Baicalin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ELL2 elongation factor, RNA polymerase II, 2 0.115265
GRAMD1B GRAM domain containing 1B 0.107808
TOP1 topoisomerase (DNA) I 0.0934934
TXNRD1 thioredoxin reductase 1 0.0814291
TBC1D22A TBC1 domain family, member 22A 0.0807865
PM20D1 peptidase M20 domain containing 1 0.0712849
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0700719
SLTM SAFB-like, transcription modulator 0.0694612
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0662285
MCL1 myeloid cell leukemia 1 0.0661558
SPAG9 sperm associated antigen 9 0.0588005
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0567832
MYH9 myosin, heavy chain 9, non-muscle 0.0544003
RUNX1 runt-related transcription factor 1 0.0521813
MYOF myoferlin 0.0519113
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0504942
TSC22D2 TSC22 domain family, member 2 0.0498133
TES testin LIM domain protein 0.0461577
RTN4 reticulon 4 0.0447421
PDLIM5 PDZ and LIM domain 5 0.0436816
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0429683
GLS2 glutaminase 2 (liver, mitochondrial) 0.0413592
VMP1 vacuole membrane protein 1 0.0411409
CAMTA1 calmodulin binding transcription activator 1 0.0410725
VCL vinculin 0.0409778
GSK3B glycogen synthase kinase 3 beta 0.0400762
BCAR3 breast cancer anti-estrogen resistance 3 0.0395324
GCLC glutamate-cysteine ligase, catalytic subunit 0.0387196
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0384075
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0383409
NABP1 nucleic acid binding protein 1 0.0382903
ANKRD17 ankyrin repeat domain 17 0.0381057
DOCK5 dedicator of cytokinesis 5 0.036513
STRN3 striatin, calmodulin binding protein 3 0.0357911
LAMA4 laminin, alpha 4 0.0357843
ANKRD11 ankyrin repeat domain 11 0.0353207
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0331074
PDE4D phosphodiesterase 4D, cAMP-specific 0.0327914
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.032745
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0326009
PLEC plectin 0.0321385
SAMD4A sterile alpha motif domain containing 4A 0.031943
NPAS2 neuronal PAS domain protein 2 0.0318196
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0318153
UBA6 ubiquitin-like modifier activating enzyme 6 0.0317175
USP34 ubiquitin specific peptidase 34 0.0316845
RAB7A RAB7A, member RAS oncogene family 0.0312203
BMP6 bone morphogenetic protein 6 0.0310001
LRP12 low density lipoprotein receptor-related protein 12 0.0309781
EXT1 exostosin glycosyltransferase 1 0.0307468
AGO2 argonaute RISC catalytic component 2 0.0306433
SMYD3 SET and MYND domain containing 3 0.0306099
TRAPPC9 trafficking protein particle complex 9 0.0305042
SFPQ splicing factor proline/glutamine-rich 0.0303102
CCNL1 cyclin L1 0.030103
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0300116
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0297147
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0296545
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0293758
CSNK1A1 casein kinase 1, alpha 1 0.0292961
PUM2 pumilio RNA-binding family member 2 0.0291179
JMJD1C jumonji domain containing 1C 0.0290743
THSD4 thrombospondin, type I, domain containing 4 0.0284457
PSME4 proteasome (prosome, macropain) activator subunit 4 0.028332
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0280773
DTNA dystrobrevin, alpha 0.0279187
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0277453
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.027499
FAT1 FAT atypical cadherin 1 0.0273315
MACF1 microtubule-actin crosslinking factor 1 0.0265535
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0265263
DSCAM Down syndrome cell adhesion molecule 0.0265191
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0262454
ATP13A3 ATPase type 13A3 0.026074
OGA O-GlcNAcase 0.0260555
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0259961
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.025845
HYOU1 hypoxia up-regulated 1 0.0254831
CTNND1 catenin (cadherin-associated protein), delta 1 0.0252299
ZNF638 zinc finger protein 638 0.0251868
YTHDC1 YTH domain containing 1 0.0250262
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0250174
MSN moesin 0.0249723
RBM39 RNA binding motif protein 39 0.024748
NPTN neuroplastin 0.0246353
ACTN1 actinin, alpha 1 0.0243913
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0241956
KDM6A lysine (K)-specific demethylase 6A 0.0241465
SCEL sciellin 0.0238869
ZC3H11A zinc finger CCCH-type containing 11A 0.0238293
SETX senataxin 0.0237473
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0237419
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0236166
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0235657
SPRED2 sprouty-related, EVH1 domain containing 2 0.0234762
USP9X ubiquitin specific peptidase 9, X-linked 0.0233456
