Baicalin_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.104932
FMNL2 formin-like 2 0.0850784
EEF2 eukaryotic translation elongation factor 2 0.078824
FTH1 ferritin, heavy polypeptide 1 0.0780313
MCL1 myeloid cell leukemia 1 0.0755262
UBASH3B ubiquitin associated and SH3 domain containing B 0.0744317
DOCK4 dedicator of cytokinesis 4 0.0735754
SMOC1 SPARC related modular calcium binding 1 0.0727235
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0715567
PCBP2 poly(rC) binding protein 2 0.0708771
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0690316
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0638589
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.061418
TMSB10 thymosin beta 10 0.0611257
FTL ferritin, light polypeptide 0.0605446
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0590725
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0589825
CMIP c-Maf inducing protein 0.0588215
ELL2 elongation factor, RNA polymerase II, 2 0.0570683
TRIO trio Rho guanine nucleotide exchange factor 0.0569299
ACTN1 actinin, alpha 1 0.0546603
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0542219
ANKRD11 ankyrin repeat domain 11 0.052551
FLNA filamin A, alpha 0.0518761
COPA coatomer protein complex, subunit alpha 0.0508347
WAC WW domain containing adaptor with coiled-coil 0.0485861
ZSWIM6 zinc finger, SWIM-type containing 6 0.0485532
FLNB filamin B, beta 0.0483088
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0474913
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0458503
APP amyloid beta (A4) precursor protein 0.0450658
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0441039
ZFAND3 zinc finger, AN1-type domain 3 0.0439309
SAMD4A sterile alpha motif domain containing 4A 0.0437609
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0430459
RAB7A RAB7A, member RAS oncogene family 0.0414875
PTPRJ protein tyrosine phosphatase, receptor type, J 0.041351
IGFBP3 insulin-like growth factor binding protein 3 0.0411946
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0401996
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0392238
CYTH1 cytohesin 1 0.0390999
NDRG1 N-myc downstream regulated 1 0.0390855
FNDC3B fibronectin type III domain containing 3B 0.0369658
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0362886
EXT1 exostosin glycosyltransferase 1 0.0348999
FOXO3 forkhead box O3 0.0346076
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0345781
HLA-A major histocompatibility complex, class I, A 0.0345545
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.034334
CTBP2 C-terminal binding protein 2 0.0338931
RERE arginine-glutamic acid dipeptide (RE) repeats 0.033833
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0326823
CALR calreticulin 0.0322592
APLP2 amyloid beta (A4) precursor-like protein 2 0.0318784
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0311945
UGCG UDP-glucose ceramide glucosyltransferase 0.0311306
MYO1E myosin IE 0.0309852
LPP LIM domain containing preferred translocation partner in lipoma 0.0307597
AKAP13 A kinase (PRKA) anchor protein 13 0.0307098
KYNU kynureninase 0.0304595
FNBP1L formin binding protein 1-like 0.0302831
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0300272
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0297966
PUM1 pumilio RNA-binding family member 1 0.029507
SPRED2 sprouty-related, EVH1 domain containing 2 0.0291915
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0290217
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0275211
SIK3 SIK family kinase 3 0.027266
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0272131
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0271271
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0270577
LDHA lactate dehydrogenase A 0.0270053
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0269989
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0264872
USP36 ubiquitin specific peptidase 36 0.0263749
KDM5B lysine (K)-specific demethylase 5B 0.0260206
YTHDC1 YTH domain containing 1 0.0258724
RICTOR RPTOR independent companion of MTOR, complex 2 0.0256283
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0245617
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0244435
DSCAM Down syndrome cell adhesion molecule 0.0244426
MACF1 microtubule-actin crosslinking factor 1 0.0240976
PTK2 protein tyrosine kinase 2 0.0240219
TOP1 topoisomerase (DNA) I 0.0237516
MED13 mediator complex subunit 13 0.0236859
ASXL1 additional sex combs like transcriptional regulator 1 0.0236847
BIRC6 baculoviral IAP repeat containing 6 0.0235264
BCAR3 breast cancer anti-estrogen resistance 3 0.0233303
INTS6 integrator complex subunit 6 0.0233082
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0229434
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0228757
CUL3 cullin 3 0.0228625
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.022857
CABIN1 calcineurin binding protein 1 0.022797
BRD2 bromodomain containing 2 0.0227752
AHNAK AHNAK nucleoprotein 0.0227635
