Baicalin_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.0848056
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0761719
SMAD3 SMAD family member 3 0.0642635
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0628534
VEGFA vascular endothelial growth factor A 0.0547525
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0541192
GRB10 growth factor receptor-bound protein 10 0.0525535
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0521443
EFNA5 ephrin-A5 0.0510633
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0504647
NAV2 neuron navigator 2 0.045747
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0410864
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0368443
FNDC3B fibronectin type III domain containing 3B 0.0362783
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0338914
FAM20C family with sequence similarity 20, member C 0.0329456
LOXL2 lysyl oxidase-like 2 0.0306481
RUNX1 runt-related transcription factor 1 0.029264
EEF2 eukaryotic translation elongation factor 2 0.0291421
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0279238
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0276096
MYH9 myosin, heavy chain 9, non-muscle 0.026912
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0265612
TGM2 transglutaminase 2 0.0263727
RAD51B RAD51 paralog B 0.0260701
PRELID2 PRELI domain containing 2 0.0253908
SDK1 sidekick cell adhesion molecule 1 0.0253023
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0249583
MCL1 myeloid cell leukemia 1 0.0247603
EGFR epidermal growth factor receptor 0.0238949
SEPTIN9 septin 9 0.0237724
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0230708
SOD2 superoxide dismutase 2, mitochondrial 0.022892
INTS6 integrator complex subunit 6 0.0227824
STK38L serine/threonine kinase 38 like 0.0220028
DOCK5 dedicator of cytokinesis 5 0.0219062
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0209365
COL7A1 collagen, type VII, alpha 1 0.0206567
CEP250 centrosomal protein 250kDa 0.02063
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0202241
APLP2 amyloid beta (A4) precursor-like protein 2 0.0197808
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0196544
CCSER1 coiled-coil serine-rich protein 1 0.0195734
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0194588
SHB Src homology 2 domain containing adaptor protein B 0.0193648
TRIO trio Rho guanine nucleotide exchange factor 0.0193127
ATXN1 ataxin 1 0.0193107
WWTR1 WW domain containing transcription regulator 1 0.0189434
LRMDA leucine rich melanocyte differentiation associated 0.0187873
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0184845
SIK3 SIK family kinase 3 0.0184755
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0182597
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0180736
MYO10 myosin X 0.017979
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0178736
GLS2 glutaminase 2 (liver, mitochondrial) 0.0177663
ANGPTL4 angiopoietin-like 4 0.0174886
NFE2L1 nuclear factor, erythroid 2-like 1 0.0173213
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0170438
VMP1 vacuole membrane protein 1 0.0169718
ZNF638 zinc finger protein 638 0.0167736
ECE1 endothelin converting enzyme 1 0.0166124
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0160678
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0159189
WLS wntless Wnt ligand secretion mediator 0.0156788
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0154362
AUTS2 autism susceptibility candidate 2 0.0154221
SLIT2 slit homolog 2 (Drosophila) 0.015233
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0152303
LPP LIM domain containing preferred translocation partner in lipoma 0.0152
PDLIM5 PDZ and LIM domain 5 0.0149905
NOTCH2 notch 2 0.0146074
KSR1 kinase suppressor of ras 1 0.0145465
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0144731
EFCAB13 EF-hand calcium binding domain 13 0.0144449
NEBL nebulette 0.0141949
EXOC6B exocyst complex component 6B 0.0140931
NCOR2 nuclear receptor corepressor 2 0.0138414
HDAC9 histone deacetylase 9 0.0137439
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.013588
KCTD16 potassium channel tetramerization domain containing 16 0.0135086
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0134955
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0134158
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0132823
EHBP1L1 EH domain binding protein 1-like 1 0.0130534
PLEC plectin 0.0130298
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.012889
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0127101
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0127098
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.0126508
LGALS12 lectin, galactoside-binding, soluble, 12 0.0126483
RAB8B RAB8B, member RAS oncogene family 0.0126012
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0125129
LCOR ligand dependent nuclear receptor corepressor 0.0124681
FAM219A family with sequence similarity 219, member A 0.0124427
TPM3 tropomyosin 3 0.0123626
CPNE1 copine I 0.0123465
ZSWIM6 zinc finger, SWIM-type containing 6 0.0122157
