Baicalin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0901573
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0842297
COL6A3 collagen, type VI, alpha 3 0.0733315
FN1 fibronectin 1 0.0705538
FNDC3B fibronectin type III domain containing 3B 0.0681849
SOD2 superoxide dismutase 2, mitochondrial 0.0658878
SMAD3 SMAD family member 3 0.0563718
NAMPT nicotinamide phosphoribosyltransferase 0.0559225
TRIO trio Rho guanine nucleotide exchange factor 0.0545693
PDE10A phosphodiesterase 10A 0.0467344
ELL2 elongation factor, RNA polymerase II, 2 0.0455154
NAV2 neuron navigator 2 0.0433411
VCL vinculin 0.0406441
DST dystonin 0.040057
FRMD4A FERM domain containing 4A 0.0394032
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0392057
BICC1 BicC family RNA binding protein 1 0.0380947
USP9X ubiquitin specific peptidase 9, X-linked 0.0379111
MSN moesin 0.0354967
EXT1 exostosin glycosyltransferase 1 0.034159
TNS3 tensin 3 0.0328679
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.031263
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0312527
MYOF myoferlin 0.0305191
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0303837
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0266391
SMYD3 SET and MYND domain containing 3 0.0263707
NAV1 neuron navigator 1 0.0259405
AFDN afadin, adherens junction formation factor 0.0254108
VCAN versican 0.0253255
PPARD peroxisome proliferator-activated receptor delta 0.0252598
MACF1 microtubule-actin crosslinking factor 1 0.0252304
FAM20C family with sequence similarity 20, member C 0.0251173
ATXN1 ataxin 1 0.0249467
HELZ helicase with zinc finger 0.0245612
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0245443
TENT5A terminal nucleotidyltransferase 5A 0.0242139
GLIS3 GLIS family zinc finger 3 0.0241496
EPAS1 endothelial PAS domain protein 1 0.0231784
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0228317
ZFAND3 zinc finger, AN1-type domain 3 0.0222956
SPAG9 sperm associated antigen 9 0.0222044
PRELID2 PRELI domain containing 2 0.0220012
ZBTB38 zinc finger and BTB domain containing 38 0.0218796
COL5A1 collagen, type V, alpha 1 0.0211563
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0210085
AHNAK AHNAK nucleoprotein 0.0209062
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0202069
BCAR3 breast cancer anti-estrogen resistance 3 0.0200089
ATP13A3 ATPase type 13A3 0.0199497
QKI QKI, KH domain containing, RNA binding 0.0199198
SDK1 sidekick cell adhesion molecule 1 0.0198371
FLNA filamin A, alpha 0.0196701
VMP1 vacuole membrane protein 1 0.0196128
ZNF292 zinc finger protein 292 0.0193292
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0192609
LPP LIM domain containing preferred translocation partner in lipoma 0.0191662
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0188924
UBA6 ubiquitin-like modifier activating enzyme 6 0.018292
RUNX1 runt-related transcription factor 1 0.0181016
PFKP phosphofructokinase, platelet 0.0180411
FNIP1 folliculin interacting protein 1 0.0180123
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0179641
VEGFA vascular endothelial growth factor A 0.0179561
DENND5A DENN/MADD domain containing 5A 0.0177175
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0175993
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0172141
SVIL supervillin 0.0171499
ANO6 anoctamin 6 0.0171114
RTN4 reticulon 4 0.0171104
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.017039
KDM6A lysine (K)-specific demethylase 6A 0.0167874
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0167168
IGF2R insulin-like growth factor 2 receptor 0.0164184
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0163934
NIBAN2 niban apoptosis regulator 2 0.0163781
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0163627
STAG2 stromal antigen 2 0.0158732
MKI67 marker of proliferation Ki-67 0.0157952
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.015728
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0157137
CLIC4 chloride intracellular channel 4 0.0152258
TRIP12 thyroid hormone receptor interactor 12 0.0152062
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0151739
KIF13A kinesin family member 13A 0.0150573
SHB Src homology 2 domain containing adaptor protein B 0.0149931
ACTN1 actinin, alpha 1 0.014871
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0147809
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0146179
ERBIN erbb2 interacting protein 0.0143811
TGM2 transglutaminase 2 0.0143343
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0142323
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0142298
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0141906
TBC1D5 TBC1 domain family, member 5 0.0141378
CCNL1 cyclin L1 0.0141132
IL6ST interleukin 6 signal transducer 0.0140079