IFRD1 interferon-related developmental regulator 1 0.022451
PARD3 par-3 family cell polarity regulator 0.0221397
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0221109
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0221087

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.198182
GRAMD1B GRAM domain containing 1B -0.172954
TXNRD1 thioredoxin reductase 1 -0.156835
TM4SF1 transmembrane 4 L six family member 1 -0.132664
PDE4D phosphodiesterase 4D, cAMP-specific -0.104241
TFPI2 tissue factor pathway inhibitor 2 -0.101169
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0768917
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0722502
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0702804
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0600577
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0592496
PM20D1 peptidase M20 domain containing 1 -0.0590217
PTMA prothymosin, alpha -0.0548298
AKAP12 A kinase (PRKA) anchor protein 12 -0.0510118
RPS2 ribosomal protein S2 -0.0505577
MKI67 marker of proliferation Ki-67 -0.0466778
RTN4 reticulon 4 -0.0436657
EIF1 eukaryotic translation initiation factor 1 -0.0424853
BIRC3 baculoviral IAP repeat containing 3 -0.0419564
POTEF POTE ankyrin domain family, member F -0.0413999
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0413788
RPL19 ribosomal protein L19 -0.0407713
RPL7 ribosomal protein L7 -0.0389246
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0384531
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0380217
NAMPT nicotinamide phosphoribosyltransferase -0.0379611
CENPF centromere protein F, 350/400kDa -0.0379179
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0374075
MIS18BP1 MIS18 binding protein 1 -0.0357525
WWOX WW domain containing oxidoreductase -0.0349392
PFDN2 prefoldin subunit 2 -0.0339454
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0338226
KIF5B kinesin family member 5B -0.0325472
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0325457
TPT1 tumor protein, translationally-controlled 1 -0.0315445
C15ORF48 chromosome 15 open reading frame 48 -0.0309547
LAMB1 laminin, beta 1 -0.0298981
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298376
DGKD diacylglycerol kinase, delta 130kDa -0.0295464
VIM vimentin -0.0294424
SRGN serglycin -0.0294296
BIRC2 baculoviral IAP repeat containing 2 -0.0290943
RPS25 ribosomal protein S25 -0.028307
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.028224
FGB fibrinogen beta chain -0.0276839
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0275328
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0269651
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0267537
RPS21 ribosomal protein S21 -0.0264762
RPS12 ribosomal protein S12 -0.0260741
GOLT1B golgi transport 1B -0.0258082
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0256253
RPS27A ribosomal protein S27a -0.0255902
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0252828
MAP1B microtubule-associated protein 1B -0.0251633
NCEH1 neutral cholesterol ester hydrolase 1 -0.0249997
RFWD3 ring finger and WD repeat domain 3 -0.0249138
BABAM2 BRISC and BRCA1 A complex member 2 -0.0248266
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0241157
KTN1 kinectin 1 (kinesin receptor) -0.0239891
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0239389
CBX5 chromobox homolog 5 -0.0238293
BCLAF1 BCL2-associated transcription factor 1 -0.0237316
RPS23 ribosomal protein S23 -0.0236335
OSMR oncostatin M receptor -0.0234707
NNMT nicotinamide N-methyltransferase -0.0234673
DARS1 aspartyl-tRNA synthetase 1 -0.0233302
YBX3 Y box binding protein 3 -0.0232338
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0229736
TBC1D5 TBC1 domain family, member 5 -0.0227516
RPL4 ribosomal protein L4 -0.0226886
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0224779
CDCP1 CUB domain containing protein 1 -0.0223795
SRPK1 SRSF protein kinase 1 -0.0223435
TPX2 TPX2, microtubule-associated -0.022039
S100A6 S100 calcium binding protein A6 -0.0218847
LYPLA1 lysophospholipase I -0.0217159
CLTC clathrin, heavy chain (Hc) -0.0215339
HSPA8 heat shock 70kDa protein 8 -0.0214715
CFLAR CASP8 and FADD-like apoptosis regulator -0.0214621
TPM4 tropomyosin 4 -0.0214111
AREG amphiregulin -0.0213883
ARL5B ADP-ribosylation factor-like 5B -0.0212283
UPP1 uridine phosphorylase 1 -0.0207644
NUSAP1 nucleolar and spindle associated protein 1 -0.0207006
AURKA aurora kinase A -0.0205331
RRM2 ribonucleotide reductase M2 -0.0204174
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.020407
NFE2L2 nuclear factor, erythroid 2-like 2 -0.020311
SP3 Sp3 transcription factor -0.0202398
TNPO1 transportin 1 -0.019762
LDHB lactate dehydrogenase B -0.0196689
ANLN anillin, actin binding protein -0.0196412
RPS6 ribosomal protein S6 -0.0196106
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0192323
SEPTIN10 septin 10 -0.0191091
IMMT inner membrane protein, mitochondrial -0.0190625
STC1 stanniocalcin 1 -0.0189419
TUBA1B tubulin, alpha 1b -0.0188096
UBXN4 UBX domain protein 4 -0.0187792