Baicalin_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Baicalin perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Baicalin_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0606327
ANKRD28 ankyrin repeat domain 28 0.0568695
SMAD3 SMAD family member 3 0.0545643
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0513128
PCBP2 poly(rC) binding protein 2 0.0484723
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0480456
ELL2 elongation factor, RNA polymerase II, 2 0.044762
CHD1 chromodomain helicase DNA binding protein 1 0.0436823
TXNRD1 thioredoxin reductase 1 0.0418709
PBX3 pre-B-cell leukemia homeobox 3 0.0413248
TPX2 TPX2, microtubule-associated 0.0393884
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0390394
EEF2 eukaryotic translation elongation factor 2 0.038697
CENPF centromere protein F, 350/400kDa 0.0376012
NAV2 neuron navigator 2 0.0371284
ZNF292 zinc finger protein 292 0.036878
YAP1 Yes-associated protein 1 0.0367017
DIAPH3 diaphanous-related formin 3 0.0364008
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0353958
KIAA1958 KIAA1958 0.0350363
BIRC3 baculoviral IAP repeat containing 3 0.0341401
KIAA1328 KIAA1328 0.0327351
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0321614
AKAP9 A kinase (PRKA) anchor protein 9 0.0308243
ECT2 epithelial cell transforming 2 0.0307054
DGKD diacylglycerol kinase, delta 130kDa 0.030681
MBNL2 muscleblind-like splicing regulator 2 0.0305068
CD44 CD44 molecule (Indian blood group) 0.0303532
ARL15 ADP-ribosylation factor-like 15 0.0302535
MYH9 myosin, heavy chain 9, non-muscle 0.0300261
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.029449
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0293453
MKI67 marker of proliferation Ki-67 0.0292837
CKAP2 cytoskeleton associated protein 2 0.0292536
SPAG9 sperm associated antigen 9 0.0286556
HJURP Holliday junction recognition protein 0.0285883
WDPCP WD repeat containing planar cell polarity effector 0.0280595
RSRC2 arginine/serine-rich coiled-coil 2 0.0279664
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0277319
RB1CC1 RB1-inducible coiled-coil 1 0.0276001
DSCAM Down syndrome cell adhesion molecule 0.0272913
CEP250 centrosomal protein 250kDa 0.0272151
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0269426
MRE11 MRE11 homolog, double strand break repair nuclease 0.0264174
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0264162
ANKRD36C ankyrin repeat domain 36C 0.0259964
XPO1 exportin 1 0.0254325
PSME4 proteasome (prosome, macropain) activator subunit 4 0.025158
MIS18BP1 MIS18 binding protein 1 0.0251524
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0251089
NCEH1 neutral cholesterol ester hydrolase 1 0.0248843
SGO2 shugoshin 2 0.0243911
ANLN anillin, actin binding protein 0.0243327
GIGYF2 GRB10 interacting GYF protein 2 0.023727
PER1 period circadian clock 1 0.0235266
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0234746
RFC3 replication factor C (activator 1) 3, 38kDa 0.0233668
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0232669
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0231365
MATR3 matrin 3 0.0229445
TRA2A transformer 2 alpha homolog (Drosophila) 0.0226633
RNF145 ring finger protein 145 0.0225116
PCNX1 pecanex 1 0.0224889
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0224469
TFG TRK-fused gene 0.022191
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0220881
GLS2 glutaminase 2 (liver, mitochondrial) 0.0219773
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0219566
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0219279
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0218177
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0217527
AFF4 AF4/FMR2 family, member 4 0.0217512
NCAPD2 non-SMC condensin I complex, subunit D2 0.0217443
YBX3 Y box binding protein 3 0.0216514
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0214923
PCM1 pericentriolar material 1 0.02141
STK24 serine/threonine kinase 24 0.0212526
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0212315
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0209579
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0207944
CEP295 centrosomal protein 295kDa 0.0205547
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0205015
NUMA1 nuclear mitotic apparatus protein 1 0.0204838
CKAP2L cytoskeleton associated protein 2-like 0.0203606
CUL3 cullin 3 0.0203312
SSH1 slingshot protein phosphatase 1 0.0203033
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0202828
CORO1C coronin, actin binding protein, 1C 0.0202711
CENPE centromere protein E, 312kDa 0.0200922
KIF23 kinesin family member 23 0.0197185
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0195976
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.019204
PANK3 pantothenate kinase 3 0.0191718
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0190905
TTK TTK protein kinase 0.0190831
ATAD2B ATPase family, AAA domain containing 2B 0.0190274
PNN pinin, desmosome associated protein 0.0189045
WWTR1 WW domain containing transcription regulator 1 0.0188897