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0122074
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.012111

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233465
VIM vimentin -0.219173
TMSB10 thymosin beta 10 -0.206814
TFPI2 tissue factor pathway inhibitor 2 -0.115392
NAMPT nicotinamide phosphoribosyltransferase -0.106289
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.104019
FN1 fibronectin 1 -0.0927746
FTL ferritin, light polypeptide -0.0913845
PTMA prothymosin, alpha -0.088836
STC1 stanniocalcin 1 -0.0822918
TPT1 tumor protein, translationally-controlled 1 -0.0822176
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.082143
S100A6 S100 calcium binding protein A6 -0.0813748
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0765099
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0700397
ZMYND8 zinc finger, MYND-type containing 8 -0.0698051
DPYD dihydropyrimidine dehydrogenase -0.0683919
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0670621
TM4SF1 transmembrane 4 L six family member 1 -0.0666648
EIF1 eukaryotic translation initiation factor 1 -0.0660607
LOX lysyl oxidase -0.0658062
WSB1 WD repeat and SOCS box containing 1 -0.0630945
RAB1A RAB1A, member RAS oncogene family -0.0596126
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0562757
OSMR oncostatin M receptor -0.055974
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0539251
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0526294
B2M beta-2-microglobulin -0.05038
ARHGAP5 Rho GTPase activating protein 5 -0.0501456
GLCCI1 glucocorticoid induced 1 -0.0501041
LMAN1 lectin, mannose-binding, 1 -0.0497515
ENO1 enolase 1, (alpha) -0.046405
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0462521
BTG1 B-cell translocation gene 1, anti-proliferative -0.0456803
RPLP1 ribosomal protein, large, P1 -0.0452423
IER3 immediate early response 3 -0.0431955
S100A10 S100 calcium binding protein A10 -0.0431749
NAP1L1 nucleosome assembly protein 1-like 1 -0.0428408
PDE4D phosphodiesterase 4D, cAMP-specific -0.0428241
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0427773
RPS21 ribosomal protein S21 -0.0427125
AKAP12 A kinase (PRKA) anchor protein 12 -0.041601
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0413086
RPS19 ribosomal protein S19 -0.0400069
RPL35A ribosomal protein L35a -0.0387603
TMSB4X thymosin beta 4, X-linked -0.0384447
IFI16 interferon, gamma-inducible protein 16 -0.0383673
VRK2 vaccinia related kinase 2 -0.0375075
KDM3A lysine (K)-specific demethylase 3A -0.0374609
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0371325
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0366261
RPL34 ribosomal protein L34 -0.0365383
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0362977
RPLP2 ribosomal protein, large, P2 -0.0362708
CD44 CD44 molecule (Indian blood group) -0.0361846
GCC2 GRIP and coiled-coil domain containing 2 -0.0361534
HLA-B major histocompatibility complex, class I, B -0.035547
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0354928
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0354699
PRSS23 protease, serine, 23 -0.0352686
RPS24 ribosomal protein S24 -0.03524
GOLGA4 golgin A4 -0.0346863
IL1B interleukin 1, beta -0.0341035
CLMP CXADR-like membrane protein -0.0340175
THBD thrombomodulin -0.0339537
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.033847
SNX9 sorting nexin 9 -0.0337977
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0336093
PRRC2C proline-rich coiled-coil 2C -0.0327891
H1-0 H1.0 linker histone -0.0327657
MEF2A myocyte enhancer factor 2A -0.032517
ARL4C ADP-ribosylation factor-like 4C -0.0320929
TMEM131 transmembrane protein 131 -0.0319893
AHNAK AHNAK nucleoprotein -0.0319869
RIOK3 RIO kinase 3 -0.031604
EGR1 early growth response 1 -0.0314087
BASP1 brain abundant, membrane attached signal protein 1 -0.0312704
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0309214
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0307373
RAB27B RAB27B, member RAS oncogene family -0.0306023
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0305933
MT2A metallothionein 2A -0.0305922
RPS6 ribosomal protein S6 -0.0302505
NUMB numb homolog (Drosophila) -0.029888
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0298405
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.029714
CP ceruloplasmin (ferroxidase) -0.0295816
ANKRD12 ankyrin repeat domain 12 -0.0291945
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0291691
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029098
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0290225
ESYT2 extended synaptotagmin-like protein 2 -0.0289854
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0288733
RPL31 ribosomal protein L31 -0.0285699
RPL32 ribosomal protein L32 -0.0283744
KTN1 kinectin 1 (kinesin receptor) -0.0281199
KPNB1 karyopherin (importin) beta 1 -0.0275641
SOX4 SRY (sex determining region Y)-box 4 -0.0275284
AKAP13 A kinase (PRKA) anchor protein 13 -0.0273993
TMEM263 transmembrane protein 263 -0.0273514