Baicalin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SAMD4A sterile alpha motif domain containing 4A 0.164647
IGFBP3 insulin-like growth factor binding protein 3 0.145895
GRB10 growth factor receptor-bound protein 10 0.127749
LIMCH1 LIM and calponin homology domains 1 0.113725
VEGFA vascular endothelial growth factor A 0.0856288
CANX calnexin 0.0823967
EEF2 eukaryotic translation elongation factor 2 0.0810328
LPP LIM domain containing preferred translocation partner in lipoma 0.0804242
LAMB3 laminin, beta 3 0.0738271
EFNA5 ephrin-A5 0.0704035
PLEC plectin 0.0609708
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0592445
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0551049
MYH9 myosin, heavy chain 9, non-muscle 0.0516054
PCBP2 poly(rC) binding protein 2 0.051263
FNDC3B fibronectin type III domain containing 3B 0.0508339
APLP2 amyloid beta (A4) precursor-like protein 2 0.0495498
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0495463
ARRDC3 arrestin domain containing 3 0.0465099
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0463455
ZSWIM6 zinc finger, SWIM-type containing 6 0.04524
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.044979
EXT1 exostosin glycosyltransferase 1 0.043253
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0423329
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0422695
CD109 CD109 molecule 0.0416707
CALR calreticulin 0.0410404
FNIP1 folliculin interacting protein 1 0.0400627
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0400551
GOLGB1 golgin B1 0.0397025
AHNAK2 AHNAK nucleoprotein 2 0.0390585
BZW1 basic leucine zipper and W2 domains 1 0.0386505
FLNB filamin B, beta 0.0385636
MCL1 myeloid cell leukemia 1 0.0381457
FTH1 ferritin, heavy polypeptide 1 0.0377848
RAI14 retinoic acid induced 14 0.0377803
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0355208
RCOR1 REST corepressor 1 0.0352892
KMT2C lysine (K)-specific methyltransferase 2C 0.0349254
TSC22D2 TSC22 domain family, member 2 0.0348253
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0344732
FAM13A family with sequence similarity 13, member A 0.0341909
CTSB cathepsin B 0.0341852
SEC31A SEC31 homolog A (S. cerevisiae) 0.0341709
MYO1E myosin IE 0.0340671
TMSB4X thymosin beta 4, X-linked 0.0338143
ANXA2 annexin A2 0.0337329
TTC3 tetratricopeptide repeat domain 3 0.0336736
RNF213 ring finger protein 213 0.0335867
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0325817
BLZF1 basic leucine zipper nuclear factor 1 0.0325386
MSI2 musashi RNA-binding protein 2 0.0314406
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311049
NAV2 neuron navigator 2 0.0310351
HLA-A major histocompatibility complex, class I, A 0.0309663
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0306053
RPSA ribosomal protein SA 0.0304459
TIMP2 TIMP metallopeptidase inhibitor 2 0.0303961
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0301141
ERBIN erbb2 interacting protein 0.0296409
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0293123
VCL vinculin 0.0292737
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0292637
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0292345
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0291797
UBE2H ubiquitin-conjugating enzyme E2H 0.0289087
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0286406
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0285616
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0284868
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0283573
AHNAK AHNAK nucleoprotein 0.0282791
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.02814
TMEM165 transmembrane protein 165 0.0281042
FLNA filamin A, alpha 0.0278057
KDM2A lysine (K)-specific demethylase 2A 0.0276717
ATP11A ATPase, class VI, type 11A 0.0275129
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0274329
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0273078
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0272423
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0271398
DTNA dystrobrevin, alpha 0.026977
CTBP2 C-terminal binding protein 2 0.0268893
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.026659
KDM5B lysine (K)-specific demethylase 5B 0.0266588
FBXO32 F-box protein 32 0.0264972
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0263965
SH3KBP1 SH3-domain kinase binding protein 1 0.025504
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.025487
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0253833
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0253215
TUFT1 tuftelin 1 0.0251497
MYOF myoferlin 0.0250084
PKM pyruvate kinase, muscle 0.0249403
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0248872
RBM47 RNA binding motif protein 47 0.0246982
TRIO trio Rho guanine nucleotide exchange factor 0.0246805
