Baicalin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Baicalin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 0.0753059
NTM neurotrimin 0.0690633
FNDC3B fibronectin type III domain containing 3B 0.0662331
DST dystonin 0.0497227
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0484745
HDAC9 histone deacetylase 9 0.0409794
ANKRD33B ankyrin repeat domain 33B 0.0373992
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0351285
ZNF292 zinc finger protein 292 0.0345736
COL5A2 collagen, type V, alpha 2 0.034251
TRIO trio Rho guanine nucleotide exchange factor 0.0322968
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0321484
ZEB2 zinc finger E-box binding homeobox 2 0.0299219
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0294469
ADAM9 ADAM metallopeptidase domain 9 0.0287647
ZNF608 zinc finger protein 608 0.0286807
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0268729
KDM3A lysine (K)-specific demethylase 3A 0.0262775
CDC73 cell division cycle 73 0.0261239
UTRN utrophin 0.0260325
SAMD4A sterile alpha motif domain containing 4A 0.0252328
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0248364
NCKAP1 NCK-associated protein 1 0.0239812
MEMO1 mediator of cell motility 1 0.0239722
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.023726
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0236044
WDR43 WD repeat domain 43 0.0235754
APP amyloid beta (A4) precursor protein 0.0231353
KIF1B kinesin family member 1B 0.0223254
PICALM phosphatidylinositol binding clathrin assembly protein 0.0221953
KMT2C lysine (K)-specific methyltransferase 2C 0.0218013
KDM6A lysine (K)-specific demethylase 6A 0.0215774
DPYD dihydropyrimidine dehydrogenase 0.0204213
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0202983
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.02014
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0201009
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0198181
RLF rearranged L-myc fusion 0.0197036
CAMKMT calmodulin-lysine N-methyltransferase 0.0196838
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0196581
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0195972
THBS1 thrombospondin 1 0.0194476
MARCHF6 membrane associated ring-CH-type finger 6 0.0192978
SPAG9 sperm associated antigen 9 0.0192672
CTPS1 CTP synthase 1 0.0190669
USP9X ubiquitin specific peptidase 9, X-linked 0.0190373
CORO1C coronin, actin binding protein, 1C 0.0189844
GLS2 glutaminase 2 (liver, mitochondrial) 0.0189184
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0188801
ELF2 E74-like factor 2 (ets domain transcription factor) 0.018835
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0187662
IGF1R insulin-like growth factor 1 receptor 0.0186504
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0185258
STAG2 stromal antigen 2 0.0185174
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0183339
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0182747
SRP54 signal recognition particle 54kDa 0.0181742
DIDO1 death inducer-obliterator 1 0.0180286
USP3 ubiquitin specific peptidase 3 0.0179807
MED13L mediator complex subunit 13-like 0.0177474
NHSL1 NHS-like 1 0.0177415
ORC4 origin recognition complex, subunit 4 0.0176791
ZNF385D zinc finger protein 385D 0.0176117
PDS5B PDS5 cohesin associated factor B 0.0174964
ECT2 epithelial cell transforming 2 0.0172848
USP25 ubiquitin specific peptidase 25 0.0172809
ADGRG6 adhesion G protein-coupled receptor G6 0.0172394
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0169715
PUM2 pumilio RNA-binding family member 2 0.0168571
RABGAP1L RAB GTPase activating protein 1-like 0.0167088
FGFR1OP2 FGFR1 oncogene partner 2 0.016509
MATR3 matrin 3 0.0165034
BLTP1 bridge-like lipid transfer protein family member 1 0.0164998
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0164243
USP53 ubiquitin specific peptidase 53 0.0163404
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0163146
FLNA filamin A, alpha 0.0161922
NAMPT nicotinamide phosphoribosyltransferase 0.0160899
FAM171B family with sequence similarity 171, member B 0.0160511
TMEM64 transmembrane protein 64 0.0160446
NFIB nuclear factor I/B 0.0160296
KMT2E lysine (K)-specific methyltransferase 2E 0.0159412
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.01588
ARB2A ARB2 cotranscriptional regulator A 0.0158579
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0158226
STRN3 striatin, calmodulin binding protein 3 0.0155839
AFF4 AF4/FMR2 family, member 4 0.0155002
TSEN15 TSEN15 tRNA splicing endonuclease subunit 0.0153985
RBM33 RNA binding motif protein 33 0.0150376
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0150233
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0150194
MARCHF7 membrane associated ring-CH-type finger 7 0.0149447
ZNF217 zinc finger protein 217 0.0145232
SMYD3 SET and MYND domain containing 3 0.0145113
LRP12 low density lipoprotein receptor-related protein 12 0.0144355