EPAS1 endothelial PAS domain protein 1 0.0232313
ATF6 activating transcription factor 6 0.0232082
SYAP1 synapse associated protein 1 0.0231442
ADAM9 ADAM metallopeptidase domain 9 0.0227517

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.29691
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.283452
TMSB10 thymosin beta 10 -0.136916
EGFR epidermal growth factor receptor -0.116365
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0943731
CAV1 caveolin 1, caveolae protein, 22kDa -0.0903752
NDRG1 N-myc downstream regulated 1 -0.0902495
S100A10 S100 calcium binding protein A10 -0.0813739
TPT1 tumor protein, translationally-controlled 1 -0.0774012
ZMYND8 zinc finger, MYND-type containing 8 -0.0740387
SOD2 superoxide dismutase 2, mitochondrial -0.0693784
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0691855
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0691508
PTMA prothymosin, alpha -0.0684743
LDHA lactate dehydrogenase A -0.0640214
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0601443
ACTG1 actin gamma 1 -0.0601399
IFI6 interferon, alpha-inducible protein 6 -0.0594751
B2M beta-2-microglobulin -0.0594121
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0588181
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0549156
EFNA5 ephrin-A5 -0.0542197
ENO1 enolase 1, (alpha) -0.053656
LAMC2 laminin, gamma 2 -0.0508981
STC1 stanniocalcin 1 -0.0503957
TRIM56 tripartite motif containing 56 -0.0492825
MT2A metallothionein 2A -0.0486578
SP100 SP100 nuclear antigen -0.0470886
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0468357
PKM pyruvate kinase, muscle -0.0465133
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0463126
AHNAK AHNAK nucleoprotein -0.0459601
LOC112694756 uncharaterized LOC112694756 -0.0440377
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0438873
HLA-B major histocompatibility complex, class I, B -0.0435263
LRP1B low density lipoprotein receptor-related protein 1B -0.0431819
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0429813
PTPRM protein tyrosine phosphatase, receptor type, M -0.0427451
CST3 cystatin C -0.0427384
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0426153
KRT18 keratin 18, type I -0.0420912
SEC61G Sec61 gamma subunit -0.0416998
ANKRD12 ankyrin repeat domain 12 -0.0407415
ANXA2 annexin A2 -0.039568
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0386182
RPL35A ribosomal protein L35a -0.0378196
BZW1 basic leucine zipper and W2 domains 1 -0.0370029
LAMB3 laminin, beta 3 -0.0364137
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0351945
RPS3 ribosomal protein S3 -0.035187
RNF213 ring finger protein 213 -0.0349858
EIF1 eukaryotic translation initiation factor 1 -0.0332176
BTG1 B-cell translocation gene 1, anti-proliferative -0.0324184
NCOA7 nuclear receptor coactivator 7 -0.0321148
GNAS GNAS complex locus -0.0318642
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0318486
DSG2 desmoglein 2 -0.031055
RPLP1 ribosomal protein, large, P1 -0.0310063
EGR1 early growth response 1 -0.0302113
MX1 MX dynamin-like GTPase 1 -0.0292767
S100A6 S100 calcium binding protein A6 -0.0291296
GM2A GM2 ganglioside activator -0.0291052
RPL30 ribosomal protein L30 -0.0289643
BIRC3 baculoviral IAP repeat containing 3 -0.0287882
RPL37A ribosomal protein L37a -0.0287387
RPS27A ribosomal protein S27a -0.0286318
FAM13A family with sequence similarity 13, member A -0.0281735
CCND1 cyclin D1 -0.0281419
RPS8 ribosomal protein S8 -0.0281195
CXCL8 chemokine (C-X-C motif) ligand 8 -0.027999
ASPH aspartate beta-hydroxylase -0.0277643
SLC38A1 solute carrier family 38, member 1 -0.0276857
RPL34 ribosomal protein L34 -0.0276138
CAV2 caveolin 2 -0.0273371
CSTB cystatin B (stefin B) -0.0271873
KRT19 keratin 19, type I -0.0269066
RPS24 ribosomal protein S24 -0.026882
ARRDC3 arrestin domain containing 3 -0.0261485
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.025755
PMP22 peripheral myelin protein 22 -0.0257445
KRT7 keratin 7, type II -0.0247299
AGR2 anterior gradient 2 -0.0245706
IER3 immediate early response 3 -0.0244635
FTH1 ferritin, heavy polypeptide 1 -0.024103
C15ORF48 chromosome 15 open reading frame 48 -0.0239188
BACE2 beta-site APP-cleaving enzyme 2 -0.0237322
AHNAK2 AHNAK nucleoprotein 2 -0.0233851
CP ceruloplasmin (ferroxidase) -0.0231458
RPS12 ribosomal protein S12 -0.0229975
IFI44L interferon-induced protein 44-like -0.0228686
CD99 CD99 molecule -0.0226797
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0226507
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0226433
RIGI RNA sensor RIG-I -0.0225929
PLSCR1 phospholipid scramblase 1 -0.0225806
RPL12 ribosomal protein L12 -0.0218357
H1-0 H1.0 linker histone -0.0218017
HLA-E major histocompatibility complex, class I, E -0.021691
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0216588
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0215506