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246713
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0245719
PDLIM5 PDZ and LIM domain 5 0.0244091
TBC1D22A TBC1 domain family, member 22A 0.024207

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.250499
NAMPT nicotinamide phosphoribosyltransferase -0.108897
FTL ferritin, light polypeptide -0.104625
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0892341
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0813624
S100A6 S100 calcium binding protein A6 -0.0807172
ASPH aspartate beta-hydroxylase -0.077715
TPT1 tumor protein, translationally-controlled 1 -0.0763899
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0748114
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0708811
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0677645
RPS23 ribosomal protein S23 -0.06567
TMSB10 thymosin beta 10 -0.0643702
RPL32 ribosomal protein L32 -0.0632129
PTMA prothymosin, alpha -0.0627923
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0615047
MT2A metallothionein 2A -0.0583674
ALCAM activated leukocyte cell adhesion molecule -0.0583419
RPLP2 ribosomal protein, large, P2 -0.0563584
POTEF POTE ankyrin domain family, member F -0.0561334
HMGA1 high mobility group AT-hook 1 -0.0547865
RPS6 ribosomal protein S6 -0.051963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0498357
AREG amphiregulin -0.0488742
TFG TRK-fused gene -0.0480476
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.047615
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0457022
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0456606
RPS19 ribosomal protein S19 -0.0447805
S100A10 S100 calcium binding protein A10 -0.0439556
RPL12 ribosomal protein L12 -0.0422587
RPL34 ribosomal protein L34 -0.0415025
RACK1 receptor for activated C kinase 1 -0.0413737
IFI27 interferon, alpha-inducible protein 27 -0.0412586
RPL19 ribosomal protein L19 -0.0412175
RPL7 ribosomal protein L7 -0.0409792
PAPOLA poly(A) polymerase alpha -0.0407599
MSMO1 methylsterol monooxygenase 1 -0.0402901
RPL11 ribosomal protein L11 -0.0398439
ACTG1 actin gamma 1 -0.0395947
RPS13 ribosomal protein S13 -0.0386567
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.037782
EIF1 eukaryotic translation initiation factor 1 -0.0376986
RPS8 ribosomal protein S8 -0.037635
RPL23 ribosomal protein L23 -0.0368384
RPS29 ribosomal protein S29 -0.0357931
LY6E lymphocyte antigen 6 complex, locus E -0.0355641
DSTN destrin (actin depolymerizing factor) -0.0354496
RPLP0 ribosomal protein, large, P0 -0.035268
GOLGA4 golgin A4 -0.0351988
NAP1L1 nucleosome assembly protein 1-like 1 -0.0349606
GPX4 glutathione peroxidase 4 -0.0346616
CCNI cyclin I -0.0342688
RPS2 ribosomal protein S2 -0.0337043
CLINT1 clathrin interactor 1 -0.0333675
RPL28 ribosomal protein L28 -0.033206
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0322406
RPL15 ribosomal protein L15 -0.032191
UBC ubiquitin C -0.0321835
RPS24 ribosomal protein S24 -0.0319641
RPL9 ribosomal protein L9 -0.0319519
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0319051
RPS5 ribosomal protein S5 -0.0317652
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0315526
RNF145 ring finger protein 145 -0.0314115
MKI67 marker of proliferation Ki-67 -0.0313103
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0308839
RPS25 ribosomal protein S25 -0.030581
CCNL1 cyclin L1 -0.0303217
ERRFI1 ERBB receptor feedback inhibitor 1 -0.03006
TXNRD1 thioredoxin reductase 1 -0.0298582
EPCAM epithelial cell adhesion molecule -0.0297703
RPLP1 ribosomal protein, large, P1 -0.0296298
TUBA1B tubulin, alpha 1b -0.0296077
UPP1 uridine phosphorylase 1 -0.0294348
ANLN anillin, actin binding protein -0.0293018
TRA2B transformer 2 beta homolog (Drosophila) -0.0292185
RPL5 ribosomal protein L5 -0.0291929
RPS3 ribosomal protein S3 -0.0291697
RPL27A ribosomal protein L27a -0.029158
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.029134
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0290944
RPS15 ribosomal protein S15 -0.0288255
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0281156
RPS14 ribosomal protein S14 -0.0278056
RPS21 ribosomal protein S21 -0.0277881
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0277355
RYBP RING1 and YY1 binding protein -0.027478
RPL38 ribosomal protein L38 -0.0273999
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0273545
RPS27A ribosomal protein S27a -0.0271924
TM4SF1 transmembrane 4 L six family member 1 -0.0271832
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0271074
CDK17 cyclin-dependent kinase 17 -0.0269074
H3-3B H3.3 histone B -0.0263758
RPL37A ribosomal protein L37a -0.0261593
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0258521
SEPTIN7 septin 7 -0.0255872
RPL36A ribosomal protein L36a -0.0255212
MDK midkine (neurite growth-promoting factor 2) -0.025403