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0140076
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.013985
COL7A1 collagen, type VII, alpha 1 0.0138225

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.270488
HLA-B major histocompatibility complex, class I, B -0.123732
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115206
FTL ferritin, light polypeptide -0.108967
MT2A metallothionein 2A -0.10098
TMSB10 thymosin beta 10 -0.098799
RPS12 ribosomal protein S12 -0.0816378
TPT1 tumor protein, translationally-controlled 1 -0.0757669
B2M beta-2-microglobulin -0.0717291
HLA-A major histocompatibility complex, class I, A -0.0669845
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0657651
RPS8 ribosomal protein S8 -0.0645989
RPS3 ribosomal protein S3 -0.0625798
RPS6 ribosomal protein S6 -0.0625219
RPL37A ribosomal protein L37a -0.0617469
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0617286
LDHA lactate dehydrogenase A -0.0615629
EIF1 eukaryotic translation initiation factor 1 -0.0608212
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0602127
RPL35A ribosomal protein L35a -0.0565925
ADM adrenomedullin -0.0557089
NDRG1 N-myc downstream regulated 1 -0.0550565
RPL23 ribosomal protein L23 -0.0516906
IER3 immediate early response 3 -0.0452138
PTMA prothymosin, alpha -0.0450355
RPLP1 ribosomal protein, large, P1 -0.043556
RPS13 ribosomal protein S13 -0.0417234
RPL11 ribosomal protein L11 -0.0409894
IFITM3 interferon induced transmembrane protein 3 -0.0409335
FTH1 ferritin, heavy polypeptide 1 -0.0403403
NAP1L1 nucleosome assembly protein 1-like 1 -0.039732
RPL9 ribosomal protein L9 -0.0397262
RPL26 ribosomal protein L26 -0.0396597
BTG1 B-cell translocation gene 1, anti-proliferative -0.0394536
ENO1 enolase 1, (alpha) -0.0372392
RACK1 receptor for activated C kinase 1 -0.0368854
PGK1 phosphoglycerate kinase 1 -0.0368655
BASP1 brain abundant, membrane attached signal protein 1 -0.0359346
RPL12 ribosomal protein L12 -0.0345705
RPLP2 ribosomal protein, large, P2 -0.0344797
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0328608
RPS19 ribosomal protein S19 -0.0327394
ACTG1 actin gamma 1 -0.0322689
RPS27A ribosomal protein S27a -0.0322024
RPL5 ribosomal protein L5 -0.0318026
RPL36 ribosomal protein L36 -0.031703
RPL31 ribosomal protein L31 -0.03075
RPL37 ribosomal protein L37 -0.0304357
RPS4X ribosomal protein S4, X-linked -0.0303222
RPS17 ribosomal protein S17 -0.0296898
RPL19 ribosomal protein L19 -0.0295861
S100A9 S100 calcium binding protein A9 -0.0285932
IFI6 interferon, alpha-inducible protein 6 -0.028527
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0284849
RPS24 ribosomal protein S24 -0.0278986
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.027198
PLIN2 perilipin 2 -0.0269991
RPL13A ribosomal protein L13a -0.0263864
RPS10 ribosomal protein S10 -0.0263277
RPS14 ribosomal protein S14 -0.0262128
SQSTM1 sequestosome 1 -0.0260708
RPS23 ribosomal protein S23 -0.0258485
CALR calreticulin -0.0258398
ENO2 enolase 2 (gamma, neuronal) -0.0257388
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0256163
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0255513
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0248962
RPLP0 ribosomal protein, large, P0 -0.0247221
HLA-E major histocompatibility complex, class I, E -0.0245942
LOC112694756 uncharaterized LOC112694756 -0.0245294
EGR1 early growth response 1 -0.0244003
RPL34 ribosomal protein L34 -0.0243615
RPS21 ribosomal protein S21 -0.024145
MT1X metallothionein 1X -0.0233931
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0233786
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0228196
ATF4 activating transcription factor 4 -0.0227523
RPL36A ribosomal protein L36a -0.0227488
IFITM1 interferon induced transmembrane protein 1 -0.0221098
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0210116
LOC102724023 ES1 protein homolog, mitochondrial -0.020993
SFTPA2 surfactant protein A2 -0.0208659
RPL28 ribosomal protein L28 -0.0204629
RND3 Rho family GTPase 3 -0.0203903
RPL38 ribosomal protein L38 -0.020372
TCEAL9 transcription elongation factor A like 9 -0.0203371
RPL8 ribosomal protein L8 -0.0202931
RPS2 ribosomal protein S2 -0.0202849
RPS29 ribosomal protein S29 -0.0198473
HMGA1 high mobility group AT-hook 1 -0.0195603
NACA nascent polypeptide-associated complex alpha subunit -0.019526
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0193132
TMSB4X thymosin beta 4, X-linked -0.0191317
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0190047
UBE2B ubiquitin-conjugating enzyme E2B -0.0190012
RPS27 ribosomal protein S27 -0.0189799
RPL10A ribosomal protein L10a -0.0187867
SLC38A1 solute carrier family 38, member 1 -0.0186015
RPL35 ribosomal protein L35 -0.0185918
CD63 CD63 molecule -0.0185733