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0144007
RICTOR RPTOR independent companion of MTOR, complex 2 0.0143654
AHNAK AHNAK nucleoprotein 0.0143482
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0143028
CELF2 CUGBP, Elav-like family member 2 0.0142381

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.269119
TMSB10 thymosin beta 10 -0.193878
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.142227
PTMA prothymosin, alpha -0.12818
RPS16 ribosomal protein S16 -0.108526
RPS6 ribosomal protein S6 -0.102542
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.101889
RPL35A ribosomal protein L35a -0.0890456
RPS8 ribosomal protein S8 -0.087924
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0794105
TPT1 tumor protein, translationally-controlled 1 -0.0787544
MDK midkine (neurite growth-promoting factor 2) -0.0781539
COL11A1 collagen, type XI, alpha 1 -0.0767288
ACTG1 actin gamma 1 -0.0757938
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0690688
WSB1 WD repeat and SOCS box containing 1 -0.06865
GPC3 glypican 3 -0.0685753
PCLO piccolo presynaptic cytomatrix protein -0.0658614
PCDH9 protocadherin 9 -0.0658177
RPL11 ribosomal protein L11 -0.0654082
PHIP pleckstrin homology domain interacting protein -0.0600658
GNAS GNAS complex locus -0.0580808
EIF1 eukaryotic translation initiation factor 1 -0.0580651
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0564376
RPS19 ribosomal protein S19 -0.056408
RPL23 ribosomal protein L23 -0.0556442
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0552393
ENO1 enolase 1, (alpha) -0.054205
RPS12 ribosomal protein S12 -0.0538677
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0536875
NACA nascent polypeptide-associated complex alpha subunit -0.0527655
RPL31 ribosomal protein L31 -0.0523504
PGK1 phosphoglycerate kinase 1 -0.0501929
B2M beta-2-microglobulin -0.0492826
ISG15 ISG15 ubiquitin-like modifier -0.0480715
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0477621
RPLP1 ribosomal protein, large, P1 -0.0475928
COL1A2 collagen, type I, alpha 2 -0.0475889
RPL37 ribosomal protein L37 -0.0471624
RPL9 ribosomal protein L9 -0.0469995
RPS3 ribosomal protein S3 -0.04624
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0459646
RPL12 ribosomal protein L12 -0.0455977
RPL19 ribosomal protein L19 -0.0436048
RPS27A ribosomal protein S27a -0.0434055
RPLP0 ribosomal protein, large, P0 -0.0431111
FTL ferritin, light polypeptide -0.0430186
RPLP2 ribosomal protein, large, P2 -0.0418376
RPS13 ribosomal protein S13 -0.0417557
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.041675
MARCKS myristoylated alanine-rich protein kinase C substrate -0.041622
HSPB1 heat shock 27kDa protein 1 -0.0415089
RPS25 ribosomal protein S25 -0.0411828
APOE apolipoprotein E -0.040962
RPL5 ribosomal protein L5 -0.0408083
CADM2 cell adhesion molecule 2 -0.0406346
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0400151
RPL34 ribosomal protein L34 -0.0395829
NRG1 neuregulin 1 -0.0391769
RPS21 ribosomal protein S21 -0.0390167
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0389686
RPL37A ribosomal protein L37a -0.0389424
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0388314
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0386528
SNX6 sorting nexin 6 -0.0385928
FST follistatin -0.0385868
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0383981
RPL26 ribosomal protein L26 -0.0379299
S100A9 S100 calcium binding protein A9 -0.0376005
RPS24 ribosomal protein S24 -0.0372384
MYL12B myosin, light chain 12B, regulatory -0.0366236
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0365157
RPL36A ribosomal protein L36a -0.0363663
SERF2 small EDRK-rich factor 2 -0.0361233
RPL30 ribosomal protein L30 -0.0338868
LRRC4C leucine rich repeat containing 4C -0.0331773
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0320247
S100A10 S100 calcium binding protein A10 -0.031934
ADGRV1 adhesion G protein-coupled receptor V1 -0.031822
SRRM2 serine/arginine repetitive matrix 2 -0.031795
CNRIP1 cannabinoid receptor interacting protein 1 -0.0317432
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0315328
MT2A metallothionein 2A -0.031353
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0307306
WASF2 WAS protein family, member 2 -0.0291883
NAP1L1 nucleosome assembly protein 1-like 1 -0.0291068
RPS14 ribosomal protein S14 -0.0290808
RPS5 ribosomal protein S5 -0.0288643
RPL7 ribosomal protein L7 -0.0286909
RPS27 ribosomal protein S27 -0.0285274
RPL36 ribosomal protein L36 -0.0285157
FBXO17 F-box protein 17 -0.0283348
RPL7A ribosomal protein L7a -0.028035
RPS28 ribosomal protein S28 -0.0276435
RPL8 ribosomal protein L8 -0.0270735
RPS17 ribosomal protein S17 -0.0269865
BEX3 brain expressed X-linked 3 -0.0268332
ANKRD12 ankyrin repeat domain 12 -0.026553
RPS10 ribosomal protein S10 -0.0264303
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0263407