANGPTL4 angiopoietin-like 4 -0.022011
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0218826
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0205582
RPL23 ribosomal protein L23 -0.0204357
RPL28 ribosomal protein L28 -0.0202984
TAPBP TAP binding protein (tapasin) -0.0198602
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.019811
DLG1 discs, large homolog 1 (Drosophila) -0.0197747
VDAC1 voltage-dependent anion channel 1 -0.0192414
RPL27 ribosomal protein L27 -0.0191869
RPS24 ribosomal protein S24 -0.0190603
DARS1 aspartyl-tRNA synthetase 1 -0.0187826
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.018503
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0181445
RPS8 ribosomal protein S8 -0.0181439
CEP170 centrosomal protein 170kDa -0.0180356
UBXN4 UBX domain protein 4 -0.0180075
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0179831
DOCK11 dedicator of cytokinesis 11 -0.0174149
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0173157
FOSL1 FOS-like antigen 1 -0.0172521
RPL35A ribosomal protein L35a -0.0172357
IFITM1 interferon induced transmembrane protein 1 -0.0169995
RPS15 ribosomal protein S15 -0.016916
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0168849
MYADM myeloid-associated differentiation marker -0.016752
EIF5B eukaryotic translation initiation factor 5B -0.0165082
OSMR oncostatin M receptor -0.0162625
FERMT1 fermitin family member 1 -0.0161119
AREG amphiregulin -0.0159775
RPL32 ribosomal protein L32 -0.0158168
RPLP1 ribosomal protein, large, P1 -0.0155343
CFAP299 cilia and flagella associated protein 299 -0.0153864
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0152922
S100A10 S100 calcium binding protein A10 -0.0152617
RPLP0 ribosomal protein, large, P0 -0.0150972
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0150557
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0149278
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.014787
RPS29 ribosomal protein S29 -0.0146358
RPS5 ribosomal protein S5 -0.0142246
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0140183
FBXO17 F-box protein 17 -0.0139804
RPS25 ribosomal protein S25 -0.0139302
CALD1 caldesmon 1 -0.0138577
WARS1 tryptophanyl-tRNA synthetase 1 -0.0138287
PLIN3 perilipin 3 -0.0138123
NHSL1 NHS-like 1 -0.0137169
BMERB1 bMERB domain containing 1 -0.0137125
KRT19 keratin 19, type I -0.0136199
BABAM2 BRISC and BRCA1 A complex member 2 -0.0135621
ITGB4 integrin, beta 4 -0.0134173
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0133954
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0133327
COL5A2 collagen, type V, alpha 2 -0.0132575
ANTXR2 anthrax toxin receptor 2 -0.0131477