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0188029
AMBRA1 autophagy/beclin-1 regulator 1 0.018701

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.304488
TPT1 tumor protein, translationally-controlled 1 -0.163793
VIM vimentin -0.120208
LDHA lactate dehydrogenase A -0.0998064
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0985699
TMSB10 thymosin beta 10 -0.0981402
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.075632
HMGA2 high mobility group AT-hook 2 -0.0735277
FNDC3B fibronectin type III domain containing 3B -0.0691632
ANGPTL4 angiopoietin-like 4 -0.059995
NDRG1 N-myc downstream regulated 1 -0.0583122
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0568066
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0525626
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0524991
PRR16 proline rich 16 -0.0511713
PTMA prothymosin, alpha -0.051104
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0510329
TM4SF1 transmembrane 4 L six family member 1 -0.0508504
ZBTB20 zinc finger and BTB domain containing 20 -0.0506325
AHNAK AHNAK nucleoprotein -0.0498866
POTEF POTE ankyrin domain family, member F -0.0495266
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0487741
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0474665
RAI14 retinoic acid induced 14 -0.0466961
DST dystonin -0.044602
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0432791
IGF2 insulin-like growth factor 2 -0.0431409
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0415245
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0415048
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0397839
MT2A metallothionein 2A -0.0392912
TPI1 triosephosphate isomerase 1 -0.039113
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0386543
PLEK2 pleckstrin 2 -0.0379965
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0379211
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0372921
ACTG1 actin gamma 1 -0.0369505
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0364209
PRSS23 protease, serine, 23 -0.0364097
EIF1 eukaryotic translation initiation factor 1 -0.0360897
ENO1 enolase 1, (alpha) -0.0360473
PODXL podocalyxin-like -0.0359301
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0356173
BTG1 B-cell translocation gene 1, anti-proliferative -0.0351088
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0349734
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0348103
PCED1B PC-esterase domain containing 1B -0.0346359
IGFBP3 insulin-like growth factor binding protein 3 -0.0346214
FMN1 formin 1 -0.0345365
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0344823
RPL35A ribosomal protein L35a -0.0335342
B2M beta-2-microglobulin -0.0331971
S100A6 S100 calcium binding protein A6 -0.032712
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0325539
PTPRG protein tyrosine phosphatase, receptor type, G -0.0318284
RPLP1 ribosomal protein, large, P1 -0.0316293
SLC38A2 solute carrier family 38, member 2 -0.0314857
FTH1 ferritin, heavy polypeptide 1 -0.0314601
DNAAF9 dynein axonemal assembly factor 9 -0.0308132
S100A10 S100 calcium binding protein A10 -0.0304605
RPL26 ribosomal protein L26 -0.0304217
HILPDA hypoxia inducible lipid droplet-associated -0.0302613
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0301887
MYOF myoferlin -0.0299357
ARHGAP5 Rho GTPase activating protein 5 -0.0290604
LOC112694756 uncharaterized LOC112694756 -0.0287844
EGFR epidermal growth factor receptor -0.0284027
MACF1 microtubule-actin crosslinking factor 1 -0.0283705
DYNLRB1 dynein, light chain, roadblock-type 1 -0.028178
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0279852
CAVIN1 caveolae associated protein 1 -0.0275335
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0275293
NPAS2 neuronal PAS domain protein 2 -0.0273038
WSB1 WD repeat and SOCS box containing 1 -0.026898
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0268715
INTS6 integrator complex subunit 6 -0.02687
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0268505
IER3 immediate early response 3 -0.0265605
ZFHX3 zinc finger homeobox 3 -0.0265433
EGR1 early growth response 1 -0.0263347
PURA purine-rich element binding protein A -0.0263217
UBB ubiquitin B -0.0259812
HLA-B major histocompatibility complex, class I, B -0.0259518
PARD3 par-3 family cell polarity regulator -0.0258617
ASPH aspartate beta-hydroxylase -0.0255431
NALCN sodium leak channel, non selective -0.0253442
RPL9 ribosomal protein L9 -0.0251563
FTL ferritin, light polypeptide -0.0250774
RPS13 ribosomal protein S13 -0.0250758
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.025009
GPC6 glypican 6 -0.0249375
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0249054
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0247728
PTK2 protein tyrosine kinase 2 -0.0247088
RPS6 ribosomal protein S6 -0.0247078
COL5A1 collagen, type V, alpha 1 -0.024582
RPS21 ribosomal protein S21 -0.0245719
THBS1 thrombospondin 1 -0.0241183
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0240166
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0236446