Baicalin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.110012
FNDC3B fibronectin type III domain containing 3B 0.0761591
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0718427
HOOK2 hook microtubule-tethering protein 2 0.0704895
TGFBI transforming growth factor, beta-induced, 68kDa 0.065266
NDRG1 N-myc downstream regulated 1 0.0643208
NAMPT nicotinamide phosphoribosyltransferase 0.0622662
VEGFA vascular endothelial growth factor A 0.0580163
ZSWIM6 zinc finger, SWIM-type containing 6 0.0577593
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0517926
GLS2 glutaminase 2 (liver, mitochondrial) 0.0514422
TRA2A transformer 2 alpha homolog (Drosophila) 0.0485055
ZNF292 zinc finger protein 292 0.0467072
TIMP3 TIMP metallopeptidase inhibitor 3 0.046504
KYNU kynureninase 0.0459385
ANKHD1 ankyrin repeat and KH domain containing 1 0.0456855
SEC31A SEC31 homolog A (S. cerevisiae) 0.0456493
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0448261
NRXN3 neurexin 3 0.0443897
KMT2E lysine (K)-specific methyltransferase 2E 0.0420077
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0412654
ELL2 elongation factor, RNA polymerase II, 2 0.040909
FLNA filamin A, alpha 0.040724
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0398226
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0393026
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0387977
COL6A1 collagen, type VI, alpha 1 0.038381
FAM13A family with sequence similarity 13, member A 0.0380834
ERRFI1 ERBB receptor feedback inhibitor 1 0.0380095
GLG1 golgi glycoprotein 1 0.0374326
CAMTA1 calmodulin binding transcription activator 1 0.0373452
RYBP RING1 and YY1 binding protein 0.0370385
SEC24A SEC24 family member A 0.0366702
STC2 stanniocalcin 2 0.0365819
CANX calnexin 0.0365439
COPA coatomer protein complex, subunit alpha 0.0360609
MYLK myosin light chain kinase 0.0354626
UGCG UDP-glucose ceramide glucosyltransferase 0.0343321
WASF2 WAS protein family, member 2 0.0331052
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0329748
COG5 component of oligomeric golgi complex 5 0.0326844
RNF145 ring finger protein 145 0.032384
OSBPL8 oxysterol binding protein-like 8 0.031907
CCDC88A coiled-coil domain containing 88A 0.031809
UBE2H ubiquitin-conjugating enzyme E2H 0.0318051
MAP1B microtubule-associated protein 1B 0.0317975
CYLD cylindromatosis (turban tumor syndrome) 0.0308605
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0307958
COL7A1 collagen, type VII, alpha 1 0.0307387
UBA6 ubiquitin-like modifier activating enzyme 6 0.0306587
LIMS1 LIM and senescent cell antigen-like domains 1 0.0303819
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0299978
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0299929
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0299432
TPM3 tropomyosin 3 0.0296433
ALK anaplastic lymphoma receptor tyrosine kinase 0.0296261
SKIC3 SKI3 subunit of superkiller complex 0.0296094
HILPDA hypoxia inducible lipid droplet-associated 0.0295361
PCBP2 poly(rC) binding protein 2 0.0292372
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0291836
XPO1 exportin 1 0.0290932
HIP1 huntingtin interacting protein 1 0.0290846
AKAP9 A kinase (PRKA) anchor protein 9 0.0290744
CCDC14 coiled-coil domain containing 14 0.0289522
CUL3 cullin 3 0.028722
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0286763
TPST1 tyrosylprotein sulfotransferase 1 0.0286411
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0286291
COG6 component of oligomeric golgi complex 6 0.028624
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0285491
ZNF395 zinc finger protein 395 0.0283814
COL5A1 collagen, type V, alpha 1 0.0282457
MCTP1 multiple C2 domains, transmembrane 1 0.0281795
AKAP13 A kinase (PRKA) anchor protein 13 0.0280573
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0277503
ATXN1 ataxin 1 0.0274102
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0272241
NFE2L1 nuclear factor, erythroid 2-like 1 0.0271523
APP amyloid beta (A4) precursor protein 0.027006
FUS FUS RNA binding protein 0.0268919
SEC24D SEC24 family member D 0.0268716
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266264
ANXA5 annexin A5 0.0262554
SOCS5 suppressor of cytokine signaling 5 0.0262044
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0261806
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0261114
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0258996
NOCT nocturnin 0.0257943
RND3 Rho family GTPase 3 0.0256641
CD109 CD109 molecule 0.0256462
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0251291
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0248731
SNX13 sorting nexin 13 0.0248531
SND1 staphylococcal nuclease and tudor domain containing 1 0.0248448
INTS6 integrator complex subunit 6 0.0246814
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0245463
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0244793
MARCHF6 membrane associated ring-CH-type finger 6 0.024389
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0242963
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0242815

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168215
MT2A metallothionein 2A -0.129882
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.123092
HLA-B major histocompatibility complex, class I, B -0.11108
COL1A1 collagen, type I, alpha 1 -0.0880899
COL1A2 collagen, type I, alpha 2 -0.0857163
CDK6 cyclin-dependent kinase 6 -0.0777305
PTMA prothymosin, alpha -0.0736238
STC1 stanniocalcin 1 -0.073073
TPT1 tumor protein, translationally-controlled 1 -0.0685056
CALU calumenin -0.0654956
FTL ferritin, light polypeptide -0.0638268
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0596894
RPLP1 ribosomal protein, large, P1 -0.0525191
MT1X metallothionein 1X -0.0520577
RPS8 ribosomal protein S8 -0.0505848
ZFAND3 zinc finger, AN1-type domain 3 -0.0498775
S100A9 S100 calcium binding protein A9 -0.046796
LOX lysyl oxidase -0.0461553
RPS6 ribosomal protein S6 -0.0451959
H3-3B H3.3 histone B -0.0449348
RPS24 ribosomal protein S24 -0.0446346
S100A6 S100 calcium binding protein A6 -0.0445893
GLIS3 GLIS family zinc finger 3 -0.0434546
RPLP2 ribosomal protein, large, P2 -0.0433076
TM4SF1 transmembrane 4 L six family member 1 -0.0415765
TRIO trio Rho guanine nucleotide exchange factor -0.0414606
EIF1 eukaryotic translation initiation factor 1 -0.0410293
ACTG1 actin gamma 1 -0.0408422
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0400866
EGR1 early growth response 1 -0.0392851
RPL35A ribosomal protein L35a -0.0390201
CAVIN1 caveolae associated protein 1 -0.0382615
RACK1 receptor for activated C kinase 1 -0.0377048
RPS5 ribosomal protein S5 -0.0366678
COL3A1 collagen, type III, alpha 1 -0.0364721
CBX3 chromobox homolog 3 -0.0364444
ZMYND8 zinc finger, MYND-type containing 8 -0.0361358
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0357334
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0347832
RPS19 ribosomal protein S19 -0.0343841
CCNI cyclin I -0.0339529
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0339068
EIF5B eukaryotic translation initiation factor 5B -0.0329446
TXNRD1 thioredoxin reductase 1 -0.0329169
RRBP1 ribosome binding protein 1 -0.0327232
EFNA5 ephrin-A5 -0.0324164
CTSB cathepsin B -0.0323507
F3 coagulation factor III (thromboplastin, tissue factor) -0.0321122
RPL26 ribosomal protein L26 -0.0316144
DDIT4 DNA-damage-inducible transcript 4 -0.0315918
CA12 carbonic anhydrase XII -0.0313184
FMNL2 formin-like 2 -0.031202
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0303918
RPL37 ribosomal protein L37 -0.0300624
PLCB4 phospholipase C, beta 4 -0.0300054
MAP4 microtubule-associated protein 4 -0.0293811
MBD5 methyl-CpG binding domain protein 5 -0.0293337
FLOT1 flotillin 1 -0.0287862
HLA-C major histocompatibility complex, class I, C -0.0286848
CFDP1 craniofacial development protein 1 -0.0286229
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0286092
ZEB1 zinc finger E-box binding homeobox 1 -0.0284051
PCM1 pericentriolar material 1 -0.0281651
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0280569
FER fer (fps/fes related) tyrosine kinase -0.0279375
FRMD4A FERM domain containing 4A -0.0279183
LOC102724023 ES1 protein homolog, mitochondrial -0.0278339
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.0275834
PDE4D phosphodiesterase 4D, cAMP-specific -0.0274539
PTPRG protein tyrosine phosphatase, receptor type, G -0.027344
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0271702
VDAC1 voltage-dependent anion channel 1 -0.0270438
COL6A3 collagen, type VI, alpha 3 -0.026284
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0261705
EMP1 epithelial membrane protein 1 -0.0261543
PLAUR plasminogen activator, urokinase receptor -0.026071
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0260388
NKD1 naked cuticle homolog 1 (Drosophila) -0.0259912
PRRC2C proline-rich coiled-coil 2C -0.0256009
PGK1 phosphoglycerate kinase 1 -0.0253599
CD9 CD9 molecule -0.0253243
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0251062
RAB1A RAB1A, member RAS oncogene family -0.0250864
JAK1 Janus kinase 1 -0.0247487
LSAMP limbic system-associated membrane protein -0.0247457
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0247038
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0245915
SLC38A2 solute carrier family 38, member 2 -0.024591
SERINC3 serine incorporator 3 -0.0245763
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0243159
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0242322
RPS23 ribosomal protein S23 -0.0242034
TUBB tubulin, beta class I -0.0240058
SLC38A1 solute carrier family 38, member 1 -0.0239887
PSD3 pleckstrin and Sec7 domain containing 3 -0.0239645
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0237347
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.023714
NABP1 nucleic acid binding protein 1 -0.0236026
ADNP activity-dependent neuroprotector homeobox -0.0235338